UniProtKB - P0A8T7 (RPOC_ECOLI)
DNA-directed RNA polymerase subunit beta'
rpoC
Functioni
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
UniRule annotation2 PublicationsResistance to the antibiotics salinamide A, salinamide B, rifampicin, streptolydigin, CBR703, myxopyronin, and lipiarmycin can result from mutations in this protein.
1 Publication1 PublicationPart of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNAP. It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.
1 PublicationCatalytic activityi
- EC:2.7.7.6UniRule annotation
Cofactori
Protein has several cofactor binding sites:- Mg2+Combined sources2 PublicationsNote: Binds 1 Mg2+ ion per subunit.Combined sources2 Publications
- Zn2+Combined sources2 PublicationsNote: Binds 2 Zn2+ ions per subunit.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 70 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 72 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 85 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 88 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 460 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 462 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 464 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 814 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 888 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 895 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 898 | Zinc 2Combined sources1 Publication | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- regulation of DNA-templated transcription, initiation Source: ComplexPortal
- response to antibiotic Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-UniRule
- transcription antitermination Source: ComplexPortal
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Antibiotic resistance, Transcription |
Ligand | Magnesium, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:RPOC-MONOMER |
BRENDAi | 2.7.7.6, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)Short name: RNAP subunit beta'UniRule annotation Alternative name(s): RNA polymerase subunit beta'UniRule annotation Transcriptase subunit beta'UniRule annotation |
Gene namesi | Name:rpoCUniRule annotation Synonyms:tabB Ordered Locus Names:b3988, JW3951 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: EcoCyc
- cytosolic DNA-directed RNA polymerase complex Source: ComplexPortal
Other locations
Keywords - Cellular componenti
DNA-directed RNA polymerasePathology & Biotechi
Biotechnological usei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 504 | Q → P: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 690 | N → D: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 697 | M → V: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 735 | A → T: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 738 | R → C, H, P or S: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 748 | A → E: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 758 | P → S or T: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 763 | F → C: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 775 | S → A: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 779 | A → T or V: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 780 | R → C: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 782 | G → A or C: Resistant to antibiotics salinamide A and B. 1 Publication | 1 | |
Mutagenesisi | 783 | L → R: Resistant to antibiotics salinamide A and B. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL2364672 CHEMBL4296169 |
DrugBanki | DB00615, Rifabutin DB11753, Rifamycin |
DrugCentrali | P0A8T7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067741 | 1 – 1407 | DNA-directed RNA polymerase subunit beta'Add BLAST | 1407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 983 | N6-acetyllysineUniRule annotation1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P0A8T7 |
PaxDbi | P0A8T7 |
PRIDEi | P0A8T7 |
PTM databases
iPTMneti | P0A8T7 |
Interactioni
Subunit structurei
The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. The rRNA transcription and antitermination complex (rrnTAC) consists of RNAP, NusA, NusB, NusE (rpsJ), NusG, SubB, ribosomal protein S4, DNA and precursor rRNA; S4 is more flexible than other subunits (PubMed:32871103).
UniRule annotation4 PublicationsBinary interactionsi
P0A8T7
With | #Exp. | IntAct |
---|---|---|
adk [P69441] | 2 | EBI-543604,EBI-543592 |
htpG [P0A6Z3] | 3 | EBI-543604,EBI-369221 |
rpoB [P0A8V2] | 11 | EBI-543604,EBI-544996 |
rpoD [P00579] | 11 | EBI-543604,EBI-545104 |
uvrD [P03018] | 3 | EBI-543604,EBI-559573 |
Protein-protein interaction databases
BioGRIDi | 4262959, 70 interactors |
ComplexPortali | CPX-4881, DNA-directed RNA polymerase holoenzyme complex, Sigma70 variant CPX-4883, DNA-directed RNA polymerase holoenzyme complex, SigmaS variant CPX-4884, DNA-directed RNA polymerase holoenzyme complex, Sigma54 variant CPX-4885, DNA-directed RNA polymerase holoenzyme complex, SigmaE variant CPX-4886, DNA-directed RNA polymerase holoenzyme complex, SigmaF variant CPX-4887, DNA-directed RNA polymerase holoenzyme complex, SigmaH variant CPX-4888, DNA-directed RNA polymerase holoenzyme complex, Sigma fecI variant CPX-5674, Transcription elongation complex CPX-5780, lambdaN-dependent processive transcription antitermination complex |
DIPi | DIP-35803N |
IntActi | P0A8T7, 117 interactors |
MINTi | P0A8T7 |
STRINGi | 511145.b3988 |
Chemistry databases
BindingDBi | P0A8T7 |
Structurei
Secondary structure
3D structure databases
SMRi | P0A8T7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A8T7 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0086, Bacteria |
HOGENOMi | CLU_000524_3_1_6 |
InParanoidi | P0A8T7 |
PhylomeDBi | P0A8T7 |
Family and domain databases
Gene3Di | 1.10.132.30, 1 hit 1.10.274.100, 1 hit 4.10.860.120, 1 hit |
HAMAPi | MF_01322, RNApol_bact_RpoC, 1 hit |
InterProi | View protein in InterPro IPR045867, DNA-dir_RpoC_beta_prime IPR012754, DNA-dir_RpoC_beta_prime_bact IPR000722, RNA_pol_asu IPR006592, RNA_pol_N IPR007080, RNA_pol_Rpb1_1 IPR007066, RNA_pol_Rpb1_3 IPR042102, RNA_pol_Rpb1_3_sf IPR007083, RNA_pol_Rpb1_4 IPR007081, RNA_pol_Rpb1_5 IPR044893, RNA_pol_Rpb1_clamp_domain IPR038120, Rpb1_funnel_sf |
PANTHERi | PTHR19376, PTHR19376, 1 hit |
Pfami | View protein in Pfam PF04997, RNA_pol_Rpb1_1, 1 hit PF00623, RNA_pol_Rpb1_2, 2 hits PF04983, RNA_pol_Rpb1_3, 1 hit PF05000, RNA_pol_Rpb1_4, 1 hit PF04998, RNA_pol_Rpb1_5, 1 hit |
SMARTi | View protein in SMART SM00663, RPOLA_N, 1 hit |
TIGRFAMsi | TIGR02386, rpoC_TIGR, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MKDLLKFLKA QTKTEEFDAI KIALASPDMI RSWSFGEVKK PETINYRTFK
60 70 80 90 100
PERDGLFCAR IFGPVKDYEC LCGKYKRLKH RGVICEKCGV EVTQTKVRRE
110 120 130 140 150
RMGHIELASP TAHIWFLKSL PSRIGLLLDM PLRDIERVLY FESYVVIEGG
160 170 180 190 200
MTNLERQQIL TEEQYLDALE EFGDEFDAKM GAEAIQALLK SMDLEQECEQ
210 220 230 240 250
LREELNETNS ETKRKKLTKR IKLLEAFVQS GNKPEWMILT VLPVLPPDLR
260 270 280 290 300
PLVPLDGGRF ATSDLNDLYR RVINRNNRLK RLLDLAAPDI IVRNEKRMLQ
310 320 330 340 350
EAVDALLDNG RRGRAITGSN KRPLKSLADM IKGKQGRFRQ NLLGKRVDYS
360 370 380 390 400
GRSVITVGPY LRLHQCGLPK KMALELFKPF IYGKLELRGL ATTIKAAKKM
410 420 430 440 450
VEREEAVVWD ILDEVIREHP VLLNRAPTLH RLGIQAFEPV LIEGKAIQLH
460 470 480 490 500
PLVCAAYNAD FDGDQMAVHV PLTLEAQLEA RALMMSTNNI LSPANGEPII
510 520 530 540 550
VPSQDVVLGL YYMTRDCVNA KGEGMVLTGP KEAERLYRSG LASLHARVKV
560 570 580 590 600
RITEYEKDAN GELVAKTSLK DTTVGRAILW MIVPKGLPYS IVNQALGKKA
610 620 630 640 650
ISKMLNTCYR ILGLKPTVIF ADQIMYTGFA YAARSGASVG IDDMVIPEKK
660 670 680 690 700
HEIISEAEAE VAEIQEQFQS GLVTAGERYN KVIDIWAAAN DRVSKAMMDN
710 720 730 740 750
LQTETVINRD GQEEKQVSFN SIYMMADSGA RGSAAQIRQL AGMRGLMAKP
760 770 780 790 800
DGSIIETPIT ANFREGLNVL QYFISTHGAR KGLADTALKT ANSGYLTRRL
810 820 830 840 850
VDVAQDLVVT EDDCGTHEGI MMTPVIEGGD VKEPLRDRVL GRVTAEDVLK
860 870 880 890 900
PGTADILVPR NTLLHEQWCD LLEENSVDAV KVRSVVSCDT DFGVCAHCYG
910 920 930 940 950
RDLARGHIIN KGEAIGVIAA QSIGEPGTQL TMRTFHIGGA ASRAAAESSI
960 970 980 990 1000
QVKNKGSIKL SNVKSVVNSS GKLVITSRNT ELKLIDEFGR TKESYKVPYG
1010 1020 1030 1040 1050
AVLAKGDGEQ VAGGETVANW DPHTMPVITE VSGFVRFTDM IDGQTITRQT
1060 1070 1080 1090 1100
DELTGLSSLV VLDSAERTAG GKDLRPALKI VDAQGNDVLI PGTDMPAQYF
1110 1120 1130 1140 1150
LPGKAIVQLE DGVQISSGDT LARIPQESGG TKDITGGLPR VADLFEARRP
1160 1170 1180 1190 1200
KEPAILAEIS GIVSFGKETK GKRRLVITPV DGSDPYEEMI PKWRQLNVFE
1210 1220 1230 1240 1250
GERVERGDVI SDGPEAPHDI LRLRGVHAVT RYIVNEVQDV YRLQGVKIND
1260 1270 1280 1290 1300
KHIEVIVRQM LRKATIVNAG SSDFLEGEQV EYSRVKIANR ELEANGKVGA
1310 1320 1330 1340 1350
TYSRDLLGIT KASLATESFI SAASFQETTR VLTEAAVAGK RDELRGLKEN
1360 1370 1380 1390 1400
VIVGRLIPAG TGYAYHQDRM RRRAAGEAPA APQVTAEDAS ASLAELLNAG
LGGSDNE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1133 – 1177 | DITGG…RRLVI → ASPVVCRALRTCSKHVVRKS RQSWLKSAVSFPSVKKPKVN VVWLS no nucleotide entry (PubMed:6278450).CuratedAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00339 Genomic DNA Translation: CAA23626.1 U00006 Genomic DNA Translation: AAC43086.1 U00096 Genomic DNA Translation: AAC76962.1 AP009048 Genomic DNA Translation: BAE77332.1 M38293 Genomic DNA Translation: AAA24582.1 M38303 Genomic DNA Translation: AAA24584.1 V00340 Genomic DNA Translation: CAA23628.1 M38305 Genomic DNA Translation: AAA24586.1 M38288 Genomic DNA Translation: AAA24408.1 |
PIRi | A00695, RNECC |
RefSeqi | NP_418415.1, NC_000913.3 WP_000653944.1, NZ_STEB01000045.1 |
Genome annotation databases
EnsemblBacteriai | AAC76962; AAC76962; b3988 BAE77332; BAE77332; BAE77332 |
GeneIDi | 66672101 948487 |
KEGGi | ecj:JW3951 eco:b3988 |
PATRICi | fig|1411691.4.peg.2724 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00339 Genomic DNA Translation: CAA23626.1 U00006 Genomic DNA Translation: AAC43086.1 U00096 Genomic DNA Translation: AAC76962.1 AP009048 Genomic DNA Translation: BAE77332.1 M38293 Genomic DNA Translation: AAA24582.1 M38303 Genomic DNA Translation: AAA24584.1 V00340 Genomic DNA Translation: CAA23628.1 M38305 Genomic DNA Translation: AAA24586.1 M38288 Genomic DNA Translation: AAA24408.1 |
PIRi | A00695, RNECC |
RefSeqi | NP_418415.1, NC_000913.3 WP_000653944.1, NZ_STEB01000045.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2AUK | X-ray | 2.30 | A/B/C/D/E | 944-1129 | [»] | |
2LMC | NMR | - | B | 1151-1213 | [»] | |
3IYD | electron microscopy | - | D | 1-1407 | [»] | |
3LU0 | electron microscopy | - | D | 1-1407 | [»] | |
4IQZ | X-ray | 2.10 | A/B/C/D/E | 932-1141 | [»] | |
4JK1 | X-ray | 3.90 | D/I | 1-1407 | [»] | |
4JK2 | X-ray | 4.20 | D/I | 1-1407 | [»] | |
4KMU | X-ray | 3.85 | D/I | 1-1407 | [»] | |
4KN4 | X-ray | 3.96 | D/I | 1-1407 | [»] | |
4KN7 | X-ray | 3.69 | D/I | 1-1407 | [»] | |
4MEX | X-ray | 3.90 | D/J | 1-1407 | [»] | |
4MEY | X-ray | 3.95 | D/J | 1-1407 | [»] | |
4XSX | X-ray | 3.71 | D/J | 1-1407 | [»] | |
4XSY | X-ray | 4.01 | D/J | 1-1407 | [»] | |
4XSZ | X-ray | 3.68 | D/J | 1-1407 | [»] | |
4YG2 | X-ray | 3.70 | D/J | 1-1407 | [»] | |
4YLN | X-ray | 5.50 | D/J/P | 1-1407 | [»] | |
4YLO | X-ray | 6.00 | D/J/P | 1-1407 | [»] | |
4YLP | X-ray | 5.50 | D/J/P | 1-1407 | [»] | |
4ZH2 | X-ray | 4.20 | D/J | 1-1407 | [»] | |
4ZH3 | X-ray | 4.08 | D/J | 1-1407 | [»] | |
4ZH4 | X-ray | 3.99 | D/J | 1-1407 | [»] | |
5BYH | X-ray | 3.76 | D | 1-1407 | [»] | |
5EZK | X-ray | 8.50 | D | 1-1407 | [»] | |
5IPL | X-ray | 3.60 | D | 1-1407 | [»] | |
5IPM | X-ray | 4.20 | D | 1-1407 | [»] | |
5IPN | X-ray | 4.61 | D | 1-1407 | [»] | |
5MS0 | electron microscopy | 9.80 | D | 1-1407 | [»] | |
5MY1 | electron microscopy | 7.60 | Y | 1-1407 | [»] | |
5NSR | electron microscopy | 3.80 | D | 1-1407 | [»] | |
5NSS | electron microscopy | 5.80 | D | 1-1407 | [»] | |
5NWT | X-ray | 3.76 | D | 1-1407 | [»] | |
5UAC | X-ray | 3.80 | D/J | 1-1407 | [»] | |
5UAG | X-ray | 3.40 | D/J | 1-1407 | [»] | |
5UAH | X-ray | 4.10 | D/J | 1-1407 | [»] | |
5UAJ | X-ray | 3.92 | D/J | 1-1407 | [»] | |
5UAL | X-ray | 3.89 | D/J | 1-1407 | [»] | |
5UAQ | X-ray | 3.60 | D/J | 1-1407 | [»] | |
5VSW | X-ray | 4.29 | D/J | 1-1407 | [»] | |
5VT0 | electron microscopy | 3.78 | J | 1-1407 | [»] | |
5W1S | X-ray | 3.81 | D/J | 1-1407 | [»] | |
5W1T | X-ray | 4.50 | D/J | 1-1407 | [»] | |
6ALF | electron microscopy | 4.10 | J | 1-1407 | [»] | |
6ALG | electron microscopy | 3.70 | J | 1-1407 | [»] | |
6ALH | electron microscopy | 4.40 | J | 1-1407 | [»] | |
6ASX | electron microscopy | 3.80 | J | 1-1407 | [»] | |
6BJS | electron microscopy | 5.50 | J | 1-1407 | [»] | |
6BYU | X-ray | 3.60 | D/J | 1-1407 | [»] | |
6C6S | electron microscopy | 3.70 | J | 1-1407 | [»] | |
6C6T | electron microscopy | 3.50 | J | 1-1407 | [»] | |
6C6U | electron microscopy | 3.70 | J | 1-1407 | [»] | |
6C9Y | electron microscopy | 4.25 | D | 1-1407 | [»] | |
6CA0 | electron microscopy | 5.75 | D | 1-1407 | [»] | |
6CUX | X-ray | 4.10 | D/J | 1-1407 | [»] | |
6FLP | electron microscopy | 4.10 | D | 1-1407 | [»] | |
6FLQ | electron microscopy | 4.10 | D | 1-1407 | [»] | |
6GFW | electron microscopy | 3.70 | D | 1-1407 | [»] | |
6GH5 | electron microscopy | 3.40 | D | 1-1407 | [»] | |
6GH6 | electron microscopy | 4.10 | D | 1-1407 | [»] | |
6JBQ | electron microscopy | 4.02 | D | 1-1407 | [»] | |
6JNX | electron microscopy | 4.08 | D | 1-1407 | [»] | |
6K4Y | electron microscopy | 3.79 | D | 1-1407 | [»] | |
6KJ6 | electron microscopy | 3.80 | D | 1-1407 | [»] | |
6LDI | electron microscopy | 3.69 | D | 1-1407 | [»] | |
6N4C | electron microscopy | 17.00 | D | 15-1376 | [»] | |
6N57 | electron microscopy | 3.70 | J | 2-1407 | [»] | |
6N58 | electron microscopy | 3.78 | J | 2-1407 | [»] | |
6N60 | X-ray | 3.68 | D | 2-1407 | [»] | |
6N61 | X-ray | 3.25 | D | 2-1407 | [»] | |
6OMF | electron microscopy | 3.26 | D | 1-1407 | [»] | |
6P18 | electron microscopy | 3.50 | D | 1-1407 | [»] | |
6P19 | electron microscopy | 3.80 | D | 1-1407 | [»] | |
6P1K | electron microscopy | 4.05 | J | 2-1407 | [»] | |
6PSQ | electron microscopy | 3.40 | J | 2-1407 | [»] | |
6PSR | electron microscopy | 3.40 | J | 2-1407 | [»] | |
6PSS | electron microscopy | 3.50 | J | 2-1407 | [»] | |
6PST | electron microscopy | 3.00 | J | 2-1407 | [»] | |
6PSU | electron microscopy | 3.90 | J | 2-1407 | [»] | |
6PSV | electron microscopy | 3.50 | J | 2-1407 | [»] | |
6PSW | electron microscopy | 3.70 | J | 2-1407 | [»] | |
6R9B | electron microscopy | 3.80 | D | 1-1407 | [»] | |
6R9G | electron microscopy | 3.70 | D | 1-1407 | [»] | |
6RH3 | electron microscopy | 3.60 | D | 1-1407 | [»] | |
6RI7 | electron microscopy | 3.90 | D | 1-1407 | [»] | |
6RI9 | electron microscopy | 3.70 | D | 1-1407 | [»] | |
6RIN | electron microscopy | 3.70 | D | 1-1407 | [»] | |
6RIP | electron microscopy | 3.40 | D | 1-1407 | [»] | |
6TQN | electron microscopy | 3.80 | Y | 1-1407 | [»] | |
6TQO | electron microscopy | 4.00 | Y | 1-1407 | [»] | |
6UTV | X-ray | 3.45 | DDD | 1-1407 | [»] | |
6UTW | X-ray | 3.85 | DDD | 1-1407 | [»] | |
6UTX | X-ray | 4.05 | DDD | 1-1407 | [»] | |
6UTY | X-ray | 4.15 | DDD | 1-1407 | [»] | |
6UTZ | X-ray | 3.80 | DDD | 1-1407 | [»] | |
6UU0 | X-ray | 3.90 | DDD | 1-1407 | [»] | |
6UU1 | X-ray | 4.10 | DDD | 1-1407 | [»] | |
6UU2 | X-ray | 4.40 | DDD | 1-1407 | [»] | |
6UU3 | X-ray | 4.00 | DDD | 1-1407 | [»] | |
6UU4 | X-ray | 4.30 | DDD | 1-1407 | [»] | |
6UU5 | X-ray | 5.40 | DDD | 1-1407 | [»] | |
6UU6 | X-ray | 4.20 | DDD | 1-1407 | [»] | |
6UU7 | X-ray | 4.40 | DDD | 1-1407 | [»] | |
6UU8 | X-ray | 4.40 | DDD | 1-1407 | [»] | |
6UU9 | X-ray | 5.40 | DDD | 1-1407 | [»] | |
6UUA | X-ray | 4.00 | DDD | 1-1407 | [»] | |
6UUB | X-ray | 3.96 | DDD | 1-1407 | [»] | |
6UUC | X-ray | 4.10 | DDD | 1-1407 | [»] | |
6VJS | X-ray | 4.02 | D/I | 1-1407 | [»] | |
6WMU | electron microscopy | 3.18 | D | 1-1407 | [»] | |
6XAS | electron microscopy | 3.80 | J | 2-1407 | [»] | |
6XAV | electron microscopy | 7.70 | J | 2-1407 | [»] | |
6XH7 | electron microscopy | 3.90 | D | 1-1407 | [»] | |
6XH8 | electron microscopy | 4.10 | D | 1-1407 | [»] | |
6XL5 | electron microscopy | 2.50 | D | 1-1407 | [»] | |
6XL9 | electron microscopy | 2.50 | D | 1-1407 | [»] | |
6XLJ | electron microscopy | 2.70 | D | 1-1407 | [»] | |
6XLL | electron microscopy | 2.70 | D | 1-1407 | [»] | |
6XLM | electron microscopy | 3.20 | D | 1-1407 | [»] | |
6XLN | electron microscopy | 2.80 | D | 1-1407 | [»] | |
7C17 | electron microscopy | 4.22 | D | 1-1407 | [»] | |
7C97 | electron microscopy | 3.68 | D | 1-1407 | [»] | |
7CHW | electron microscopy | 3.58 | D | 1-1407 | [»] | |
7KHB | electron microscopy | 3.53 | D | 1-1407 | [»] | |
7KHC | electron microscopy | 4.14 | D | 1-1407 | [»] | |
7KHE | electron microscopy | 3.58 | D | 1-1407 | [»] | |
7KHI | electron microscopy | 3.62 | D | 1-1407 | [»] | |
7MKN | electron microscopy | 3.30 | D | 14-1376 | [»] | |
7MKO | electron microscopy | 3.15 | D | 14-1376 | [»] | |
7MKQ | electron microscopy | 4.80 | D | 14-1376 | [»] | |
SMRi | P0A8T7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262959, 70 interactors |
ComplexPortali | CPX-4881, DNA-directed RNA polymerase holoenzyme complex, Sigma70 variant CPX-4883, DNA-directed RNA polymerase holoenzyme complex, SigmaS variant CPX-4884, DNA-directed RNA polymerase holoenzyme complex, Sigma54 variant CPX-4885, DNA-directed RNA polymerase holoenzyme complex, SigmaE variant CPX-4886, DNA-directed RNA polymerase holoenzyme complex, SigmaF variant CPX-4887, DNA-directed RNA polymerase holoenzyme complex, SigmaH variant CPX-4888, DNA-directed RNA polymerase holoenzyme complex, Sigma fecI variant CPX-5674, Transcription elongation complex CPX-5780, lambdaN-dependent processive transcription antitermination complex |
DIPi | DIP-35803N |
IntActi | P0A8T7, 117 interactors |
MINTi | P0A8T7 |
STRINGi | 511145.b3988 |
Chemistry databases
BindingDBi | P0A8T7 |
ChEMBLi | CHEMBL2364672 CHEMBL4296169 |
DrugBanki | DB00615, Rifabutin DB11753, Rifamycin |
DrugCentrali | P0A8T7 |
PTM databases
iPTMneti | P0A8T7 |
Proteomic databases
jPOSTi | P0A8T7 |
PaxDbi | P0A8T7 |
PRIDEi | P0A8T7 |
Protocols and materials databases
ABCDi | P0A8T7, 1 sequenced antibody |
Genome annotation databases
EnsemblBacteriai | AAC76962; AAC76962; b3988 BAE77332; BAE77332; BAE77332 |
GeneIDi | 66672101 948487 |
KEGGi | ecj:JW3951 eco:b3988 |
PATRICi | fig|1411691.4.peg.2724 |
Organism-specific databases
EchoBASEi | EB0888 |
Phylogenomic databases
eggNOGi | COG0086, Bacteria |
HOGENOMi | CLU_000524_3_1_6 |
InParanoidi | P0A8T7 |
PhylomeDBi | P0A8T7 |
Enzyme and pathway databases
BioCyci | EcoCyc:RPOC-MONOMER |
BRENDAi | 2.7.7.6, 2026 |
Miscellaneous databases
EvolutionaryTracei | P0A8T7 |
PROi | PR:P0A8T7 |
Family and domain databases
Gene3Di | 1.10.132.30, 1 hit 1.10.274.100, 1 hit 4.10.860.120, 1 hit |
HAMAPi | MF_01322, RNApol_bact_RpoC, 1 hit |
InterProi | View protein in InterPro IPR045867, DNA-dir_RpoC_beta_prime IPR012754, DNA-dir_RpoC_beta_prime_bact IPR000722, RNA_pol_asu IPR006592, RNA_pol_N IPR007080, RNA_pol_Rpb1_1 IPR007066, RNA_pol_Rpb1_3 IPR042102, RNA_pol_Rpb1_3_sf IPR007083, RNA_pol_Rpb1_4 IPR007081, RNA_pol_Rpb1_5 IPR044893, RNA_pol_Rpb1_clamp_domain IPR038120, Rpb1_funnel_sf |
PANTHERi | PTHR19376, PTHR19376, 1 hit |
Pfami | View protein in Pfam PF04997, RNA_pol_Rpb1_1, 1 hit PF00623, RNA_pol_Rpb1_2, 2 hits PF04983, RNA_pol_Rpb1_3, 1 hit PF05000, RNA_pol_Rpb1_4, 1 hit PF04998, RNA_pol_Rpb1_5, 1 hit |
SMARTi | View protein in SMART SM00663, RPOLA_N, 1 hit |
TIGRFAMsi | TIGR02386, rpoC_TIGR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RPOC_ECOLI | |
Accessioni | P0A8T7Primary (citable) accession number: P0A8T7 Secondary accession number(s): P00577 Q2M8S4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families