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Protein

Exodeoxyribonuclease 7 small subunit

Gene

xseB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions.

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.

GO - Molecular functioni

  • exodeoxyribonuclease VII activity Source: EcoliWiki

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:EG11098-MONOMER
MetaCyc:EG11098-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 small subunit (EC:3.1.11.6)
Alternative name(s):
Exodeoxyribonuclease VII small subunit
Short name:
Exonuclease VII small subunit
Gene namesi
Name:xseB
Synonyms:yajE
Ordered Locus Names:b0422, JW0412
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11098 xseB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • exodeoxyribonuclease VII complex Source: InterPro

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002069452 – 80Exodeoxyribonuclease 7 small subunitAdd BLAST79

Proteomic databases

PaxDbiP0A8G9
PRIDEiP0A8G9

Interactioni

Subunit structurei

Heterooligomer composed of two different subunits with an approximate ratio of 4 small subunits for 1 large.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
yebVP645034EBI-1116872,EBI-9126792

Protein-protein interaction databases

BioGridi4259844, 58 interactors
DIPiDIP-48031N
IntActiP0A8G9, 5 interactors
STRINGi316385.ECDH10B_0378

Structurei

3D structure databases

ProteinModelPortaliP0A8G9
SMRiP0A8G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseB family.Curated

Phylogenomic databases

eggNOGiENOG41067QG Bacteria
COG1722 LUCA
HOGENOMiHOG000228798
InParanoidiP0A8G9
KOiK03602
PhylomeDBiP0A8G9

Family and domain databases

Gene3Di1.10.287.1040, 1 hit
HAMAPiMF_00337 Exonuc_7_S, 1 hit
InterProiView protein in InterPro
IPR003761 Exonuc_VII_S
IPR037004 Exonuc_VII_ssu_sf
PANTHERiPTHR34137 PTHR34137, 1 hit
PfamiView protein in Pfam
PF02609 Exonuc_VII_S, 1 hit
PIRSFiPIRSF006488 Exonuc_VII_S, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028235 Exonuc_VII_S, 1 hit
TIGRFAMsiTIGR01280 xseB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A8G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKKNEAPAS FEKALSELEQ IVTRLESGDL PLEEALNEFE RGVQLARQGQ
60 70 80
AKLQQAEQRV QILLSDNEDA SLTPFTPDNE
Length:80
Mass (Da):8,952
Last modified:January 23, 2007 - v2
Checksum:i8B10380D442CADF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00694 Genomic DNA Translation: BAA00598.1
U82664 Genomic DNA Translation: AAB40178.1
U00096 Genomic DNA Translation: AAC73525.1
AP009048 Genomic DNA Translation: BAE76202.1
PIRiJQ0664
RefSeqiNP_414956.1, NC_000913.3
WP_001124935.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73525; AAC73525; b0422
BAE76202; BAE76202; BAE76202
GeneIDi945069
KEGGiecj:JW0412
eco:b0422
PATRICifig|1411691.4.peg.1855

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00694 Genomic DNA Translation: BAA00598.1
U82664 Genomic DNA Translation: AAB40178.1
U00096 Genomic DNA Translation: AAC73525.1
AP009048 Genomic DNA Translation: BAE76202.1
PIRiJQ0664
RefSeqiNP_414956.1, NC_000913.3
WP_001124935.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0A8G9
SMRiP0A8G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259844, 58 interactors
DIPiDIP-48031N
IntActiP0A8G9, 5 interactors
STRINGi316385.ECDH10B_0378

Proteomic databases

PaxDbiP0A8G9
PRIDEiP0A8G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73525; AAC73525; b0422
BAE76202; BAE76202; BAE76202
GeneIDi945069
KEGGiecj:JW0412
eco:b0422
PATRICifig|1411691.4.peg.1855

Organism-specific databases

EchoBASEiEB1090
EcoGeneiEG11098 xseB

Phylogenomic databases

eggNOGiENOG41067QG Bacteria
COG1722 LUCA
HOGENOMiHOG000228798
InParanoidiP0A8G9
KOiK03602
PhylomeDBiP0A8G9

Enzyme and pathway databases

BioCyciEcoCyc:EG11098-MONOMER
MetaCyc:EG11098-MONOMER

Miscellaneous databases

PROiPR:P0A8G9

Family and domain databases

Gene3Di1.10.287.1040, 1 hit
HAMAPiMF_00337 Exonuc_7_S, 1 hit
InterProiView protein in InterPro
IPR003761 Exonuc_VII_S
IPR037004 Exonuc_VII_ssu_sf
PANTHERiPTHR34137 PTHR34137, 1 hit
PfamiView protein in Pfam
PF02609 Exonuc_VII_S, 1 hit
PIRSFiPIRSF006488 Exonuc_VII_S, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028235 Exonuc_VII_S, 1 hit
TIGRFAMsiTIGR01280 xseB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEX7S_ECOLI
AccessioniPrimary (citable) accession number: P0A8G9
Secondary accession number(s): P22938, Q2MC04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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