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Protein

ATP-dependent Clp protease adapter protein ClpS

Gene

clpS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.UniRule annotation1 Publication

GO - Molecular functioni

  • chaperone binding Source: EcoCyc

GO - Biological processi

  • protein catabolic process Source: InterPro
  • response to heat Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G6463-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease adapter protein ClpSUniRule annotation
Gene namesi
Name:clpSUniRule annotation
Synonyms:yljA
Ordered Locus Names:b0881, JW0865
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14241 clpS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002157071 – 106ATP-dependent Clp protease adapter protein ClpSAdd BLAST106

Proteomic databases

PaxDbiP0A8Q6
PRIDEiP0A8Q6

2D gel databases

SWISS-2DPAGEiP0A8Q6

Interactioni

Subunit structurei

Binds to the N-terminal domain of the chaperone ClpA.UniRule annotation2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261321, 77 interactors
852740, 1 interactor
DIPiDIP-35408N
IntActiP0A8Q6, 43 interactors
MINTiP0A8Q6
STRINGi316385.ECDH10B_0951

Structurei

Secondary structure

1106
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 20Combined sources8
Beta strandi28 – 33Combined sources6
Beta strandi36 – 38Combined sources3
Helixi40 – 51Combined sources12
Helixi55 – 68Combined sources14
Beta strandi69 – 76Combined sources8
Helixi78 – 94Combined sources17
Beta strandi100 – 105Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LZWX-ray2.50A1-106[»]
1MBUX-ray2.30C/D1-106[»]
1MBVX-ray3.30B1-106[»]
1MBXX-ray2.25C/D1-106[»]
1MG9X-ray2.30A1-106[»]
1R6OX-ray2.25C/D1-106[»]
1R6QX-ray2.35C/D1-106[»]
2W9RX-ray1.70A1-106[»]
2WA8X-ray2.15A/C1-106[»]
2WA9X-ray2.90A/B/C/D/E/F/G1-106[»]
3O1FX-ray1.40A/B26-106[»]
3O2BX-ray2.05A/C2-106[»]
3O2HX-ray1.70A2-106[»]
3O2OX-ray2.90A/B/C/D/E/F/G/H22-106[»]
ProteinModelPortaliP0A8Q6
SMRiP0A8Q6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8Q6

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KAE Bacteria
COG2127 LUCA
HOGENOMiHOG000247049
InParanoidiP0A8Q6
KOiK06891
OMAiERFFQKD
PhylomeDBiP0A8Q6

Family and domain databases

Gene3Di3.30.1390.10, 1 hit
HAMAPiMF_00302 ClpS, 1 hit
InterProiView protein in InterPro
IPR022935 ClpS
IPR003769 ClpS_core
IPR014719 Ribosomal_L7/12_C/ClpS-like
PfamiView protein in Pfam
PF02617 ClpS, 1 hit
SUPFAMiSSF54736 SSF54736, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTNDWLDF DQLAEEKVRD ALKPPSMYKV ILVNDDYTPM EFVIDVLQKF
60 70 80 90 100
FSYDVERATQ LMLAVHYQGK AICGVFTAEV AETKVAMVNK YARENEHPLL

CTLEKA
Length:106
Mass (Da):12,179
Last modified:June 7, 2005 - v1
Checksum:i2E9DC8000EA3CE86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73968.1
AP009048 Genomic DNA Translation: BAA35600.1
PIRiA64827
RefSeqiNP_415402.1, NC_000913.3
WP_000520781.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73968; AAC73968; b0881
BAA35600; BAA35600; BAA35600
GeneIDi948443
KEGGiecj:JW0865
eco:b0881
PATRICifig|1411691.4.peg.1396

Similar proteinsi

Entry informationi

Entry nameiCLPS_ECOLI
AccessioniPrimary (citable) accession number: P0A8Q6
Secondary accession number(s): P75832
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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