UniProtKB - P0A8Z0 (YCIA_ECOLI)
Protein
Acyl-CoA thioester hydrolase YciA
Gene
yciA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.1 Publication
GO - Molecular functioni
- acyl-CoA hydrolase activity Source: EcoCyc
- long-chain fatty acyl-CoA binding Source: GO_Central
GO - Biological processi
- acyl-CoA metabolic process Source: GO_Central
- fatty acid metabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11121-MONOMER MetaCyc:EG11121-MONOMER |
BRENDAi | 3.1.2.2, 2026 3.1.2.20, 2026 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:yciA Ordered Locus Names:b1253, JW1245 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053817 | 1 – 132 | Acyl-CoA thioester hydrolase YciAAdd BLAST | 132 |
Proteomic databases
jPOSTi | P0A8Z0 |
PaxDbi | P0A8Z0 |
PRIDEi | P0A8Z0 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262997, 21 interactors |
DIPi | DIP-35956N |
IntActi | P0A8Z0, 14 interactors |
STRINGi | 511145.b1253 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 123 | HotDog ACOT-typePROSITE-ProRule annotationAdd BLAST | 116 |
Sequence similaritiesi
Belongs to the acyl coenzyme A hydrolase family.Curated
Phylogenomic databases
eggNOGi | COG1607, Bacteria |
HOGENOMi | CLU_050164_2_0_6 |
InParanoidi | P0A8Z0 |
PhylomeDBi | P0A8Z0 |
Family and domain databases
InterProi | View protein in InterPro IPR040170, Cytosol_ACT IPR033120, HOTDOG_ACOT IPR029069, HotDog_dom_sf IPR006683, Thioestr_dom |
PANTHERi | PTHR11049, PTHR11049, 1 hit |
Pfami | View protein in Pfam PF03061, 4HBT, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit |
PROSITEi | View protein in PROSITE PS51770, HOTDOG_ACOT, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A8Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTHNVPQG DLVLRTLAMP ADTNANGDIF GGWLMSQMDI GGAILAKEIA
60 70 80 90 100
HGRVVTVRVE GMTFLRPVAV GDVVCCYARC VQKGTTSVSI NIEVWVKKVA
110 120 130
SEPIGQRYKA TEALFKYVAV DPEGKPRALP VE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K00431 Genomic DNA Translation: AAB59067.1 U24195 Genomic DNA Translation: AAB60068.1 U24196 Genomic DNA Translation: AAB60076.1 U24197 Genomic DNA Translation: AAB60084.1 U24198 Genomic DNA Translation: AAB60092.1 U24199 Genomic DNA Translation: AAB60100.1 U24200 Genomic DNA Translation: AAB60108.1 U24201 Genomic DNA Translation: AAB60116.1 U24202 Genomic DNA Translation: AAB60124.1 U24203 Genomic DNA Translation: AAB60132.1 U24204 Genomic DNA Translation: AAB60140.1 U24205 Genomic DNA Translation: AAB60148.1 U24206 Genomic DNA Translation: AAB60156.1 U00096 Genomic DNA Translation: AAC74335.1 AP009048 Genomic DNA Translation: BAA14785.1 |
PIRi | A05224 |
RefSeqi | NP_415769.1, NC_000913.3 WP_000108160.1, NZ_STEB01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAC74335; AAC74335; b1253 BAA14785; BAA14785; BAA14785 |
GeneIDi | 58388669 946634 |
KEGGi | ecj:JW1245 eco:b1253 |
PATRICi | fig|1411691.4.peg.1030 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K00431 Genomic DNA Translation: AAB59067.1 U24195 Genomic DNA Translation: AAB60068.1 U24196 Genomic DNA Translation: AAB60076.1 U24197 Genomic DNA Translation: AAB60084.1 U24198 Genomic DNA Translation: AAB60092.1 U24199 Genomic DNA Translation: AAB60100.1 U24200 Genomic DNA Translation: AAB60108.1 U24201 Genomic DNA Translation: AAB60116.1 U24202 Genomic DNA Translation: AAB60124.1 U24203 Genomic DNA Translation: AAB60132.1 U24204 Genomic DNA Translation: AAB60140.1 U24205 Genomic DNA Translation: AAB60148.1 U24206 Genomic DNA Translation: AAB60156.1 U00096 Genomic DNA Translation: AAC74335.1 AP009048 Genomic DNA Translation: BAA14785.1 |
PIRi | A05224 |
RefSeqi | NP_415769.1, NC_000913.3 WP_000108160.1, NZ_STEB01000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G6S | model | - | A | 1-132 | [»] | |
SMRi | P0A8Z0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262997, 21 interactors |
DIPi | DIP-35956N |
IntActi | P0A8Z0, 14 interactors |
STRINGi | 511145.b1253 |
Proteomic databases
jPOSTi | P0A8Z0 |
PaxDbi | P0A8Z0 |
PRIDEi | P0A8Z0 |
Genome annotation databases
EnsemblBacteriai | AAC74335; AAC74335; b1253 BAA14785; BAA14785; BAA14785 |
GeneIDi | 58388669 946634 |
KEGGi | ecj:JW1245 eco:b1253 |
PATRICi | fig|1411691.4.peg.1030 |
Organism-specific databases
EchoBASEi | EB1111 |
Phylogenomic databases
eggNOGi | COG1607, Bacteria |
HOGENOMi | CLU_050164_2_0_6 |
InParanoidi | P0A8Z0 |
PhylomeDBi | P0A8Z0 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11121-MONOMER MetaCyc:EG11121-MONOMER |
BRENDAi | 3.1.2.2, 2026 3.1.2.20, 2026 |
Miscellaneous databases
PROi | PR:P0A8Z0 |
Family and domain databases
InterProi | View protein in InterPro IPR040170, Cytosol_ACT IPR033120, HOTDOG_ACOT IPR029069, HotDog_dom_sf IPR006683, Thioestr_dom |
PANTHERi | PTHR11049, PTHR11049, 1 hit |
Pfami | View protein in Pfam PF03061, 4HBT, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit |
PROSITEi | View protein in PROSITE PS51770, HOTDOG_ACOT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YCIA_ECOLI | |
Accessioni | P0A8Z0Primary (citable) accession number: P0A8Z0 Secondary accession number(s): P04379 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | March 20, 1987 | |
Last modified: | April 7, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families