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UniProtKB - P0A756 (KEFG_ECOLI)
Protein
Glutathione-regulated potassium-efflux system ancillary protein KefG
Gene
kefG
Organism
Escherichia coli (strain K12)
Status
Functioni
Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.
UniRule annotation1 PublicationCatalytic activityi
GO - Molecular functioni
- electron transfer activity Source: GO_Central
- FMN binding Source: GO_Central
- NAD(P)H dehydrogenase (quinone) activity Source: GO_Central
- NADH dehydrogenase (quinone) activity Source: RHEA
- NADPH dehydrogenase (quinone) activity Source: RHEA
GO - Biological processi
- positive regulation of ion transmembrane transporter activity Source: GO_Central
- positive regulation of potassium ion transmembrane transport Source: EcoCyc
- potassium ion transport Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:G7717-MONOMER |
Protein family/group databases
TCDBi | 2.A.37.1.2, the monovalent cation:proton antiporter-2 (cpa2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione-regulated potassium-efflux system ancillary protein KefGUniRule annotationAlternative name(s): Putative quinone oxidoreductase KefGUniRule annotation (EC:1.6.5.2UniRule annotation) |
Gene namesi | Name:kefGUniRule annotation Synonyms:yheR Ordered Locus Names:b3351, JW3314 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071642 | 1 – 184 | Glutathione-regulated potassium-efflux system ancillary protein KefGAdd BLAST | 184 |
Proteomic databases
jPOSTi | P0A756 |
PaxDbi | P0A756 |
PRIDEi | P0A756 |
Interactioni
Subunit structurei
Interacts with KefB.
UniRule annotationProtein-protein interaction databases
BioGRIDi | 4263025, 13 interactors 852168, 1 interactor |
ComplexPortali | CPX-3090, Glutathione-regulated potassium-efflux system KefB-KefG complex |
IntActi | P0A756, 6 interactors |
STRINGi | 511145.b3351 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG2249, Bacteria |
HOGENOMi | CLU_058643_0_1_6 |
InParanoidi | P0A756 |
PhylomeDBi | P0A756 |
Family and domain databases
Gene3Di | 3.40.50.360, 1 hit |
HAMAPi | MF_01415, K_H_efflux_KefG, 1 hit |
InterProi | View protein in InterPro IPR003680, Flavodoxin_fold IPR029039, Flavoprotein-like_sf IPR023947, K_H_efflux_KefG |
Pfami | View protein in Pfam PF02525, Flavodoxin_2, 1 hit |
SUPFAMi | SSF52218, SSF52218, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A756-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSQPAKVLL LYAHPESQDS VANRVLLKPA TQLSNVTVHD LYAHYPDFFI
60 70 80 90 100
DIPREQALLR EHEVIVFQHP LYTYSCPALL KEWLDRVLSR GFASGPGGNQ
110 120 130 140 150
LAGKYWRSVI TTGEPESAYR YDALNRYPMS DVLRPFELAA GMCRMHWLSP
160 170 180
IIIYWARRQS AQELASHARA YGDWLANPLS PGGR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58148.1 U00096 Genomic DNA Translation: AAC76376.1 AP009048 Genomic DNA Translation: BAE77939.1 |
PIRi | B65129 |
RefSeqi | NP_417810.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC76376; AAC76376; b3351 BAE77939; BAE77939; BAE77939 |
GeneIDi | 947857 |
KEGGi | ecj:JW3314 eco:b3351 |
PATRICi | fig|511145.12.peg.3445 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58148.1 U00096 Genomic DNA Translation: AAC76376.1 AP009048 Genomic DNA Translation: BAE77939.1 |
PIRi | B65129 |
RefSeqi | NP_417810.1, NC_000913.3 |
3D structure databases
SMRi | P0A756 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263025, 13 interactors 852168, 1 interactor |
ComplexPortali | CPX-3090, Glutathione-regulated potassium-efflux system KefB-KefG complex |
IntActi | P0A756, 6 interactors |
STRINGi | 511145.b3351 |
Protein family/group databases
TCDBi | 2.A.37.1.2, the monovalent cation:proton antiporter-2 (cpa2) family |
Proteomic databases
jPOSTi | P0A756 |
PaxDbi | P0A756 |
PRIDEi | P0A756 |
Genome annotation databases
EnsemblBacteriai | AAC76376; AAC76376; b3351 BAE77939; BAE77939; BAE77939 |
GeneIDi | 947857 |
KEGGi | ecj:JW3314 eco:b3351 |
PATRICi | fig|511145.12.peg.3445 |
Organism-specific databases
EchoBASEi | EB2739 |
Phylogenomic databases
eggNOGi | COG2249, Bacteria |
HOGENOMi | CLU_058643_0_1_6 |
InParanoidi | P0A756 |
PhylomeDBi | P0A756 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7717-MONOMER |
Miscellaneous databases
PROi | PR:P0A756 |
Family and domain databases
Gene3Di | 3.40.50.360, 1 hit |
HAMAPi | MF_01415, K_H_efflux_KefG, 1 hit |
InterProi | View protein in InterPro IPR003680, Flavodoxin_fold IPR029039, Flavoprotein-like_sf IPR023947, K_H_efflux_KefG |
Pfami | View protein in Pfam PF02525, Flavodoxin_2, 1 hit |
SUPFAMi | SSF52218, SSF52218, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KEFG_ECOLI | |
Accessioni | P0A756Primary (citable) accession number: P0A756 Secondary accession number(s): P45534, Q2M717 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families