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Protein

50S ribosomal protein L29

Gene

rpmC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds 23S rRNA. It is not essential for growth.2 Publications
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (PubMed:12226666).1 Publication

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10887-MONOMER
MetaCyc:EG10887-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L29
Alternative name(s):
Large ribosomal subunit protein uL291 Publication
Gene namesi
Name:rpmC
Ordered Locus Names:b3312, JW3274
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10887 rpmC

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Cells missing both S17 and L29 grow very slowly and have a rather unstable temperature-sensitive phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001303841 – 6350S ribosomal protein L29Add BLAST63

Proteomic databases

EPDiP0A7M6
PaxDbiP0A7M6
PRIDEiP0A7M6

Interactioni

Subunit structurei

Part of the 50s ribosomal subunit (PubMed:1092361, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:21499241, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Contacts protein L23 (PubMed:2665813), trigger factor (PubMed:12226666) and protein nascent chains (PubMed:12756233). Might also contact SecE and probably does contact SecG when the SecYEG translocation complex is docked with the ribosome (PubMed:16292303).1 Publication13 Publications

Protein-protein interaction databases

DIPiDIP-47911N
IntActiP0A7M6, 35 interactors
STRINGi316385.ECDH10B_3487

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A7M6
SMRiP0A7M6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A7M6

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41083MP Bacteria
COG0255 LUCA
HOGENOMiHOG000248754
InParanoidiP0A7M6
KOiK02904
OMAiRFQNATN
PhylomeDBiP0A7M6

Family and domain databases

HAMAPiMF_00374 Ribosomal_L29, 1 hit
InterProiView protein in InterPro
IPR001854 Ribosomal_L29/L35
IPR036049 Ribosomal_L29/L35_sf
IPR018254 Ribosomal_L29_CS
PfamiView protein in Pfam
PF00831 Ribosomal_L29, 1 hit
SUPFAMiSSF46561 SSF46561, 1 hit
TIGRFAMsiTIGR00012 L29, 1 hit
PROSITEiView protein in PROSITE
PS00579 RIBOSOMAL_L29, 1 hit

Sequencei

Sequence statusi: Complete.

P0A7M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKELREKS VEELNTELLN LLREQFNLRM QAASGQLQQS HLLKQVRRDV
60
ARVKTLLNEK AGA
Length:63
Mass (Da):7,273
Last modified:April 1, 1988 - v1
Checksum:iDAEF8F126B0AA077
GO

Sequence cautioni

The sequence described in PubMed:1092361 differs from that shown. Exchange of two tryptic peptides.Curated

Mass spectrometryi

Molecular mass is 7273.4 Da from positions 1 - 63. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02613 Genomic DNA Translation: CAA26468.1
U18997 Genomic DNA Translation: AAA58109.1
U00096 Genomic DNA Translation: AAC76337.1
AP009048 Genomic DNA Translation: BAE77979.1
PIRiB37519 R5EC29
RefSeqiNP_417771.1, NC_000913.3
WP_000644741.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76337; AAC76337; b3312
BAE77979; BAE77979; BAE77979
GeneIDi947807
KEGGiecj:JW3274
eco:b3312
PATRICifig|1411691.4.peg.3419

Similar proteinsi

Entry informationi

Entry nameiRL29_ECOLI
AccessioniPrimary (citable) accession number: P0A7M6
Secondary accession number(s): P02429, Q2M6X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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