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Protein

Cell division topological specificity factor

Gene

minE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • division septum site selection Source: EcoCyc
  • regulation of cell division Source: EcoliWiki
  • regulation of division septum assembly Source: EcoliWiki

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG10598-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division topological specificity factor
Gene namesi
Name:minE
Ordered Locus Names:b1174, JW1163
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10598 minE

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

In a minCDE operon disruption (minC-minD-minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058741 – 88Cell division topological specificity factorAdd BLAST88

Proteomic databases

EPDiP0A734
PaxDbiP0A734
PRIDEiP0A734

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4262867, 340 interactors
DIPiDIP-35912N
IntActiP0A734, 19 interactors
STRINGi316385.ECDH10B_1227

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A734
SMRiP0A734
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A734

Family & Domainsi

Sequence similaritiesi

Belongs to the MinE family.Curated

Phylogenomic databases

eggNOGiENOG4105VJP Bacteria
COG0851 LUCA
HOGENOMiHOG000218362
InParanoidiP0A734
KOiK03608
OMAiMLSVQFE
PhylomeDBiP0A734

Family and domain databases

Gene3Di3.30.1070.10, 1 hit
HAMAPiMF_00262 MinE, 1 hit
InterProiView protein in InterPro
IPR005527 MinE
IPR036707 MinE_sf
PANTHERiPTHR33404 PTHR33404, 1 hit
PfamiView protein in Pfam
PF03776 MinE, 1 hit
SUPFAMiSSF55229 SSF55229, 1 hit
TIGRFAMsiTIGR01215 minE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A734-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLDFFLSR KKNTANIAKE RLQIIVAERR RSDAEPHYLP QLRKDILEVI
60 70 80
CKYVQIDPEM VTVQLEQKDG DISILELNVT LPEAEELK
Length:88
Mass (Da):10,235
Last modified:June 7, 2005 - v1
Checksum:i04DDFB4EA24F96C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03153 Genomic DNA Translation: AAB59063.1
U00096 Genomic DNA Translation: AAC74258.1
AP009048 Genomic DNA Translation: BAA36008.1
PIRiC31877 CEECTF
RefSeqiNP_415692.1, NC_000913.3
WP_001185665.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74258; AAC74258; b1174
BAA36008; BAA36008; BAA36008
GeneIDi945740
KEGGiecj:JW1163
eco:b1174
PATRICifig|1411691.4.peg.1114

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03153 Genomic DNA Translation: AAB59063.1
U00096 Genomic DNA Translation: AAC74258.1
AP009048 Genomic DNA Translation: BAA36008.1
PIRiC31877 CEECTF
RefSeqiNP_415692.1, NC_000913.3
WP_001185665.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EV0NMR-A/B31-88[»]
3R9IX-ray2.60E/F/G/H12-31[»]
3R9JX-ray4.30C/D12-88[»]
ProteinModelPortaliP0A734
SMRiP0A734
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262867, 340 interactors
DIPiDIP-35912N
IntActiP0A734, 19 interactors
STRINGi316385.ECDH10B_1227

Proteomic databases

EPDiP0A734
PaxDbiP0A734
PRIDEiP0A734

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74258; AAC74258; b1174
BAA36008; BAA36008; BAA36008
GeneIDi945740
KEGGiecj:JW1163
eco:b1174
PATRICifig|1411691.4.peg.1114

Organism-specific databases

EchoBASEiEB0593
EcoGeneiEG10598 minE

Phylogenomic databases

eggNOGiENOG4105VJP Bacteria
COG0851 LUCA
HOGENOMiHOG000218362
InParanoidiP0A734
KOiK03608
OMAiMLSVQFE
PhylomeDBiP0A734

Enzyme and pathway databases

BioCyciEcoCyc:EG10598-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A734
PROiPR:P0A734

Family and domain databases

Gene3Di3.30.1070.10, 1 hit
HAMAPiMF_00262 MinE, 1 hit
InterProiView protein in InterPro
IPR005527 MinE
IPR036707 MinE_sf
PANTHERiPTHR33404 PTHR33404, 1 hit
PfamiView protein in Pfam
PF03776 MinE, 1 hit
SUPFAMiSSF55229 SSF55229, 1 hit
TIGRFAMsiTIGR01215 minE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMINE_ECOLI
AccessioniPrimary (citable) accession number: P0A734
Secondary accession number(s): P18198
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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