UniProtKB - P0A8H8 (YACG_ECOLI)
Protein
DNA gyrase inhibitor YacG
Gene
yacG
Organism
Escherichia coli (strain K12)
Status
Functioni
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation1 Publication
Cofactori
Zn2+Note: Binds 1 zinc ion.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 9 | Zinc | 1 | |
Metal bindingi | 12 | Zinc | 1 | |
Metal bindingi | 28 | Zinc | 1 | |
Metal bindingi | 32 | Zinc | 1 |
GO - Molecular functioni
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity Source: EcoCyc
- zinc ion binding Source: EcoCyc
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12314-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA gyrase inhibitor YacGUniRule annotation |
Gene namesi | Name:yacGUniRule annotation Ordered Locus Names:b0101, JW5008 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211695 | 1 – 65 | DNA gyrase inhibitor YacGAdd BLAST | 65 |
Proteomic databases
jPOSTi | P0A8H8 |
PaxDbi | P0A8H8 |
PRIDEi | P0A8H8 |
Interactioni
Subunit structurei
Interacts with GyrB.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 4261884, 1 interactor |
DIPi | DIP-48126N |
IntActi | P0A8H8, 3 interactors |
STRINGi | 511145.b0101 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A8H8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A8H8 |
Family & Domainsi
Sequence similaritiesi
Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation
Phylogenomic databases
eggNOGi | COG3024, Bacteria |
HOGENOMi | CLU_178280_3_1_6 |
InParanoidi | P0A8H8 |
PhylomeDBi | P0A8H8 |
Family and domain databases
Gene3Di | 3.30.50.10, 1 hit |
HAMAPi | MF_00649, DNA_gyrase_inhibitor_YacG, 1 hit |
InterProi | View protein in InterPro IPR005584, DNA_gyrase_inhibitor_YacG IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR36150, PTHR36150, 1 hit |
Pfami | View protein in Pfam PF03884, YacG, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A8H8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSETITVNCP TCGKTVVWGE ISPFRPFCSK RCQLIDLGEW AAEEKRIPSS
60
GDLSESDDWS EEPKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73212.1 AP009048 Genomic DNA Translation: BAB96668.2 X04831 Genomic DNA No translation available. |
PIRi | E64732 |
RefSeqi | NP_414643.1, NC_000913.3 WP_000005042.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73212; AAC73212; b0101 BAB96668; BAB96668; BAB96668 |
GeneIDi | 49586087 945630 |
KEGGi | ecj:JW5008 eco:b0101 |
PATRICi | fig|1411691.4.peg.2180 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73212.1 AP009048 Genomic DNA Translation: BAB96668.2 X04831 Genomic DNA No translation available. |
PIRi | E64732 |
RefSeqi | NP_414643.1, NC_000913.3 WP_000005042.1, NZ_STEB01000010.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LV3 | NMR | - | A | 1-65 | [»] | |
4TMA | X-ray | 3.30 | I/J/K/L | 1-65 | [»] | |
SMRi | P0A8H8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261884, 1 interactor |
DIPi | DIP-48126N |
IntActi | P0A8H8, 3 interactors |
STRINGi | 511145.b0101 |
Proteomic databases
jPOSTi | P0A8H8 |
PaxDbi | P0A8H8 |
PRIDEi | P0A8H8 |
Protocols and materials databases
DNASUi | 945630 |
Genome annotation databases
EnsemblBacteriai | AAC73212; AAC73212; b0101 BAB96668; BAB96668; BAB96668 |
GeneIDi | 49586087 945630 |
KEGGi | ecj:JW5008 eco:b0101 |
PATRICi | fig|1411691.4.peg.2180 |
Organism-specific databases
EchoBASEi | EB2220 |
Phylogenomic databases
eggNOGi | COG3024, Bacteria |
HOGENOMi | CLU_178280_3_1_6 |
InParanoidi | P0A8H8 |
PhylomeDBi | P0A8H8 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12314-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A8H8 |
PROi | PR:P0A8H8 |
Family and domain databases
Gene3Di | 3.30.50.10, 1 hit |
HAMAPi | MF_00649, DNA_gyrase_inhibitor_YacG, 1 hit |
InterProi | View protein in InterPro IPR005584, DNA_gyrase_inhibitor_YacG IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR36150, PTHR36150, 1 hit |
Pfami | View protein in Pfam PF03884, YacG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YACG_ECOLI | |
Accessioni | P0A8H8Primary (citable) accession number: P0A8H8 Secondary accession number(s): P36681, P75644, Q8KJQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families