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UniProtKB - P0A8Z0 (YCIA_ECOLI)

Entry version 113 (07 Apr 2021)
Sequence version 1 (20 Mar 1987)
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Protein

Acyl-CoA thioester hydrolase YciA

Gene

yciA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG11121-MONOMER
MetaCyc:EG11121-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.2.2, 2026
3.1.2.20, 2026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-CoA thioester hydrolase YciA (EC:3.1.2.-)
Alternative name(s):
Protein P14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yciA
Ordered Locus Names:b1253, JW1245
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538171 – 132Acyl-CoA thioester hydrolase YciAAdd BLAST132

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0A8Z0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0A8Z0

PRoteomics IDEntifications database

More...PRIDEi		P0A8Z0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262997, 21 interactors

Database of interacting proteins

More...DIPi		DIP-35956N

Protein interaction database and analysis system

More...IntActi		P0A8Z0, 14 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1253

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0A8Z0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 123HotDog ACOT-typePROSITE-ProRule annotationAdd BLAST116

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1607, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_050164_2_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0A8Z0

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0A8Z0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040170, Cytosol_ACT
IPR033120, HOTDOG_ACOT
IPR029069, HotDog_dom_sf
IPR006683, Thioestr_dom

The PANTHER Classification System

More...PANTHERi		PTHR11049, PTHR11049, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03061, 4HBT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54637, SSF54637, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51770, HOTDOG_ACOT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A8Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTHNVPQG DLVLRTLAMP ADTNANGDIF GGWLMSQMDI GGAILAKEIA 
        60         70         80         90        100
HGRVVTVRVE GMTFLRPVAV GDVVCCYARC VQKGTTSVSI NIEVWVKKVA 
       110        120        130 
SEPIGQRYKA TEALFKYVAV DPEGKPRALP VE
Length:132
Mass (Da):14,231
Last modified:March 20, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF29C49DBB6B50DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
K00431 Genomic DNA Translation: AAB59067.1
U24195 Genomic DNA Translation: AAB60068.1
U24196 Genomic DNA Translation: AAB60076.1
U24197 Genomic DNA Translation: AAB60084.1
U24198 Genomic DNA Translation: AAB60092.1
U24199 Genomic DNA Translation: AAB60100.1
U24200 Genomic DNA Translation: AAB60108.1
U24201 Genomic DNA Translation: AAB60116.1
U24202 Genomic DNA Translation: AAB60124.1
U24203 Genomic DNA Translation: AAB60132.1
U24204 Genomic DNA Translation: AAB60140.1
U24205 Genomic DNA Translation: AAB60148.1
U24206 Genomic DNA Translation: AAB60156.1
U00096 Genomic DNA Translation: AAC74335.1
AP009048 Genomic DNA Translation: BAA14785.1

Protein sequence database of the Protein Information Resource

More...PIRi		A05224

NCBI Reference Sequences

More...RefSeqi		NP_415769.1, NC_000913.3
WP_000108160.1, NZ_STEB01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74335; AAC74335; b1253
BAA14785; BAA14785; BAA14785

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58388669
946634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1245
eco:b1253

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1030

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00431 Genomic DNA Translation: AAB59067.1
U24195 Genomic DNA Translation: AAB60068.1
U24196 Genomic DNA Translation: AAB60076.1
U24197 Genomic DNA Translation: AAB60084.1
U24198 Genomic DNA Translation: AAB60092.1
U24199 Genomic DNA Translation: AAB60100.1
U24200 Genomic DNA Translation: AAB60108.1
U24201 Genomic DNA Translation: AAB60116.1
U24202 Genomic DNA Translation: AAB60124.1
U24203 Genomic DNA Translation: AAB60132.1
U24204 Genomic DNA Translation: AAB60140.1
U24205 Genomic DNA Translation: AAB60148.1
U24206 Genomic DNA Translation: AAB60156.1
U00096 Genomic DNA Translation: AAC74335.1
AP009048 Genomic DNA Translation: BAA14785.1
PIRiA05224
RefSeqiNP_415769.1, NC_000913.3
WP_000108160.1, NZ_STEB01000005.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6Smodel-A1-132[»]
SMRiP0A8Z0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4262997, 21 interactors
DIPiDIP-35956N
IntActiP0A8Z0, 14 interactors
STRINGi511145.b1253

Proteomic databases

jPOSTiP0A8Z0
PaxDbiP0A8Z0
PRIDEiP0A8Z0

Genome annotation databases

EnsemblBacteriaiAAC74335; AAC74335; b1253
BAA14785; BAA14785; BAA14785
GeneIDi58388669
946634
KEGGiecj:JW1245
eco:b1253
PATRICifig|1411691.4.peg.1030

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1111

Phylogenomic databases

eggNOGiCOG1607, Bacteria
HOGENOMiCLU_050164_2_0_6
InParanoidiP0A8Z0
PhylomeDBiP0A8Z0

Enzyme and pathway databases

BioCyciEcoCyc:EG11121-MONOMER
MetaCyc:EG11121-MONOMER
BRENDAi3.1.2.2, 2026
3.1.2.20, 2026

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0A8Z0

Family and domain databases

InterProiView protein in InterPro
IPR040170, Cytosol_ACT
IPR033120, HOTDOG_ACOT
IPR029069, HotDog_dom_sf
IPR006683, Thioestr_dom
PANTHERiPTHR11049, PTHR11049, 1 hit
PfamiView protein in Pfam
PF03061, 4HBT, 1 hit
SUPFAMiSSF54637, SSF54637, 1 hit
PROSITEiView protein in PROSITE
PS51770, HOTDOG_ACOT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYCIA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A8Z0
Secondary accession number(s): P04379
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: April 7, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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