UniProtKB - P0A8N0 (MATP_ECOLI)
Protein
Macrodomain Ter protein
Gene
matP
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.UniRule annotation1 Publication
GO - Molecular functioni
- sequence-specific DNA binding Source: EcoCyc
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: EcoCyc
- chromosome organization Source: EcoCyc
- chromosome segregation Source: EcoCyc
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12855-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Macrodomain Ter proteinUniRule annotation |
Gene namesi | Name:matPUniRule annotation Synonyms:ycbG Ordered Locus Names:b0956, JW0939 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation1 Publication
Note: Accumulates in the cell as a discrete focus that colocalizes with the Ter macrodomain.
Other locations
- cytoplasm Source: UniProtKB-SubCell
- DNA replication termination region Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Mutants grown in rich medium show severe defects in chromosome segregation and cell division.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070347 | 1 – 150 | Macrodomain Ter proteinAdd BLAST | 150 |
Proteomic databases
jPOSTi | P0A8N0 |
PaxDbi | P0A8N0 |
PRIDEi | P0A8N0 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 4260031, 9 interactors 849944, 12 interactors |
IntActi | P0A8N0, 24 interactors |
STRINGi | 511145.b0956 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MatP family.UniRule annotation
Phylogenomic databases
eggNOGi | COG3120, Bacteria |
HOGENOMi | CLU_142157_0_0_6 |
Family and domain databases
Gene3Di | 1.10.1220.10, 1 hit 1.20.1270.380, 1 hit |
HAMAPi | MF_01073, MatP, 1 hit |
InterProi | View protein in InterPro IPR013321, Arc_rbn_hlx_hlx IPR009390, MatP IPR035375, MatP_C IPR035087, MatP_N IPR038339, MatP_N_sf |
Pfami | View protein in Pfam PF06303, MatP, 1 hit PF17414, MatP_C, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A8N0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKYQQLENLE SGWKWKYLVK KHREGELITR YIEASAAQEA VDVLLSLENE
60 70 80 90 100
PVLVNGWIDK HMNPELVNRM KQTIRARRKR HFNAEHQHTR KKSIDLEFIV
110 120 130 140 150
WQRLAGLAQR RGKTLSETIV QLIEDAENKE KYANKMSSLK QDLQALLGKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74042.1 AP009048 Genomic DNA Translation: BAA35714.1 V00307 Genomic DNA No translation available. |
PIRi | C64836 |
RefSeqi | NP_415476.1, NC_000913.3 WP_000877161.1, NZ_STEB01000006.1 |
Genome annotation databases
EnsemblBacteriai | AAC74042; AAC74042; b0956 BAA35714; BAA35714; BAA35714 |
GeneIDi | 58461146 945570 |
KEGGi | ecj:JW0939 eco:b0956 |
PATRICi | fig|1411691.4.peg.1318 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74042.1 AP009048 Genomic DNA Translation: BAA35714.1 V00307 Genomic DNA No translation available. |
PIRi | C64836 |
RefSeqi | NP_415476.1, NC_000913.3 WP_000877161.1, NZ_STEB01000006.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4D8J | X-ray | 3.55 | A/B/C/D/G/H/K/L | 1-150 | [»] | |
SMRi | P0A8N0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260031, 9 interactors 849944, 12 interactors |
IntActi | P0A8N0, 24 interactors |
STRINGi | 511145.b0956 |
Proteomic databases
jPOSTi | P0A8N0 |
PaxDbi | P0A8N0 |
PRIDEi | P0A8N0 |
Genome annotation databases
EnsemblBacteriai | AAC74042; AAC74042; b0956 BAA35714; BAA35714; BAA35714 |
GeneIDi | 58461146 945570 |
KEGGi | ecj:JW0939 eco:b0956 |
PATRICi | fig|1411691.4.peg.1318 |
Organism-specific databases
EchoBASEi | EB2699 |
Phylogenomic databases
eggNOGi | COG3120, Bacteria |
HOGENOMi | CLU_142157_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12855-MONOMER |
Miscellaneous databases
PROi | PR:P0A8N0 |
Gene expression databases
CollecTFi | EXPREG_000007b0 |
Family and domain databases
Gene3Di | 1.10.1220.10, 1 hit 1.20.1270.380, 1 hit |
HAMAPi | MF_01073, MatP, 1 hit |
InterProi | View protein in InterPro IPR013321, Arc_rbn_hlx_hlx IPR009390, MatP IPR035375, MatP_C IPR035087, MatP_N IPR038339, MatP_N_sf |
Pfami | View protein in Pfam PF06303, MatP, 1 hit PF17414, MatP_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MATP_ECOLI | |
Accessioni | P0A8N0Primary (citable) accession number: P0A8N0 Secondary accession number(s): P45569, P75868, Q83RX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families