Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Outer membrane protein A

Gene

ompA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • porin activity Source: EcoCyc
  • structural molecule activity Source: InterPro

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • conjugation Source: EcoliWiki
  • detection of virus Source: EcoliWiki
  • ion transmembrane transport Source: EcoCyc
  • ion transport Source: EcoliWiki
  • viral entry into host cell Source: EcoliWiki

Keywordsi

Molecular functionPorin
Biological processConjugation, Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10669-MONOMER

Protein family/group databases

TCDBi1.B.6.1.1 the ompa-ompf porin (oop) family

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II*
Gene namesi
Name:ompA
Synonyms:con, tolG, tut
Ordered Locus Names:b0957, JW0940
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10669 ompA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 26Periplasmic5
Transmembranei27 – 37Beta strandedAdd BLAST11
Topological domaini38 – 54ExtracellularAdd BLAST17
Transmembranei55 – 66Beta strandedAdd BLAST12
Topological domaini67 – 69Periplasmic3
Transmembranei70 – 78Beta stranded9
Topological domaini79 – 95ExtracellularAdd BLAST17
Transmembranei96 – 107Beta strandedAdd BLAST12
Topological domaini108 – 111Periplasmic4
Transmembranei112 – 124Beta strandedAdd BLAST13
Topological domaini125 – 137ExtracellularAdd BLAST13
Transmembranei138 – 151Beta strandedAdd BLAST14
Topological domaini152 – 155Periplasmic4
Transmembranei156 – 163Beta stranded8
Topological domaini164 – 181ExtracellularAdd BLAST18
Transmembranei182 – 190Beta stranded9
Topological domaini191 – 346PeriplasmicAdd BLAST156

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 214 PublicationsAdd BLAST21
ChainiPRO_000002009422 – 346Outer membrane protein AAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi311 ↔ 323

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP0A910
PaxDbiP0A910
PRIDEiP0A910

2D gel databases

SWISS-2DPAGEiP0A910

PTM databases

CarbonylDBiP0A910

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4260032, 1011 interactors
849945, 1 interactor
DIPiDIP-31879N
IntActiP0A910, 18 interactors
MINTiP0A910
STRINGi316385.ECDH10B_1027

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A910
SMRiP0A910
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A910

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati201 – 20212
Repeati203 – 20422
Repeati205 – 20632
Repeati207 – 20842
Domaini210 – 338OmpA-likePROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 208Hinge-likeAdd BLAST12
Regioni201 – 2084 X 2 AA tandem repeats of A-P8

Sequence similaritiesi

Belongs to the OmpA family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105UYK Bacteria
COG2885 LUCA
HOGENOMiHOG000274199
InParanoidiP0A910
KOiK03286
OMAiHDTGFYG

Family and domain databases

CDDicd07185 OmpA_C-like, 1 hit
Gene3Di3.30.1330.60, 1 hit
InterProiView protein in InterPro
IPR011250 OMP/PagP_b-brl
IPR006664 OMP_bac
IPR002368 OmpA
IPR006665 OmpA-like
IPR006690 OMPA-like_CS
IPR036737 OmpA-like_sf
IPR000498 OmpA-like_TM_dom
PfamiView protein in Pfam
PF00691 OmpA, 1 hit
PF01389 OmpA_membrane, 1 hit
PRINTSiPR01021 OMPADOMAIN
PR01022 OUTRMMBRANEA
SUPFAMiSSF103088 SSF103088, 1 hit
SSF56925 SSF56925, 1 hit
PROSITEiView protein in PROSITE
PS01068 OMPA_1, 1 hit
PS51123 OMPA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKTAIAIAV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFINNNGP
60 70 80 90 100
THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL
110 120 130 140 150
TAKLGYPITD DLDIYTRLGG MVWRADTKSN VYGKNHDTGV SPVFAGGVEY
160 170 180 190 200
AITPEIATRL EYQWTNNIGD AHTIGTRPDN GMLSLGVSYR FGQGEAAPVV
210 220 230 240 250
APAPAPAPEV QTKHFTLKSD VLFNFNKATL KPEGQAALDQ LYSQLSNLDP
260 270 280 290 300
KDGSVVVLGY TDRIGSDAYN QGLSERRAQS VVDYLISKGI PADKISARGM
310 320 330 340
GESNPVTGNT CDNVKQRAAL IDCLAPDRRV EIEVKGIKDV VTQPQA
Length:346
Mass (Da):37,201
Last modified:July 21, 1986 - v1
Checksum:i195147734CDF8B04
GO

Mass spectrometryi

Molecular mass is 35177 Da from positions 22 - 346. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00307 Genomic DNA Translation: CAA23588.1
U00096 Genomic DNA Translation: AAC74043.1
AP009048 Genomic DNA Translation: BAA35715.1
PIRiA93707 MMECA
RefSeqiNP_415477.1, NC_000913.3
WP_000750416.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74043; AAC74043; b0957
BAA35715; BAA35715; BAA35715
GeneIDi945571
KEGGiecj:JW0940
eco:b0957
PATRICifig|1411691.4.peg.1317

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00307 Genomic DNA Translation: CAA23588.1
U00096 Genomic DNA Translation: AAC74043.1
AP009048 Genomic DNA Translation: BAA35715.1
PIRiA93707 MMECA
RefSeqiNP_415477.1, NC_000913.3
WP_000750416.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXWX-ray2.50A21-192[»]
1G90NMR-A22-197[»]
1QJPX-ray1.65A22-192[»]
2GE4NMR-A22-197[»]
2JMMNMR-A23-197[»]
3JBUelectron microscopy3.64z1-24[»]
3NB3electron microscopy-A/B/C1-346[»]
5M2QX-ray1.70A/B1-22[»]
ProteinModelPortaliP0A910
SMRiP0A910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260032, 1011 interactors
849945, 1 interactor
DIPiDIP-31879N
IntActiP0A910, 18 interactors
MINTiP0A910
STRINGi316385.ECDH10B_1027

Chemistry databases

DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane

Protein family/group databases

TCDBi1.B.6.1.1 the ompa-ompf porin (oop) family

PTM databases

CarbonylDBiP0A910

2D gel databases

SWISS-2DPAGEiP0A910

Proteomic databases

EPDiP0A910
PaxDbiP0A910
PRIDEiP0A910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74043; AAC74043; b0957
BAA35715; BAA35715; BAA35715
GeneIDi945571
KEGGiecj:JW0940
eco:b0957
PATRICifig|1411691.4.peg.1317

Organism-specific databases

EchoBASEiEB0663
EcoGeneiEG10669 ompA

Phylogenomic databases

eggNOGiENOG4105UYK Bacteria
COG2885 LUCA
HOGENOMiHOG000274199
InParanoidiP0A910
KOiK03286
OMAiHDTGFYG

Enzyme and pathway databases

BioCyciEcoCyc:EG10669-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A910
PROiPR:P0A910

Family and domain databases

CDDicd07185 OmpA_C-like, 1 hit
Gene3Di3.30.1330.60, 1 hit
InterProiView protein in InterPro
IPR011250 OMP/PagP_b-brl
IPR006664 OMP_bac
IPR002368 OmpA
IPR006665 OmpA-like
IPR006690 OMPA-like_CS
IPR036737 OmpA-like_sf
IPR000498 OmpA-like_TM_dom
PfamiView protein in Pfam
PF00691 OmpA, 1 hit
PF01389 OmpA_membrane, 1 hit
PRINTSiPR01021 OMPADOMAIN
PR01022 OUTRMMBRANEA
SUPFAMiSSF103088 SSF103088, 1 hit
SSF56925 SSF56925, 1 hit
PROSITEiView protein in PROSITE
PS01068 OMPA_1, 1 hit
PS51123 OMPA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOMPA_ECOLI
AccessioniPrimary (citable) accession number: P0A910
Secondary accession number(s): P02934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again