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Protein

DNA-directed RNA polymerase subunit omega

Gene

rpoZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • protein-containing complex assembly Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-UniRule

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10899-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit omega (EC:2.7.7.6)
Short name:
RNAP omega subunit
Alternative name(s):
RNA polymerase omega subunit
Transcriptase subunit omega
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpoZ
Ordered Locus Names:b3649, JW3624
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10899 rpoZ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • RNA polymerase complex Source: EcoliWiki

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001289352 – 91DNA-directed RNA polymerase subunit omegaAdd BLAST90

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0A800

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A800

PRoteomics IDEntifications database

More...
PRIDEi
P0A800

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259347, 290 interactors

Database of interacting proteins

More...
DIPi
DIP-31837N

Protein interaction database and analysis system

More...
IntActi
P0A800, 27 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_3831

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P0A800

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0A800

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A800

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0A800

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105VFG Bacteria
COG1758 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000245721

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A800

KEGG Orthology (KO)

More...
KOi
K03060

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0A800

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.940.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00366 RNApol_bact_RpoZ, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003716 DNA-dir_RNA_pol_omega
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR036161 RPB6/omega_like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR34476 PTHR34476, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01409 RNA_pol_Rpb6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63562 SSF63562, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00690 rpoZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0A800-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARVTVQDAV EKIGNRFDLV LVAARRARQM QVGGKDPLVP EENDKTTVIA
60 70 80 90
LREIEEGLIN NQILDVRERQ EQQEQEAAEL QAVTAIAEGR R
Length:91
Mass (Da):10,237
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DE7E81EF670D887
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M24503 Genomic DNA Translation: AAB00159.1
M15266 Genomic DNA Translation: AAA24229.1
L10328 Genomic DNA Translation: AAA62002.1
U00096 Genomic DNA Translation: AAC76673.1
AP009048 Genomic DNA Translation: BAE77644.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A29038 RNECO

NCBI Reference Sequences

More...
RefSeqi
NP_418106.1, NC_000913.3
WP_000135058.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76673; AAC76673; b3649
BAE77644; BAE77644; BAE77644

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34153435
948160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3624
eco:b3649

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3769

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24503 Genomic DNA Translation: AAB00159.1
M15266 Genomic DNA Translation: AAA24229.1
L10328 Genomic DNA Translation: AAA62002.1
U00096 Genomic DNA Translation: AAC76673.1
AP009048 Genomic DNA Translation: BAE77644.1
PIRiA29038 RNECO
RefSeqiNP_418106.1, NC_000913.3
WP_000135058.1, NZ_LN832404.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IYDelectron microscopy-E2-91[»]
3LU0electron microscopy-E1-91[»]
4JK1X-ray3.90E/J1-91[»]
4JK2X-ray4.20E/J1-91[»]
4KMUX-ray3.85E/J1-91[»]
4KN4X-ray3.96E/J1-91[»]
4KN7X-ray3.69E/J1-91[»]
4MEXX-ray3.90E/K1-91[»]
4MEYX-ray3.95E/K1-91[»]
4XSXX-ray3.71E/K1-91[»]
4XSYX-ray4.01E/K1-91[»]
4XSZX-ray3.68E/K1-91[»]
4YG2X-ray3.70E/K1-91[»]
4YLNX-ray5.50E/K/Q2-91[»]
4YLOX-ray6.00E/K/Q2-91[»]
4YLPX-ray5.50E/K/Q2-91[»]
4ZH2X-ray4.20E/K1-91[»]
4ZH3X-ray4.08E/K1-91[»]
4ZH4X-ray3.99E/K1-91[»]
5BYHX-ray3.76E1-91[»]
5EZKX-ray8.50E1-91[»]
5IPLX-ray3.60E2-91[»]
5IPMX-ray4.20E2-91[»]
5IPNX-ray4.61E2-91[»]
5MS0electron microscopy9.80O1-91[»]
5MY1electron microscopy7.60Z1-91[»]
5NSRelectron microscopy3.80E1-91[»]
5NSSelectron microscopy5.80E1-91[»]
5NWTX-ray3.76E1-91[»]
5UACX-ray3.80E/K1-91[»]
5UAGX-ray3.40E/K2-91[»]
5UAHX-ray4.10E/K1-91[»]
5UAJX-ray3.92E/K1-91[»]
5UALX-ray3.89E/K1-91[»]
5UAQX-ray3.60E/K1-91[»]
5VSWX-ray4.29E/K1-91[»]
5VT0electron microscopy3.78K1-91[»]
5W1SX-ray3.81E/K1-91[»]
5W1TX-ray4.50E/K1-91[»]
6ALFelectron microscopy4.10K1-80[»]
6ALGelectron microscopy3.74K1-91[»]
6ALHelectron microscopy4.40K1-80[»]
6ASXelectron microscopy3.80K1-84[»]
6BJSelectron microscopy5.50K1-91[»]
6BYUX-ray3.60E/K1-91[»]
6C6Selectron microscopy3.70K1-91[»]
6C6Telectron microscopy3.50K1-91[»]
6C6Uelectron microscopy3.70K1-91[»]
6C9Yelectron microscopy4.25E1-91[»]
6CA0electron microscopy5.75E1-91[»]
6CUXX-ray4.10E/K1-91[»]
6FLPelectron microscopy4.10E1-91[»]
6FLQelectron microscopy4.10E1-91[»]
6GFWelectron microscopy3.70E1-91[»]
6GH5electron microscopy3.40E1-91[»]
6GH6electron microscopy4.10E1-91[»]
ProteinModelPortaliP0A800
SMRiP0A800
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259347, 290 interactors
DIPiDIP-31837N
IntActiP0A800, 27 interactors
STRINGi316385.ECDH10B_3831

Chemistry databases

BindingDBiP0A800
ChEMBLiCHEMBL2364672

Proteomic databases

EPDiP0A800
PaxDbiP0A800
PRIDEiP0A800

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76673; AAC76673; b3649
BAE77644; BAE77644; BAE77644
GeneIDi34153435
948160
KEGGiecj:JW3624
eco:b3649
PATRICifig|511145.12.peg.3769

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0892
EcoGeneiEG10899 rpoZ

Phylogenomic databases

eggNOGiENOG4105VFG Bacteria
COG1758 LUCA
HOGENOMiHOG000245721
InParanoidiP0A800
KOiK03060
PhylomeDBiP0A800

Enzyme and pathway databases

BioCyciEcoCyc:EG10899-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A800

Protein Ontology

More...
PROi
PR:P0A800

Family and domain databases

Gene3Di3.90.940.10, 1 hit
HAMAPiMF_00366 RNApol_bact_RpoZ, 1 hit
InterProiView protein in InterPro
IPR003716 DNA-dir_RNA_pol_omega
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR036161 RPB6/omega_like_sf
PANTHERiPTHR34476 PTHR34476, 1 hit
PfamiView protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit
SMARTiView protein in SMART
SM01409 RNA_pol_Rpb6, 1 hit
SUPFAMiSSF63562 SSF63562, 1 hit
TIGRFAMsiTIGR00690 rpoZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOZ_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A800
Secondary accession number(s): P08374, Q2M7W2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: December 5, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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