UniProtKB - P0A7S3 (RS12_ECOLI)
30S ribosomal protein S12
rpsL
Functioni
With S4 and S5 plays an important role in translational accuracy.
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
By similarity1 PublicationCryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit.
1 PublicationMiscellaneous
GO - Molecular functioni
- misfolded RNA binding Source: EcoCyc
- rRNA binding Source: EcoCyc
- structural constituent of ribosome Source: CAFA
- tRNA binding Source: UniProtKB-UniRule
GO - Biological processi
- cytoplasmic translation Source: ComplexPortal
- Group I intron splicing Source: EcoCyc
- maintenance of translational fidelity Source: EcoCyc
- positive regulation of RNA splicing Source: EcoCyc
- response to antibiotic Source: UniProtKB-KW
- RNA folding Source: EcoCyc
- translation Source: EcoCyc
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding |
Biological process | Antibiotic resistance |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10911-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 30S ribosomal protein S12Alternative name(s): Small ribosomal subunit protein uS121 Publication |
Gene namesi | Name:rpsL Synonyms:strA Ordered Locus Names:b3342, JW3304 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: EcoCyc
- cytosolic small ribosomal subunit Source: EcoliWiki
Other locations
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 57 | L → H: Protein is not incorporated into ribosomes. 1 Publication | 1 | |
Mutagenesisi | 88 | K → Q: Confers low-level resistance to streptomycin and a 15% decrease in the translational elongation rate. 1 Publication | 1 |
Chemistry databases
DrugBanki | DB00479, Amikacin DB06696, Arbekacin DB00452, Framycetin DB00798, Gentamicin DB04729, Gentamicin C1a DB01172, Kanamycin DB00994, Neomycin DB00955, Netilmicin DB03615, Ribostamycin DB00919, Spectinomycin DB01082, Streptomycin DB00560, Tigecycline |
DrugCentrali | P0A7S3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000146219 | 2 – 124 | 30S ribosomal protein S12Add BLAST | 123 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | 3-methylthioaspartic acid1 Publication | 1 | |
Modified residuei | 108 | N6-acetyllysine1 Publication | 1 |
Keywords - PTMi
Acetylation, MethylationProteomic databases
jPOSTi | P0A7S3 |
PaxDbi | P0A7S3 |
PRIDEi | P0A7S3 |
PTM databases
iPTMneti | P0A7S3 |
Interactioni
Subunit structurei
Part of the 30S ribosomal subunit (PubMed:320034, PubMed:7556101, PubMed:12809609, PubMed:16272117, PubMed:27934701, PubMed:10094780, PubMed:12093756, PubMed:12379845, PubMed:12244297, PubMed:27906160, PubMed:27906161). Contacts proteins S8 and S17.
Interacts with ArfA (PubMed:27906160, PubMed:27906161). May interact with IF1 in the 30S initiation complex (By similarity).
By similarity11 PublicationsBinary interactionsi
P0A7S3
With | #Exp. | IntAct |
---|---|---|
rimP [P0A8A8] | 3 | EBI-543960,EBI-561065 |
Protein-protein interaction databases
BioGRIDi | 852156, 1 interactor |
ComplexPortali | CPX-3802, 30S small ribosomal subunit |
DIPi | DIP-35806N |
IntActi | P0A7S3, 45 interactors |
STRINGi | 511145.b3342 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P0A7S3 |
SMRi | P0A7S3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A7S3 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0048, Bacteria |
HOGENOMi | CLU_104295_1_2_6 |
InParanoidi | P0A7S3 |
OMAi | SPALEKC |
PhylomeDBi | P0A7S3 |
Family and domain databases
CDDi | cd03368, Ribosomal_S12, 1 hit |
DisProti | DP00145 |
Gene3Di | 2.40.50.140, 1 hit |
HAMAPi | MF_00403_B, Ribosomal_S12_B, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR006032, Ribosomal_S12/S23 IPR005679, Ribosomal_S12_bac |
PANTHERi | PTHR11652, PTHR11652, 1 hit |
Pfami | View protein in Pfam PF00164, Ribosom_S12_S23, 1 hit |
PIRSFi | PIRSF002133, Ribosomal_S12/S23, 1 hit |
PRINTSi | PR01034, RIBOSOMALS12 |
SUPFAMi | SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00981, rpsL_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00055, RIBOSOMAL_S12, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MATVNQLVRK PRARKVAKSN VPALEACPQK RGVCTRVYTT TPKKPNSALR
60 70 80 90 100
KVCRVRLTNG FEVTSYIGGE GHNLQEHSVI LIRGGRVKDL PGVRYHTVRG
110 120
ALDCSGVKDR KQARSKYGVK RPKA
Mass spectrometryi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 43 | K → R Confers streptomycin resistance but not hyperaccurate translation. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00355 Genomic DNA Translation: CAA23648.1 U18997 Genomic DNA Translation: AAA58139.1 U00096 Genomic DNA Translation: AAC76367.1 AP009048 Genomic DNA Translation: BAE77949.1 AF312716 Genomic DNA Translation: AAG30936.1 AF312717 Genomic DNA Translation: AAG30937.1 V00354 Genomic DNA Translation: CAA23647.1 J01688 Genomic DNA Translation: AAA50988.1 |
PIRi | S13738, R3EC12 |
RefSeqi | NP_417801.1, NC_000913.3 WP_000246815.1, NZ_STEB01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC76367; AAC76367; b3342 BAE77949; BAE77949; BAE77949 |
GeneIDi | 64727495 67463992 947845 |
KEGGi | ecj:JW3304 eco:b3342 |
PATRICi | fig|1411691.4.peg.3389 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00355 Genomic DNA Translation: CAA23648.1 U18997 Genomic DNA Translation: AAA58139.1 U00096 Genomic DNA Translation: AAC76367.1 AP009048 Genomic DNA Translation: BAE77949.1 AF312716 Genomic DNA Translation: AAG30936.1 AF312717 Genomic DNA Translation: AAG30937.1 V00354 Genomic DNA Translation: CAA23647.1 J01688 Genomic DNA Translation: AAA50988.1 |
PIRi | S13738, R3EC12 |
RefSeqi | NP_417801.1, NC_000913.3 WP_000246815.1, NZ_STEB01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MJ1 | electron microscopy | 13.00 | O | 5-123 | [»] | |
1ZN1 | electron microscopy | 14.10 | L | 28-124 | [»] | |
2YKR | electron microscopy | 9.80 | L | 2-124 | [»] | |
3DEG | electron microscopy | - | D | 2-124 | [»] | |
3EP2 | electron microscopy | - | L | 2-124 | [»] | |
3EQ3 | electron microscopy | - | L | 2-124 | [»] | |
3EQ4 | electron microscopy | - | L | 2-124 | [»] | |
3IY8 | electron microscopy | 14.10 | L | 2-124 | [»] | |
3J0D | electron microscopy | 11.10 | I | 2-124 | [»] | |
3J0E | electron microscopy | 9.90 | F | 2-124 | [»] | |
3J9Y | electron microscopy | 3.90 | l | 1-124 | [»] | |
3J9Z | electron microscopy | 3.60 | SL | 2-124 | [»] | |
3JA1 | electron microscopy | 3.60 | SL | 2-124 | [»] | |
3JBU | electron microscopy | 3.64 | L | 1-124 | [»] | |
3JBV | electron microscopy | 3.32 | L | 1-124 | [»] | |
3JCD | electron microscopy | 3.70 | l | 1-124 | [»] | |
3JCE | electron microscopy | 3.20 | l | 1-124 | [»] | |
3JCJ | electron microscopy | 3.70 | t | 1-124 | [»] | |
3JCN | electron microscopy | 4.60 | o | 1-124 | [»] | |
4A2I | electron microscopy | 16.50 | L | 2-124 | [»] | |
4ADV | electron microscopy | 13.50 | L | 2-124 | [»] | |
4U1U | X-ray | 2.95 | AL/CL | 2-124 | [»] | |
4U1V | X-ray | 3.00 | AL/CL | 2-124 | [»] | |
4U20 | X-ray | 2.90 | AL/CL | 2-124 | [»] | |
4U24 | X-ray | 2.90 | AL/CL | 2-124 | [»] | |
4U25 | X-ray | 2.90 | AL/CL | 2-124 | [»] | |
4U26 | X-ray | 2.80 | AL/CL | 2-124 | [»] | |
4U27 | X-ray | 2.80 | AL/CL | 2-124 | [»] | |
4V47 | electron microscopy | 12.30 | BL | 2-124 | [»] | |
4V48 | electron microscopy | 11.50 | BL | 2-124 | [»] | |
4V4H | X-ray | 3.46 | AL/CL | 1-124 | [»] | |
4V4Q | X-ray | 3.46 | AL/CL | 2-124 | [»] | |
4V4V | electron microscopy | 15.00 | AL | 23-123 | [»] | |
4V4W | electron microscopy | 15.00 | AL | 23-123 | [»] | |
4V50 | X-ray | 3.22 | AL/CL | 2-124 | [»] | |
4V52 | X-ray | 3.21 | AL/CL | 2-124 | [»] | |
4V53 | X-ray | 3.54 | AL/CL | 2-124 | [»] | |
4V54 | X-ray | 3.30 | AL/CL | 2-124 | [»] | |
4V55 | X-ray | 4.00 | AL/CL | 2-124 | [»] | |
4V56 | X-ray | 3.93 | AL/CL | 2-124 | [»] | |
4V57 | X-ray | 3.50 | AL/CL | 2-124 | [»] | |
4V5B | X-ray | 3.74 | BL/DL | 2-124 | [»] | |
4V5H | electron microscopy | 5.80 | AL | 2-124 | [»] | |
4V5Y | X-ray | 4.45 | AL/CL | 2-124 | [»] | |
4V64 | X-ray | 3.50 | AL/CL | 2-124 | [»] | |
4V65 | electron microscopy | 9.00 | AD | 1-124 | [»] | |
4V66 | electron microscopy | 9.00 | AD | 1-124 | [»] | |
4V69 | electron microscopy | 6.70 | AL | 2-124 | [»] | |
4V6C | X-ray | 3.19 | AL/CL | 1-124 | [»] | |
4V6D | X-ray | 3.81 | AL/CL | 1-124 | [»] | |
4V6E | X-ray | 3.71 | AL/CL | 1-124 | [»] | |
4V6K | electron microscopy | 8.25 | BP | 1-124 | [»] | |
4V6L | electron microscopy | 13.20 | AP | 1-124 | [»] | |
4V6M | electron microscopy | 7.10 | AL | 2-124 | [»] | |
AO | 2-89 | [»] | ||||
4V6N | electron microscopy | 12.10 | BO | 2-124 | [»] | |
4V6O | electron microscopy | 14.70 | AO | 2-124 | [»] | |
4V6P | electron microscopy | 13.50 | AO | 2-124 | [»] | |
4V6Q | electron microscopy | 11.50 | AO | 2-124 | [»] | |
4V6R | electron microscopy | 11.50 | AO | 2-124 | [»] | |
4V6S | electron microscopy | 13.10 | BN | 2-124 | [»] | |
4V6T | electron microscopy | 8.30 | AL | 2-124 | [»] | |
4V6V | electron microscopy | 9.80 | AL | 2-124 | [»] | |
4V6Y | electron microscopy | 12.00 | AL | 1-124 | [»] | |
4V6Z | electron microscopy | 12.00 | AL | 1-124 | [»] | |
4V70 | electron microscopy | 17.00 | AL | 1-124 | [»] | |
4V71 | electron microscopy | 20.00 | AL | 1-124 | [»] | |
4V72 | electron microscopy | 13.00 | AL | 1-124 | [»] | |
4V73 | electron microscopy | 15.00 | AL | 1-124 | [»] | |
4V74 | electron microscopy | 17.00 | AL | 1-124 | [»] | |
4V75 | electron microscopy | 12.00 | AL | 1-124 | [»] | |
4V76 | electron microscopy | 17.00 | AL | 1-124 | [»] | |
4V77 | electron microscopy | 17.00 | AL | 1-124 | [»] | |
4V78 | electron microscopy | 20.00 | AL | 1-124 | [»] | |
4V79 | electron microscopy | 15.00 | AL | 1-124 | [»] | |
4V7A | electron microscopy | 9.00 | AL | 1-124 | [»] | |
4V7B | electron microscopy | 6.80 | AL | 1-124 | [»] | |
4V7C | electron microscopy | 7.60 | AL | 2-124 | [»] | |
4V7D | electron microscopy | 7.60 | BL | 2-124 | [»] | |
4V7I | electron microscopy | 9.60 | BL | 1-124 | [»] | |
4V7S | X-ray | 3.25 | AL/CL | 2-124 | [»] | |
4V7T | X-ray | 3.19 | AL/CL | 2-124 | [»] | |
4V7U | X-ray | 3.10 | AL/CL | 2-124 | [»] | |
4V7V | X-ray | 3.29 | AL/CL | 2-124 | [»] | |
4V85 | X-ray | 3.20 | AL | 1-124 | [»] | |
4V89 | X-ray | 3.70 | AL | 1-124 | [»] | |
4V9C | X-ray | 3.30 | AL/CL | 1-124 | [»] | |
4V9D | X-ray | 3.00 | AL/BL | 2-124 | [»] | |
4V9O | X-ray | 2.90 | BL/DL/FL/HL | 1-124 | [»] | |
4V9P | X-ray | 2.90 | BL/DL/FL/HL | 1-124 | [»] | |
4WF1 | X-ray | 3.09 | AL/CL | 2-124 | [»] | |
4WOI | X-ray | 3.00 | AL/DL | 1-124 | [»] | |
4WWW | X-ray | 3.10 | QL/XL | 2-124 | [»] | |
4YBB | X-ray | 2.10 | AL/BL | 2-124 | [»] | |
5AFI | electron microscopy | 2.90 | l | 1-124 | [»] | |
5H5U | electron microscopy | 3.00 | s | 2-124 | [»] | |
5IQR | electron microscopy | 3.00 | q | 1-124 | [»] | |
5IT8 | X-ray | 3.12 | AL/BL | 2-124 | [»] | |
5J5B | X-ray | 2.80 | AL/BL | 2-124 | [»] | |
5J7L | X-ray | 3.00 | AL/BL | 2-124 | [»] | |
5J88 | X-ray | 3.32 | AL/BL | 2-124 | [»] | |
5J8A | X-ray | 3.10 | AL/BL | 2-124 | [»] | |
5J91 | X-ray | 2.96 | AL/BL | 2-124 | [»] | |
5JC9 | X-ray | 3.03 | AL/BL | 2-124 | [»] | |
5JTE | electron microscopy | 3.60 | AL | 1-124 | [»] | |
5JU8 | electron microscopy | 3.60 | AL | 1-124 | [»] | |
5KCR | electron microscopy | 3.60 | 1l | 1-124 | [»] | |
5KCS | electron microscopy | 3.90 | 1l | 1-124 | [»] | |
5KPS | electron microscopy | 3.90 | 17 | 1-124 | [»] | |
5KPV | electron microscopy | 4.10 | 16 | 1-124 | [»] | |
5KPW | electron microscopy | 3.90 | 16 | 1-124 | [»] | |
5KPX | electron microscopy | 3.90 | 16 | 1-124 | [»] | |
5L3P | electron microscopy | 3.70 | l | 1-124 | [»] | |
5LZA | electron microscopy | 3.60 | l | 2-124 | [»] | |
5LZB | electron microscopy | 5.30 | l | 2-124 | [»] | |
5LZC | electron microscopy | 4.80 | l | 2-124 | [»] | |
5LZD | electron microscopy | 3.40 | l | 2-124 | [»] | |
5LZE | electron microscopy | 3.50 | l | 2-124 | [»] | |
5LZF | electron microscopy | 4.60 | l | 2-124 | [»] | |
5MDV | electron microscopy | 2.97 | q | 1-124 | [»] | |
5MDW | electron microscopy | 3.06 | q | 1-124 | [»] | |
5MDY | electron microscopy | 3.35 | q | 1-124 | [»] | |
5MDZ | electron microscopy | 3.10 | q | 1-124 | [»] | |
5ME0 | electron microscopy | 13.50 | L | 2-124 | [»] | |
5ME1 | electron microscopy | 13.50 | L | 2-124 | [»] | |
5MGP | electron microscopy | 3.10 | l | 2-124 | [»] | |
5MY1 | electron microscopy | 7.60 | L | 2-124 | [»] | |
5NO2 | electron microscopy | 5.16 | L | 2-15 | [»] | |
5NO3 | electron microscopy | 5.16 | L | 2-15 | [»] | |
5NO4 | electron microscopy | 5.16 | L | 2-15 | [»] | |
5NP6 | electron microscopy | 3.60 | O | 2-124 | [»] | |
5NWY | electron microscopy | 2.93 | B | 1-124 | [»] | |
5O2R | electron microscopy | 3.40 | l | 2-124 | [»] | |
5U4I | electron microscopy | 3.50 | l | 2-124 | [»] | |
5U4J | electron microscopy | 3.70 | l | 1-124 | [»] | |
5U9F | electron microscopy | 3.20 | L | 1-124 | [»] | |
5U9G | electron microscopy | 3.20 | L | 1-124 | [»] | |
5UYK | electron microscopy | 3.90 | L | 2-124 | [»] | |
5UYL | electron microscopy | 3.60 | L | 2-124 | [»] | |
5UYM | electron microscopy | 3.20 | L | 2-124 | [»] | |
5UYN | electron microscopy | 4.00 | L | 2-124 | [»] | |
5UYP | electron microscopy | 3.90 | L | 2-124 | [»] | |
5UYQ | electron microscopy | 3.80 | L | 2-124 | [»] | |
5WDT | electron microscopy | 3.00 | l | 2-122 | [»] | |
5WE4 | electron microscopy | 3.10 | l | 2-122 | [»] | |
5WE6 | electron microscopy | 3.40 | l | 2-122 | [»] | |
5WFK | electron microscopy | 3.40 | l | 2-122 | [»] | |
6BU8 | electron microscopy | 3.50 | L | 2-124 | [»] | |
6BY1 | X-ray | 3.94 | AL/BL | 2-124 | [»] | |
6C4I | electron microscopy | 3.24 | l | 1-124 | [»] | |
6ENF | electron microscopy | 3.20 | l | 2-124 | [»] | |
6ENJ | electron microscopy | 3.70 | l | 2-124 | [»] | |
6ENU | electron microscopy | 3.10 | l | 2-124 | [»] | |
6GWT | electron microscopy | 3.80 | l | 2-124 | [»] | |
6GXM | electron microscopy | 3.80 | l | 2-124 | [»] | |
6GXN | electron microscopy | 3.90 | l | 2-124 | [»] | |
6GXO | electron microscopy | 3.90 | l | 2-124 | [»] | |
6GXP | electron microscopy | 4.40 | l | 2-124 | [»] | |
6H4N | electron microscopy | 3.00 | l | 2-124 | [»] | |
6H58 | electron microscopy | 7.90 | l/ll | 2-124 | [»] | |
6HRM | electron microscopy | 2.96 | q | 2-124 | [»] | |
6I7V | X-ray | 2.90 | AL/BL | 2-124 | [»] | |
6O9J | electron microscopy | 3.90 | l | 2-124 | [»] | |
6O9K | electron microscopy | 4.00 | l | 2-124 | [»] | |
6OFX | electron microscopy | 3.30 | Q | 2-124 | [»] | |
6OG7 | electron microscopy | 3.30 | Q | 2-124 | [»] | |
6ORE | electron microscopy | 2.90 | q | 2-124 | [»] | |
6ORL | electron microscopy | 3.50 | q | 2-124 | [»] | |
6OST | electron microscopy | 4.20 | q | 2-124 | [»] | |
6OT3 | electron microscopy | 3.90 | q | 2-88 | [»] | |
6OUO | electron microscopy | 3.70 | q | 2-88 | [»] | |
6Q9A | electron microscopy | 3.70 | q | 2-123 | [»] | |
6SZS | electron microscopy | 3.06 | l | 1-124 | [»] | |
6TBV | electron microscopy | 2.70 | S121 | 1-124 | [»] | |
6TC3 | electron microscopy | 2.70 | S121 | 1-124 | [»] | |
6VWL | electron microscopy | 3.10 | k | 1-124 | [»] | |
6VWM | electron microscopy | 3.40 | k | 1-124 | [»] | |
6VWN | electron microscopy | 3.40 | k | 1-124 | [»] | |
6W6K | electron microscopy | 3.60 | L | 1-124 | [»] | |
6W77 | electron microscopy | 3.60 | L | 1-124 | [»] | |
6W7M | electron microscopy | 3.80 | L | 1-124 | [»] | |
6W7N | electron microscopy | 3.40 | L | 1-124 | [»] | |
6W7W | electron microscopy | 3.90 | K | 1-124 | [»] | |
6WD6 | electron microscopy | 3.70 | Q | 2-124 | [»] | |
6WDB | electron microscopy | 4.00 | Q | 2-124 | [»] | |
6WDC | electron microscopy | 4.20 | Q | 2-124 | [»] | |
6WDD | electron microscopy | 3.20 | Q | 2-124 | [»] | |
6WDE | electron microscopy | 3.00 | Q | 2-124 | [»] | |
6WDF | electron microscopy | 3.30 | Q | 2-124 | [»] | |
6WDG | electron microscopy | 3.30 | Q | 2-124 | [»] | |
6WDH | electron microscopy | 4.30 | Q | 2-124 | [»] | |
6WDI | electron microscopy | 4.00 | Q | 2-124 | [»] | |
6WDJ | electron microscopy | 3.70 | Q | 2-124 | [»] | |
6WDK | electron microscopy | 3.60 | Q | 2-124 | [»] | |
6WDL | electron microscopy | 3.70 | Q | 2-124 | [»] | |
6WDM | electron microscopy | 3.60 | Q | 2-124 | [»] | |
6WNV | electron microscopy | 3.50 | Q | 2-124 | [»] | |
6WNW | electron microscopy | 3.20 | Q | 2-124 | [»] | |
6XE0 | electron microscopy | 6.80 | K | 2-124 | [»] | |
6XZA | electron microscopy | 2.66 | L1 | 2-124 | [»] | |
6XZB | electron microscopy | 2.54 | L1 | 2-124 | [»] | |
6Y69 | electron microscopy | 2.86 | l | 2-124 | [»] | |
6ZTL | electron microscopy | 3.50 | AL | 1-124 | [»] | |
7ABZ | electron microscopy | 3.21 | q | 2-124 | [»] | |
7AC7 | electron microscopy | 3.08 | q | 2-124 | [»] | |
7ACJ | electron microscopy | 3.20 | q | 2-123 | [»] | |
7ACR | electron microscopy | 3.44 | q | 2-123 | [»] | |
7B5K | electron microscopy | 2.90 | l | 2-124 | [»] | |
7BOD | electron microscopy | 2.88 | L | 1-124 | [»] | |
7BOE | electron microscopy | 2.90 | L | 1-124 | [»] | |
7BOF | electron microscopy | 2.92 | L | 1-124 | [»] | |
7BOG | electron microscopy | 2.75 | L | 1-124 | [»] | |
7BOH | electron microscopy | 2.82 | L | 1-124 | [»] | |
7BOI | electron microscopy | 2.98 | L | 1-124 | [»] | |
7D6Z | electron microscopy | 3.40 | s | 1-124 | [»] | |
7D80 | electron microscopy | 4.10 | M | 1-124 | [»] | |
7JSS | electron microscopy | 3.70 | Q | 2-124 | [»] | |
7JSW | electron microscopy | 3.80 | Q | 2-124 | [»] | |
7JSZ | electron microscopy | 3.70 | Q | 2-124 | [»] | |
7JT1 | electron microscopy | 3.30 | Q | 2-124 | [»] | |
7JT2 | electron microscopy | 3.50 | Q | 2-124 | [»] | |
7JT3 | electron microscopy | 3.70 | Q | 2-124 | [»] | |
7K50 | electron microscopy | 3.40 | Q | 2-124 | [»] | |
7K51 | electron microscopy | 3.50 | Q | 2-124 | [»] | |
7K52 | electron microscopy | 3.40 | Q | 2-124 | [»] | |
7K53 | electron microscopy | 3.20 | Q | 2-124 | [»] | |
7K54 | electron microscopy | 3.20 | Q | 2-124 | [»] | |
7K55 | electron microscopy | 3.30 | Q | 2-124 | [»] | |
7LV0 | electron microscopy | 3.20 | Q | 2-124 | [»] | |
7NAR | electron microscopy | 3.00 | L | 1-124 | [»] | |
7NAS | electron microscopy | 3.31 | L | 1-124 | [»] | |
7NAT | electron microscopy | 3.59 | L | 1-124 | [»] | |
7NAU | electron microscopy | 3.78 | L | 1-124 | [»] | |
7NAV | electron microscopy | 4.80 | L | 1-124 | [»] | |
7NWT | electron microscopy | 2.66 | q | 1-124 | [»] | |
7O19 | electron microscopy | 2.90 | AL | 1-124 | [»] | |
7O1A | electron microscopy | 2.40 | AL | 1-124 | [»] | |
7O1C | electron microscopy | 2.60 | AL | 1-124 | [»] | |
7O5H | electron microscopy | 3.10 | L | 2-124 | [»] | |
7OE0 | electron microscopy | 2.69 | L | 2-124 | [»] | |
7OE1 | electron microscopy | 3.05 | L | 2-124 | [»] | |
7OI0 | electron microscopy | 2.76 | L | 2-124 | [»] | |
7OIZ | electron microscopy | 2.90 | L | 1-124 | [»] | |
7OJ0 | electron microscopy | 3.50 | L | 1-124 | [»] | |
7P3K | electron microscopy | 2.90 | L | 1-124 | [»] | |
7PJV | electron microscopy | 3.10 | l | 1-124 | [»] | |
7PJY | electron microscopy | 3.10 | l | 1-124 | [»] | |
7S1K | electron microscopy | 2.42 | t | 1-124 | [»] | |
AlphaFoldDBi | P0A7S3 | |||||
SMRi | P0A7S3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 852156, 1 interactor |
ComplexPortali | CPX-3802, 30S small ribosomal subunit |
DIPi | DIP-35806N |
IntActi | P0A7S3, 45 interactors |
STRINGi | 511145.b3342 |
Chemistry databases
DrugBanki | DB00479, Amikacin DB06696, Arbekacin DB00452, Framycetin DB00798, Gentamicin DB04729, Gentamicin C1a DB01172, Kanamycin DB00994, Neomycin DB00955, Netilmicin DB03615, Ribostamycin DB00919, Spectinomycin DB01082, Streptomycin DB00560, Tigecycline |
DrugCentrali | P0A7S3 |
PTM databases
iPTMneti | P0A7S3 |
Proteomic databases
jPOSTi | P0A7S3 |
PaxDbi | P0A7S3 |
PRIDEi | P0A7S3 |
Genome annotation databases
EnsemblBacteriai | AAC76367; AAC76367; b3342 BAE77949; BAE77949; BAE77949 |
GeneIDi | 64727495 67463992 947845 |
KEGGi | ecj:JW3304 eco:b3342 |
PATRICi | fig|1411691.4.peg.3389 |
Organism-specific databases
EchoBASEi | EB0904 |
Phylogenomic databases
eggNOGi | COG0048, Bacteria |
HOGENOMi | CLU_104295_1_2_6 |
InParanoidi | P0A7S3 |
OMAi | SPALEKC |
PhylomeDBi | P0A7S3 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10911-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A7S3 |
PROi | PR:P0A7S3 |
Family and domain databases
CDDi | cd03368, Ribosomal_S12, 1 hit |
DisProti | DP00145 |
Gene3Di | 2.40.50.140, 1 hit |
HAMAPi | MF_00403_B, Ribosomal_S12_B, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR006032, Ribosomal_S12/S23 IPR005679, Ribosomal_S12_bac |
PANTHERi | PTHR11652, PTHR11652, 1 hit |
Pfami | View protein in Pfam PF00164, Ribosom_S12_S23, 1 hit |
PIRSFi | PIRSF002133, Ribosomal_S12/S23, 1 hit |
PRINTSi | PR01034, RIBOSOMALS12 |
SUPFAMi | SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00981, rpsL_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00055, RIBOSOMAL_S12, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RS12_ECOLI | |
Accessioni | P0A7S3Primary (citable) accession number: P0A7S3 Secondary accession number(s): P02367, Q2M707, Q9F5N3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families