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UniProtKB - P0A7F3 (PYRI_ECOLI)

Entry version 148 (23 Feb 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Aspartate carbamoyltransferase regulatory chain

Gene

pyrI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in allosteric regulation of aspartate carbamoyltransferase.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109Zinc1
Metal bindingi114Zinc1
Metal bindingi138Zinc1
Metal bindingi141Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPyrimidine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:ASPCARBREG-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aspartate carbamoyltransferase regulatory chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pyrI
Ordered Locus Names:b4244, JW4203
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001423032 – 153Aspartate carbamoyltransferase regulatory chainAdd BLAST152

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0A7F3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0A7F3

PRoteomics IDEntifications database

More...PRIDEi		P0A7F3

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P0A7F3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263117, 11 interactors
853052, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3091, Aspartate carbamoyltransferase complex

Database of interacting proteins

More...DIPi		DIP-35088N

Protein interaction database and analysis system

More...IntActi		P0A7F3, 2 interactors

Molecular INTeraction database

More...MINTi		P0A7F3

STRING: functional protein association networks

More...STRINGi		511145.b4244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0A7F3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P0A7F3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PyrI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1781, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_128576_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0A7F3

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0A7F3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.140, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00002, Asp_carb_tr_reg, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020545, Asp_carbamoyltransf_reg_N
IPR002801, Asp_carbamoylTrfase_reg
IPR020542, Asp_carbamoyltrfase_reg_C
IPR036792, Asp_carbatrfase_reg_C_sf
IPR036793, Asp_carbatrfase_reg_N_sf

The PANTHER Classification System

More...PANTHERi		PTHR35805, PTHR35805, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01948, PyrI, 1 hit
PF02748, PyrI_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54893, SSF54893, 1 hit
SSF57825, SSF57825, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00240, ATCase_reg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0A7F3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHDNKLQVE AIKRGTVIDH IPAQIGFKLL SLFKLTETDQ RITIGLNLPS 
        60         70         80         90        100
GEMGRKDLIK IENTFLSEDQ VDQLALYAPQ ATVNRIDNYE VVGKSRPSLP 
       110        120        130        140        150
ERIDNVLVCP NSNCISHAEP VSSSFAVRKR ANDIALKCKY CEKEFSHNVV 

LAN
Length:153
Mass (Da):17,121
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81A1631614E549EA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
K01472 Genomic DNA Translation: AAA24477.1
U14003 Genomic DNA Translation: AAA97141.1
U00096 Genomic DNA Translation: AAC77201.1
AP009048 Genomic DNA Translation: BAE78243.1
M28578 Genomic DNA Translation: AAA24487.1

Protein sequence database of the Protein Information Resource

More...PIRi		A93985, DTECR

NCBI Reference Sequences

More...RefSeqi		NP_418665.1, NC_000913.3
WP_000148581.1, NZ_STEB01000013.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77201; AAC77201; b4244
BAE78243; BAE78243; BAE78243

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67414869
948763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4203
eco:b4244

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2457

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01472 Genomic DNA Translation: AAA24477.1
U14003 Genomic DNA Translation: AAA97141.1
U00096 Genomic DNA Translation: AAC77201.1
AP009048 Genomic DNA Translation: BAE78243.1
M28578 Genomic DNA Translation: AAA24487.1
PIRiA93985, DTECR
RefSeqiNP_418665.1, NC_000913.3
WP_000148581.1, NZ_STEB01000013.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ACMX-ray2.80B/D1-153[»]
1AT1X-ray2.80B/D1-153[»]
1D09X-ray2.10B/D1-153[»]
1EZZX-ray2.70B/D1-153[»]
1F1BX-ray2.30B/D1-153[»]
1I5OX-ray2.80B/D1-153[»]
1NBEX-ray2.60B/D1-153[»]
1Q95X-ray2.46G/H/I/J/K/L1-153[»]
1R0BX-ray2.90G/H/I/J/K/L1-153[»]
1R0CX-ray2.37B/H1-153[»]
1RAAX-ray2.50B/D1-153[»]
1RABX-ray2.50B/D1-153[»]
1RACX-ray2.50B/D1-153[»]
1RADX-ray2.50B/D1-153[»]
1RAEX-ray2.50B/D1-153[»]
1RAFX-ray2.50B/D1-153[»]
1RAGX-ray2.50B/D1-153[»]
1RAHX-ray2.50B/D1-153[»]
1RAIX-ray2.50B/D1-153[»]
1SKUX-ray2.60B/D1-153[»]
1TTHX-ray2.80B/D1-153[»]
1TU0X-ray2.55B/D1-153[»]
1TUGX-ray2.10B/D1-153[»]
1XJWX-ray2.71B/D1-153[»]
1ZA1X-ray2.20B/D1-153[»]
1ZA2X-ray2.50B/D1-153[»]
2A0FX-ray2.90B/D1-153[»]
2AIRX-ray2.00B/H1-153[»]
2AT1X-ray2.80B/D1-153[»]
2ATCX-ray3.00B1-153[»]
2FZCX-ray2.10B/D1-153[»]
2FZGX-ray2.25B/D1-153[»]
2FZKX-ray2.50B/D1-153[»]
2H3EX-ray2.30B/D1-153[»]
2HSEX-ray2.60B/D1-153[»]
2IPOX-ray2.60B/D1-153[»]
2QG9X-ray2.70B/D1-153[»]
2QGFX-ray2.20B/D1-153[»]
3AT1X-ray2.80B/D1-153[»]
3D7SX-ray2.80B/D1-153[»]
3MPUX-ray2.86B/D/F1-153[»]
4AT1X-ray2.60B/D1-153[»]
4E2FX-ray2.80B/D/F/H/J/L1-153[»]
4F04X-ray2.30B/D1-153[»]
4FYVX-ray2.10B/D1-153[»]
4FYWX-ray2.10B/D1-153[»]
4FYXX-ray2.09B/D1-153[»]
4FYYX-ray1.94B/D1-153[»]
5AT1X-ray2.60B/D1-153[»]
6AT1X-ray2.60B/D1-153[»]
6KJ8X-ray3.01B/D/F1-153[»]
6KJAX-ray3.06B/D/F1-153[»]
6KJBX-ray2.06B1-153[»]
7AT1X-ray2.80B/D1-153[»]
8AT1X-ray2.80B/D1-153[»]
8ATCX-ray2.50B/D1-153[»]
9ATCX-ray2.40B8-153[»]
SMRiP0A7F3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4263117, 11 interactors
853052, 1 interactor
ComplexPortaliCPX-3091, Aspartate carbamoyltransferase complex
DIPiDIP-35088N
IntActiP0A7F3, 2 interactors
MINTiP0A7F3
STRINGi511145.b4244

2D gel databases

SWISS-2DPAGEiP0A7F3

Proteomic databases

jPOSTiP0A7F3
PaxDbiP0A7F3
PRIDEiP0A7F3

Genome annotation databases

EnsemblBacteriaiAAC77201; AAC77201; b4244
BAE78243; BAE78243; BAE78243
GeneIDi67414869
948763
KEGGiecj:JW4203
eco:b4244
PATRICifig|1411691.4.peg.2457

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0804

Phylogenomic databases

eggNOGiCOG1781, Bacteria
HOGENOMiCLU_128576_0_0_6
InParanoidiP0A7F3
PhylomeDBiP0A7F3

Enzyme and pathway databases

BioCyciEcoCyc:ASPCARBREG-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A7F3

Protein Ontology

More...PROi		PR:P0A7F3

Family and domain databases

Gene3Di3.30.70.140, 1 hit
HAMAPiMF_00002, Asp_carb_tr_reg, 1 hit
InterProiView protein in InterPro
IPR020545, Asp_carbamoyltransf_reg_N
IPR002801, Asp_carbamoylTrfase_reg
IPR020542, Asp_carbamoyltrfase_reg_C
IPR036792, Asp_carbatrfase_reg_C_sf
IPR036793, Asp_carbatrfase_reg_N_sf
PANTHERiPTHR35805, PTHR35805, 1 hit
PfamiView protein in Pfam
PF01948, PyrI, 1 hit
PF02748, PyrI_C, 1 hit
SUPFAMiSSF54893, SSF54893, 1 hit
SSF57825, SSF57825, 1 hit
TIGRFAMsiTIGR00240, ATCase_reg, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYRI_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A7F3
Secondary accession number(s): P00478, Q2M663
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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