UniProtKB - P0A901 (BLC_ECOLI)
Protein
Outer membrane lipoprotein Blc
Gene
blc
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.1 Publication
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- lipid metabolic process Source: GO_Central
- response to reactive oxygen species Source: GO_Central
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7837-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Outer membrane lipoprotein Blc |
Gene namesi | Name:blc Synonyms:yjeL Ordered Locus Names:b4149, JW4110 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cell outer membrane Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cell outer membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | CuratedAdd BLAST | 18 | |
ChainiPRO_0000017991 | 19 – 177 | Outer membrane lipoprotein BlcAdd BLAST | 159 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 19 | N-palmitoyl cysteineCurated | 1 | |
Lipidationi | 19 | S-diacylglycerol cysteineCurated | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
jPOSTi | P0A901 |
PaxDbi | P0A901 |
PRIDEi | P0A901 |
Expressioni
Inductioni
By starvation and high osmolarity.
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4261278, 195 interactors |
DIPi | DIP-35862N |
IntActi | P0A901, 6 interactors |
STRINGi | 511145.b4149 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A901 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A901 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG3040, Bacteria |
HOGENOMi | CLU_068449_3_0_6 |
InParanoidi | P0A901 |
PhylomeDBi | P0A901 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR002446, Lipocalin_bac IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
Pfami | View protein in Pfam PF08212, Lipocalin_2, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit |
PRINTSi | PR01171, BCTLIPOCALIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLPLVAAA TAAFLVVACS SPTPPRGVTV VNNFDAKRYL GTWYEIARFD
60 70 80 90 100
HRFERGLEKV TATYSLRDDG GLNVINKGYN PDRGMWQQSE GKAYFTGAPT
110 120 130 140 150
RAALKVSFFG PFYGGYNVIA LDREYRHALV CGPDRDYLWI LSRTPTISDE
160 170
VKQEMLAVAT REGFDVSKFI WVQQPGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21726 Genomic DNA Translation: AAC46452.1 U14003 Genomic DNA Translation: AAA97048.1 U00096 Genomic DNA Translation: AAC77109.1 AP009048 Genomic DNA Translation: BAE78153.1 |
PIRi | I84534 |
RefSeqi | NP_418573.1, NC_000913.3 WP_001238378.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77109; AAC77109; b4149 BAE78153; BAE78153; BAE78153 |
GeneIDi | 57730045 948670 |
KEGGi | ecj:JW4110 eco:b4149 |
PATRICi | fig|1411691.4.peg.2549 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21726 Genomic DNA Translation: AAC46452.1 U14003 Genomic DNA Translation: AAA97048.1 U00096 Genomic DNA Translation: AAC77109.1 AP009048 Genomic DNA Translation: BAE78153.1 |
PIRi | I84534 |
RefSeqi | NP_418573.1, NC_000913.3 WP_001238378.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QWD | X-ray | 1.75 | A/B | 23-177 | [»] | |
2ACO | X-ray | 1.80 | A/B | 23-177 | [»] | |
3MBT | X-ray | 2.60 | A | 19-177 | [»] | |
6UKK | X-ray | 1.60 | A | 23-177 | [»] | |
SMRi | P0A901 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261278, 195 interactors |
DIPi | DIP-35862N |
IntActi | P0A901, 6 interactors |
STRINGi | 511145.b4149 |
Proteomic databases
jPOSTi | P0A901 |
PaxDbi | P0A901 |
PRIDEi | P0A901 |
Genome annotation databases
EnsemblBacteriai | AAC77109; AAC77109; b4149 BAE78153; BAE78153; BAE78153 |
GeneIDi | 57730045 948670 |
KEGGi | ecj:JW4110 eco:b4149 |
PATRICi | fig|1411691.4.peg.2549 |
Organism-specific databases
EchoBASEi | EB2367 |
Phylogenomic databases
eggNOGi | COG3040, Bacteria |
HOGENOMi | CLU_068449_3_0_6 |
InParanoidi | P0A901 |
PhylomeDBi | P0A901 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7837-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A901 |
PROi | PR:P0A901 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR002446, Lipocalin_bac IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
Pfami | View protein in Pfam PF08212, Lipocalin_2, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit |
PRINTSi | PR01171, BCTLIPOCALIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BLC_ECOLI | |
Accessioni | P0A901Primary (citable) accession number: P0A901 Secondary accession number(s): P39281, Q2M6F3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 10, 2021 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families