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Entry version 121 (13 Nov 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Trp operon repressor

Gene

trpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.

Caution

PubMed:7841459 sequence was originally thought to originate from S.typhimurium, but seems to come from an unknown E.coli strain.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi68 – 91Add BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:PD00423
ECOL316407:JW4356-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trp operon repressor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpR
Synonyms:rtrY
Ordered Locus Names:b4393, JW4356
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001964942 – 108Trp operon repressorAdd BLAST107

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0A881

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A881

PRoteomics IDEntifications database

More...
PRIDEi
P0A881

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260801, 6 interactors
853194, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-48204N

Protein interaction database and analysis system

More...
IntActi
P0A881, 3 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b4393

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P0A881

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A881

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0A881

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TrpR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105R9M Bacteria
COG2973 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000288846

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A881

KEGG Orthology (KO)

More...
KOi
K03720

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1270.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00475 Trp_repressor, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000831 Trp_repress
IPR013335 Trp_repress_bac
IPR010921 Trp_repressor/repl_initiator
IPR038116 TrpR-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR38025 PTHR38025, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01371 Trp_repressor, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003196 Trp_repressor, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48295 SSF48295, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01321 TrpR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0A881-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA
60 70 80 90 100
LGTRVRIVEE LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL

EEVLLKSD
Length:108
Mass (Da):12,355
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDFF8A60EC4FE7BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26L → V in AAA72134 (PubMed:7841459).Curated1
Sequence conflicti56R → A in AAA72134 (PubMed:7841459).Curated1
Sequence conflicti100L → M in AAA72134 (PubMed:7841459).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01715 Genomic DNA Translation: AAA72140.1
L13768 Genomic DNA Translation: AAA72134.1
U14003 Genomic DNA Translation: AAA97289.1
U00096 Genomic DNA Translation: AAC77346.1
AP009048 Genomic DNA Translation: BAE78382.1
M69185 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
A03568 RPECW

NCBI Reference Sequences

More...
RefSeqi
NP_418810.1, NC_000913.3
WP_000068679.1, NZ_STEB01000033.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC77346; AAC77346; b4393
BAE78382; BAE78382; BAE78382

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948917

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW4356
eco:b4393

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.4542

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01715 Genomic DNA Translation: AAA72140.1
L13768 Genomic DNA Translation: AAA72134.1
U14003 Genomic DNA Translation: AAA97289.1
U00096 Genomic DNA Translation: AAC77346.1
AP009048 Genomic DNA Translation: BAE78382.1
M69185 Genomic DNA No translation available.
PIRiA03568 RPECW
RefSeqiNP_418810.1, NC_000913.3
WP_000068679.1, NZ_STEB01000033.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CO0NMR-A/B2-108[»]
1JHGX-ray1.30A8-108[»]
1MI7X-ray2.50R2-108[»]
1RCSNMR-A/B4-107[»]
1TROX-ray1.90A/C/E/G1-108[»]
1TRRX-ray2.40A/B/D/E/G/H/J/K2-108[»]
1WRPX-ray2.20R2-108[»]
1WRSNMR-R/S4-108[»]
1WRTNMR-R/S4-108[»]
1ZT9X-ray2.00A/B/D/E2-108[»]
2OZ9X-ray1.65R2-108[»]
3SSWX-ray1.67N/R2-108[»]
3SSXX-ray1.58N/R2-108[»]
3WRPX-ray1.80A1-108[»]
6EJWX-ray1.99A/B/C/D1-108[»]
6EKPX-ray1.46A/B1-108[»]
6ELBX-ray1.44A/B1-108[»]
6ELFX-ray1.83A/B1-108[»]
6ELGX-ray1.38A/B1-108[»]
6ENIX-ray1.10A/B1-108[»]
6ENNX-ray1.17A/B1-108[»]
6F7FX-ray2.13A/B/C/D4-106[»]
6F7GX-ray1.66A/C4-106[»]
6F9KX-ray1.40A1-107[»]
6FALX-ray1.20A/B2-108[»]
SMRiP0A881
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260801, 6 interactors
853194, 1 interactor
DIPiDIP-48204N
IntActiP0A881, 3 interactors
STRINGi511145.b4393

Chemistry databases

BindingDBiP0A881

Proteomic databases

jPOSTiP0A881
PaxDbiP0A881
PRIDEiP0A881

Genome annotation databases

EnsemblBacteriaiAAC77346; AAC77346; b4393
BAE78382; BAE78382; BAE78382
GeneIDi948917
KEGGiecj:JW4356
eco:b4393
PATRICifig|511145.12.peg.4542

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1022

Phylogenomic databases

eggNOGiENOG4105R9M Bacteria
COG2973 LUCA
HOGENOMiHOG000288846
InParanoidiP0A881
KOiK03720

Enzyme and pathway databases

BioCyciEcoCyc:PD00423
ECOL316407:JW4356-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A881

Protein Ontology

More...
PROi
PR:P0A881

Family and domain databases

Gene3Di1.10.1270.10, 1 hit
HAMAPiMF_00475 Trp_repressor, 1 hit
InterProiView protein in InterPro
IPR000831 Trp_repress
IPR013335 Trp_repress_bac
IPR010921 Trp_repressor/repl_initiator
IPR038116 TrpR-like_sf
PANTHERiPTHR38025 PTHR38025, 1 hit
PfamiView protein in Pfam
PF01371 Trp_repressor, 1 hit
PIRSFiPIRSF003196 Trp_repressor, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
TIGRFAMsiTIGR01321 TrpR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPR_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A881
Secondary accession number(s): P03032, Q2M5S4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 13, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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