UniProtKB - P0A7J6 (RL10_SHIFL)
Protein
50S ribosomal protein L10
Gene
rplJ
Organism
Shigella flexneri
Status
Functioni
Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA (By similarity).By similarity
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.By similarity
Miscellaneous
Ribosomal protein L8 appears to be an aggregate of ribosomal proteins L7/L12 and L10.By similarity
GO - Molecular functioni
- large ribosomal subunit rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- regulation of translation Source: UniProtKB-KW
- ribosome biogenesis Source: InterPro
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Repressor, Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Biological process | Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L10 |
Gene namesi | Name:rplJ Ordered Locus Names:SF4058, S3677 |
Organismi | Shigella flexneri |
Taxonomic identifieri | 623 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
DrugBanki | DB01211, Clarithromycin DB01627, Lincomycin DB01369, Quinupristin DB00778, Roxithromycin |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000154704 | 2 – 165 | 50S ribosomal protein L10Add BLAST | 164 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 37 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 105 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PRIDEi | P0A7J6 |
Interactioni
Subunit structurei
Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity).
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL10 family.Curated
Phylogenomic databases
HOGENOMi | CLU_092227_0_2_6 |
OMAi | VVVAHYS |
OrthoDBi | 1470978at2 |
Family and domain databases
CDDi | cd05797, Ribosomal_L10, 1 hit |
Gene3Di | 3.30.70.1730, 1 hit |
HAMAPi | MF_00362, Ribosomal_L10, 1 hit |
InterProi | View protein in InterPro IPR022973, Ribosomal_L10 IPR043141, Ribosomal_L10-like_sf IPR002363, Ribosomal_L10_eubac_CS IPR001790, Ribosomal_L10P |
PANTHERi | PTHR11560, PTHR11560, 1 hit |
Pfami | View protein in Pfam PF00466, Ribosomal_L10, 1 hit |
SUPFAMi | SSF160369, SSF160369, 1 hit |
PROSITEi | View protein in PROSITE PS01109, RIBOSOMAL_L10, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A7J6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALNLQDKQA IVAEVSEVAK GALSAVVADS RGVTVDKMTE LRKAGREAGV
60 70 80 90 100
YMRVVRNTLL RRAVEGTPFE CLKDAFVGPT LIAYSMEHPG AAARLFKEFA
110 120 130 140 150
KANAKFEVKA AAFEGELIPA SQIDRLATLP TYEEAIARLM ATMKEASAGK
160
LVRTLAAVRD AKEAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN45487.1 AE014073 Genomic DNA Translation: AAP18714.1 |
RefSeqi | NP_709780.1, NC_004337.2 WP_001207201.1, NZ_WPGW01000040.1 |
Genome annotation databases
EnsemblBacteriai | AAN45487; AAN45487; SF4058 AAP18714; AAP18714; S3677 |
GeneIDi | 1025180 58462387 |
KEGGi | sfl:SF4058 sfx:S3677 |
PATRICi | fig|198214.7.peg.4781 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN45487.1 AE014073 Genomic DNA Translation: AAP18714.1 |
RefSeqi | NP_709780.1, NC_004337.2 WP_001207201.1, NZ_WPGW01000040.1 |
3D structure databases
SMRi | P0A7J6 |
ModBasei | Search... |
Chemistry databases
DrugBanki | DB01211, Clarithromycin DB01627, Lincomycin DB01369, Quinupristin DB00778, Roxithromycin |
Proteomic databases
PRIDEi | P0A7J6 |
Genome annotation databases
EnsemblBacteriai | AAN45487; AAN45487; SF4058 AAP18714; AAP18714; S3677 |
GeneIDi | 1025180 58462387 |
KEGGi | sfl:SF4058 sfx:S3677 |
PATRICi | fig|198214.7.peg.4781 |
Phylogenomic databases
HOGENOMi | CLU_092227_0_2_6 |
OMAi | VVVAHYS |
OrthoDBi | 1470978at2 |
Family and domain databases
CDDi | cd05797, Ribosomal_L10, 1 hit |
Gene3Di | 3.30.70.1730, 1 hit |
HAMAPi | MF_00362, Ribosomal_L10, 1 hit |
InterProi | View protein in InterPro IPR022973, Ribosomal_L10 IPR043141, Ribosomal_L10-like_sf IPR002363, Ribosomal_L10_eubac_CS IPR001790, Ribosomal_L10P |
PANTHERi | PTHR11560, PTHR11560, 1 hit |
Pfami | View protein in Pfam PF00466, Ribosomal_L10, 1 hit |
SUPFAMi | SSF160369, SSF160369, 1 hit |
PROSITEi | View protein in PROSITE PS01109, RIBOSOMAL_L10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL10_SHIFL | |
Accessioni | P0A7J6Primary (citable) accession number: P0A7J6 Secondary accession number(s): P02408 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families