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Protein

Probable phosphoglycerate mutase GpmB

Gene

gpmB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase A (gapA)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), Probable phosphoglycerate mutase GpmB (gpmB)
  4. Enolase (eno)
  5. Pyruvate kinase I (pykF), Pyruvate kinase II (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotationBy similarity1
Binding sitei58SubstrateUniRule annotationBy similarity1
Binding sitei60SubstrateUniRule annotationBy similarity1
Active sitei82Proton donor/acceptorUniRule annotationBy similarity1
Sitei150Transition state stabilizerUniRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis

Enzyme and pathway databases

BioCyciEcoCyc:PGAM2-MONOMER
UniPathwayi
UPA00109;UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglycerate mutase GpmBUniRule annotation (EC:5.4.2.-UniRule annotation)
Alternative name(s):
PGAMUniRule annotation
PhosphoglyceromutaseUniRule annotation
Gene namesi
Name:gpmBUniRule annotation
Synonyms:ytjC
Ordered Locus Names:b4395, JW4358
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12164 gpmB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001799461 – 215Probable phosphoglycerate mutase GpmBAdd BLAST215

Proteomic databases

EPDiP0A7A2
PaxDbiP0A7A2
PRIDEiP0A7A2

Interactioni

Protein-protein interaction databases

BioGridi4261680, 6 interactors
DIPiDIP-9829N
IntActiP0A7A2, 5 interactors
STRINGi316385.ECDH10B_4553

Structurei

3D structure databases

ProteinModelPortaliP0A7A2
SMRiP0A7A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotationBy similarity8
Regioni21 – 22Substrate bindingUniRule annotationBy similarity2
Regioni82 – 85Substrate bindingUniRule annotationBy similarity4
Regioni104 – 105Substrate bindingUniRule annotationBy similarity2
Regioni151 – 152Substrate bindingUniRule annotationBy similarity2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. GpmB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CVJ Bacteria
COG0406 LUCA
HOGENOMiHOG000221683
InParanoidiP0A7A2
KOiK15634
PhylomeDBiP0A7A2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01040 PGAM_GpmB, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR023086 Phosphoglycerate_mutase_GpmB
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A7A2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQVYLVRHG ETQWNAERRI QGQSDSPLTA KGEQQAMQVA TRAKELGITH
60 70 80 90 100
IISSDLGRTR RTAEIIAQAC GCDIIFDSRL RELNMGVLEK RHIDSLTEEE
110 120 130 140 150
ENWRRQLVNG TVDGRIPEGE SMQELSDRVN AALESCRDLP QGSRPLLVSH
160 170 180 190 200
GIALGCLVST ILGLPAWAER RLRLRNCSIS RVDYQESLWL ASGWVVETAG
210
DISHLDAPAL DELQR
Length:215
Mass (Da):24,065
Last modified:June 7, 2005 - v1
Checksum:i3653DA0548B9E009
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148V → L (PubMed:8449900).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97495 Genomic DNA No translation available.
U14003 Genomic DNA Translation: AAA97291.1
U00096 Genomic DNA Translation: AAC77348.1
AP009048 Genomic DNA Translation: BAE78384.1
PIRiS56619
RefSeqiNP_418812.1, NC_000913.3
WP_000942344.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77348; AAC77348; b4395
BAE78384; BAE78384; BAE78384
GeneIDi948918
KEGGiecj:JW4358
eco:b4395
PATRICifig|1411691.4.peg.2289

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97495 Genomic DNA No translation available.
U14003 Genomic DNA Translation: AAA97291.1
U00096 Genomic DNA Translation: AAC77348.1
AP009048 Genomic DNA Translation: BAE78384.1
PIRiS56619
RefSeqiNP_418812.1, NC_000913.3
WP_000942344.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0A7A2
SMRiP0A7A2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261680, 6 interactors
DIPiDIP-9829N
IntActiP0A7A2, 5 interactors
STRINGi316385.ECDH10B_4553

Proteomic databases

EPDiP0A7A2
PaxDbiP0A7A2
PRIDEiP0A7A2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77348; AAC77348; b4395
BAE78384; BAE78384; BAE78384
GeneIDi948918
KEGGiecj:JW4358
eco:b4395
PATRICifig|1411691.4.peg.2289

Organism-specific databases

EchoBASEiEB2083
EcoGeneiEG12164 gpmB

Phylogenomic databases

eggNOGiENOG4105CVJ Bacteria
COG0406 LUCA
HOGENOMiHOG000221683
InParanoidiP0A7A2
KOiK15634
PhylomeDBiP0A7A2

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00186

BioCyciEcoCyc:PGAM2-MONOMER

Miscellaneous databases

PROiPR:P0A7A2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01040 PGAM_GpmB, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR023086 Phosphoglycerate_mutase_GpmB
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPMB_ECOLI
AccessioniPrimary (citable) accession number: P0A7A2
Secondary accession number(s): P36942, Q2M5S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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