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Entry version 116 (13 Nov 2019)
Sequence version 1 (07 Jun 2005)
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Protein

Divalent metal cation transporter MntH

Gene

mntH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

H+-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen.UniRule annotation2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Symport, Transport
LigandIron, Manganese

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YFEP-MONOMER
ECOL316407:JW2388-MONOMER
MetaCyc:YFEP-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.55.3.1 the metal ion (mn(2+)-iron) transporter (nramp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Divalent metal cation transporter MntHUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mntHUniRule annotation
Synonyms:yfeP
Ordered Locus Names:b2392, JW2388
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19CytoplasmicUniRule annotationAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 39HelicalUniRule annotationAdd BLAST20
Topological domaini40 – 51PeriplasmicUniRule annotationAdd BLAST12
Transmembranei52 – 71HelicalUniRule annotationAdd BLAST20
Topological domaini72 – 95CytoplasmicUniRule annotationAdd BLAST24
Transmembranei96 – 118HelicalUniRule annotationAdd BLAST23
Topological domaini119 – 125PeriplasmicUniRule annotation7
Transmembranei126 – 145HelicalUniRule annotationAdd BLAST20
Topological domaini146 – 155CytoplasmicUniRule annotation10
Transmembranei156 – 175HelicalUniRule annotationAdd BLAST20
Topological domaini176 – 196PeriplasmicUniRule annotationAdd BLAST21
Transmembranei197 – 220HelicalUniRule annotationAdd BLAST24
Topological domaini221 – 238CytoplasmicUniRule annotationAdd BLAST18
Transmembranei239 – 258HelicalUniRule annotationAdd BLAST20
Topological domaini259 – 276PeriplasmicUniRule annotationAdd BLAST18
Transmembranei277 – 297HelicalUniRule annotationAdd BLAST21
Topological domaini298 – 327CytoplasmicUniRule annotationAdd BLAST30
Transmembranei328 – 344HelicalUniRule annotationAdd BLAST17
Topological domaini345 – 350PeriplasmicUniRule annotation6
Transmembranei351 – 370HelicalUniRule annotationAdd BLAST20
Topological domaini371 – 387CytoplasmicUniRule annotationAdd BLAST17
Transmembranei388 – 406HelicalUniRule annotationAdd BLAST19
Topological domaini407 – 412PeriplasmicUniRule annotation6

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi34D → E or N: Loss of function. 1 Publication1
Mutagenesisi35P → N or Q: Loss of function. 1 Publication1
Mutagenesisi36G → P: Loss of function. 1 Publication1
Mutagenesisi37N → D: Loss of function. 1 Publication1
Mutagenesisi102E → D or Q: Loss of function. 1 Publication1
Mutagenesisi109D → E or N: Transports manganese to a very low level. 1 Publication1
Mutagenesisi112E → D or Q: Transports manganese to a very low level. 1 Publication1
Mutagenesisi115G → A or P: Loss of function. 1 Publication1
Mutagenesisi154E → Q: Transports manganese to a level half of that of wild-type. 1 Publication1
Mutagenesisi238D → N: Transports manganese to a very low level. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126171 – 412Divalent metal cation transporter MntHAdd BLAST412

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A769

PRoteomics IDEntifications database

More...
PRIDEi
P0A769

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P093723EBI-551337,EBI-547441

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259183, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-48004N

Protein interaction database and analysis system

More...
IntActi
P0A769, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b2392

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A769

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAMP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C56 Bacteria
COG1914 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000152205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A769

KEGG Orthology (KO)

More...
KOi
K03322

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0A769

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00221 NRAMP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001046 NRAMP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11706 PTHR11706, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01566 Nramp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00447 NATRESASSCMP

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01197 nramp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNYRVESSS GRAARKMRLA LMGPAFIAAI GYIDPGNFAT NIQAGASFGY
60 70 80 90 100
QLLWVVVWAN LMAMLIQILS AKLGIATGKN LAEQIRDHYP RPVVWFYWVQ
110 120 130 140 150
AEIIAMATDL AEFIGAAIGF KLILGVSLLQ GAVLTGIATF LILMLQRRGQ
160 170 180 190 200
KPLEKVIGGL LLFVAAAYIV ELIFSQPNLA QLGKGMVIPS LPTSEAVFLA
210 220 230 240 250
AGVLGATIMP HVIYLHSSLT QHLHGGSRQQ RYSATKWDVA IAMTIAGFVN
260 270 280 290 300
LAMMATAAAA FHFSGHTGVA DLDEAYLTLQ PLLSHAAATV FGLSLVAAGL
310 320 330 340 350
SSTVVGTLAG QVVMQGFIRF HIPLWVRRTV TMLPSFIVIL MGLDPTRILV
360 370 380 390 400
MSQVLLSFGI ALALVPLLIF TSDSKLMGDL VNSKRVKQTG WVIVVLVVAL
410
NIWLLVGTAL GL
Length:412
Mass (Da):44,194
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D77FEAEA00411FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF161318 Genomic DNA Translation: AAD46617.1
U00096 Genomic DNA Translation: AAC75451.1
AP009048 Genomic DNA Translation: BAA16262.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E65013

NCBI Reference Sequences

More...
RefSeqi
NP_416893.1, NC_000913.3
WP_000186369.1, NZ_STEB01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75451; AAC75451; b2392
BAA16262; BAA16262; BAA16262

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946899

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2388
eco:b2392

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4337

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161318 Genomic DNA Translation: AAD46617.1
U00096 Genomic DNA Translation: AAC75451.1
AP009048 Genomic DNA Translation: BAA16262.1
PIRiE65013
RefSeqiNP_416893.1, NC_000913.3
WP_000186369.1, NZ_STEB01000008.1

3D structure databases

SMRiP0A769
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4259183, 8 interactors
DIPiDIP-48004N
IntActiP0A769, 1 interactor
STRINGi511145.b2392

Protein family/group databases

TCDBi2.A.55.3.1 the metal ion (mn(2+)-iron) transporter (nramp) family

Proteomic databases

PaxDbiP0A769
PRIDEiP0A769

Genome annotation databases

EnsemblBacteriaiAAC75451; AAC75451; b2392
BAA16262; BAA16262; BAA16262
GeneIDi946899
KEGGiecj:JW2388
eco:b2392
PATRICifig|1411691.4.peg.4337

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3909

Phylogenomic databases

eggNOGiENOG4105C56 Bacteria
COG1914 LUCA
HOGENOMiHOG000152205
InParanoidiP0A769
KOiK03322
PhylomeDBiP0A769

Enzyme and pathway databases

BioCyciEcoCyc:YFEP-MONOMER
ECOL316407:JW2388-MONOMER
MetaCyc:YFEP-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0A769

Family and domain databases

HAMAPiMF_00221 NRAMP, 1 hit
InterProiView protein in InterPro
IPR001046 NRAMP_fam
PANTHERiPTHR11706 PTHR11706, 1 hit
PfamiView protein in Pfam
PF01566 Nramp, 1 hit
PRINTSiPR00447 NATRESASSCMP
TIGRFAMsiTIGR01197 nramp, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMNTH_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A769
Secondary accession number(s): P77145
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 13, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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