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Protein

Fumarate reductase subunit C

Gene

frdC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.

GO - Molecular functioni

  • succinate dehydrogenase (ubiquinone) activity Source: EcoCyc
  • succinate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  • anaerobic respiration Source: EcoCyc
  • bacterial-type flagellum assembly Source: EcoCyc
  • bacterial-type flagellum-dependent cell motility Source: EcoCyc
  • fermentation Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:FUM-MEMB1
MetaCyc:FUM-MEMB1

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase subunit C
Alternative name(s):
Fumarate reductase 15 kDa hydrophobic protein
Gene namesi
Name:frdC
Ordered Locus Names:b4152, JW4113
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10332 frdC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21Cytoplasmic1 PublicationAdd BLAST21
Transmembranei22 – 49HelicalAdd BLAST28
Topological domaini50 – 65Periplasmic1 PublicationAdd BLAST16
Transmembranei66 – 90HelicalAdd BLAST25
Topological domaini91 – 104Cytoplasmic1 PublicationAdd BLAST14
Transmembranei105 – 128HelicalAdd BLAST24
Topological domaini129 – 131Periplasmic1 Publication3

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
  • plasma membrane fumarate reductase complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB07918 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001965261 – 131Fumarate reductase subunit CAdd BLAST131

Proteomic databases

PaxDbiP0A8Q0
PRIDEiP0A8Q0

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

Protein-protein interaction databases

BioGridi4262700, 364 interactors
ComplexPortaliCPX-1967 Plasma membrane fumarate reductase complex
DIPiDIP-48082N
IntActiP0A8Q0, 3 interactors
STRINGi316385.ECDH10B_4347

Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 18Combined sources3
Helixi21 – 31Combined sources11
Helixi33 – 51Combined sources19
Helixi53 – 64Combined sources12
Helixi68 – 90Combined sources23
Helixi91 – 94Combined sources4
Beta strandi98 – 103Combined sources6
Helixi107 – 129Combined sources23

3D structure databases

ProteinModelPortaliP0A8Q0
SMRiP0A8Q0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8Q0

Family & Domainsi

Sequence similaritiesi

Belongs to the FrdC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108WJH Bacteria
COG3029 LUCA
HOGENOMiHOG000281484
InParanoidiP0A8Q0
KOiK00246
OMAiMTATWWQ

Family and domain databases

CDDicd00546 QFR_TypeD_subunitC, 1 hit
Gene3Di1.20.1300.10, 1 hit
HAMAPiMF_00708 Fumarate_red_C, 1 hit
InterProiView protein in InterPro
IPR003510 Fumarate_red_C
IPR034804 SQR/QFR_C/D
PfamiView protein in Pfam
PF02300 Fumarate_red_C, 1 hit
PIRSFiPIRSF000180 FrdC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015900 Fumarate_red_C, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKRKPYVR PMTSTWWKKL PFYRFYMLRE GTAVPAVWFS IELIFGLFAL
60 70 80 90 100
KNGPEAWAGF VDFLQNPVIV IINLITLAAA LLHTKTWFEL APKAANIIVK
110 120 130
DEKMGPEPII KSLWAVTVVA TIVILFVALY W
Length:131
Mass (Da):15,015
Last modified:July 21, 1986 - v1
Checksum:i26FDF83A2EF8EF43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01611 Genomic DNA Translation: AAA23439.1
V00277 Genomic DNA Translation: CAA23535.1
U14003 Genomic DNA Translation: AAA97051.1
U00096 Genomic DNA Translation: AAC77112.1
AP009048 Genomic DNA Translation: BAE78156.1
PIRiS56380
RefSeqiNP_418576.1, NC_000913.3
WP_000208757.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77112; AAC77112; b4152
BAE78156; BAE78156; BAE78156
GeneIDi948680
KEGGiecj:JW4113
eco:b4152
PATRICifig|1411691.4.peg.2546

Similar proteinsi

Entry informationi

Entry nameiFRDC_ECOLI
AccessioniPrimary (citable) accession number: P0A8Q0
Secondary accession number(s): P03805, Q2M6F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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