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Protein

50S ribosomal protein L11

Gene

rplK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.

GO - Molecular functioni

  • rRNA binding Source: EcoCyc
  • structural constituent of ribosome Source: CAFA

GO - Biological processi

  • ribosomal large subunit assembly Source: CAFA
  • stringent response Source: EcoCyc
  • translational termination Source: EcoCyc

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10872-MONOMER
MetaCyc:EG10872-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L11UniRule annotation
Alternative name(s):
Large ribosomal subunit protein uL111 Publication
Gene namesi
Name:rplKUniRule annotation
Synonyms:relC
Ordered Locus Names:b3983, JW3946
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10872 rplK

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • cytosolic large ribosomal subunit Source: CAFA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001042832 – 14250S ribosomal protein L11Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine1 Publication1
Modified residuei4N6,N6,N6-trimethyllysine1 Publication1
Modified residuei40N6,N6,N6-trimethyllysine1 Publication1
Modified residuei72N6-succinyllysine1 Publication1
Modified residuei81N6-succinyllysine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

EPDiP0A7J7
PaxDbiP0A7J7
PRIDEiP0A7J7

PTM databases

iPTMnetiP0A7J7

Interactioni

Subunit structurei

Part of the ribosomal stalk of the 50S ribosomal subunit (PubMed:15923259). Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 2 L12 dimers bind in a sequential fashion forming a pentameric L10(L12)2(L12)2 complex (PubMed:15923259).11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
prmAP0A8T14EBI-547288,EBI-556300

Protein-protein interaction databases

BioGridi852778, 1 interactor
DIPiDIP-35882N
IntActiP0A7J7, 49 interactors
STRINGi316385.ECDH10B_4171

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi76 – 83Combined sources8
Turni93 – 95Combined sources3
Helixi103 – 116Combined sources14
Helixi122 – 135Combined sources14

3D structure databases

ProteinModelPortaliP0A7J7
SMRiP0A7J7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A7J7

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL11 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0080 LUCA
HOGENOMiHOG000082123
InParanoidiP0A7J7
KOiK02867
OMAiCKQFNAK
PhylomeDBiP0A7J7

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR006519 Ribosomal_L11_bac-typ
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020785 Ribosomal_L11_CS
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
TIGRFAMsiTIGR01632 L11_bact, 1 hit
PROSITEiView protein in PROSITE
PS00359 RIBOSOMAL_L11, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A7J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVQAYVK LQVAAGMANP SPPVGPALGQ QGVNIMEFCK AFNAKTDSIE
60 70 80 90 100
KGLPIPVVIT VYADRSFTFV TKTPPAAVLL KKAAGIKSGS GKPNKDKVGK
110 120 130 140
ISRAQLQEIA QTKAADMTGA DIEAMTRSIE GTARSMGLVV ED
Length:142
Mass (Da):14,875
Last modified:January 23, 2007 - v2
Checksum:iC49226BB2462BE0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132T → S in CAA23621 (PubMed:377281).Curated1

Mass spectrometryi

Molecular mass is 14870.2 Da from positions 2 - 142. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00339 Genomic DNA Translation: CAA23621.1
M30610 Genomic DNA Translation: AAA24623.1
U00006 Genomic DNA Translation: AAC43081.1
U00096 Genomic DNA Translation: AAC76957.1
AP009048 Genomic DNA Translation: BAE77337.1
PIRiS12572 R5EC11
RefSeqiNP_418410.1, NC_000913.3
WP_001085926.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76957; AAC76957; b3983
BAE77337; BAE77337; BAE77337
GeneIDi948484
KEGGiecj:JW3946
eco:b3983
PATRICifig|1411691.4.peg.2729

Similar proteinsi

Entry informationi

Entry nameiRL11_ECOLI
AccessioniPrimary (citable) accession number: P0A7J7
Secondary accession number(s): P02409, P76778, Q2M8R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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