UniProtKB - P0A734 (MINE_ECOLI)
Protein
Cell division topological specificity factor
Gene
minE
Organism
Escherichia coli (strain K12)
Status
Functioni
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.1 Publication
GO - Molecular functioni
- identical protein binding Source: EcoCyc
GO - Biological processi
- division septum site selection Source: EcoCyc
- regulation of cell division Source: EcoliWiki
- regulation of division septum assembly Source: EcoliWiki
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10598-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division topological specificity factor |
Gene namesi | Name:minE Ordered Locus Names:b1174, JW1163 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
In a minCDE operon disruption (minC-minD-minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205874 | 1 – 88 | Cell division topological specificity factorAdd BLAST | 88 |
Proteomic databases
jPOSTi | P0A734 |
PaxDbi | P0A734 |
PRIDEi | P0A734 |
Interactioni
Binary interactionsi
Hide detailsP0A734
With | #Exp. | IntAct |
---|---|---|
minD [P0AEZ3] | 4 | EBI-1118020,EBI-554545 |
itself | 4 | EBI-1118020,EBI-1118020 |
GO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4262867, 340 interactors 850107, 4 interactors |
DIPi | DIP-35912N |
IntActi | P0A734, 19 interactors |
STRINGi | 511145.b1174 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A734 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A734 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MinE family.Curated
Phylogenomic databases
eggNOGi | COG0851, Bacteria |
HOGENOMi | CLU_137929_2_2_6 |
InParanoidi | P0A734 |
PhylomeDBi | P0A734 |
Family and domain databases
Gene3Di | 3.30.1070.10, 1 hit |
HAMAPi | MF_00262, MinE, 1 hit |
InterProi | View protein in InterPro IPR005527, MinE IPR036707, MinE_sf |
Pfami | View protein in Pfam PF03776, MinE, 1 hit |
SUPFAMi | SSF55229, SSF55229, 1 hit |
TIGRFAMsi | TIGR01215, minE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A734-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLDFFLSR KKNTANIAKE RLQIIVAERR RSDAEPHYLP QLRKDILEVI
60 70 80
CKYVQIDPEM VTVQLEQKDG DISILELNVT LPEAEELK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03153 Genomic DNA Translation: AAB59063.1 U00096 Genomic DNA Translation: AAC74258.1 AP009048 Genomic DNA Translation: BAA36008.1 |
PIRi | C31877, CEECTF |
RefSeqi | NP_415692.1, NC_000913.3 WP_001185665.1, NZ_STEB01000023.1 |
Genome annotation databases
EnsemblBacteriai | AAC74258; AAC74258; b1174 BAA36008; BAA36008; BAA36008 |
GeneIDi | 58463908 945740 |
KEGGi | ecj:JW1163 eco:b1174 |
PATRICi | fig|1411691.4.peg.1114 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03153 Genomic DNA Translation: AAB59063.1 U00096 Genomic DNA Translation: AAC74258.1 AP009048 Genomic DNA Translation: BAA36008.1 |
PIRi | C31877, CEECTF |
RefSeqi | NP_415692.1, NC_000913.3 WP_001185665.1, NZ_STEB01000023.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EV0 | NMR | - | A/B | 31-88 | [»] | |
3R9I | X-ray | 2.60 | E/F/G/H | 12-31 | [»] | |
3R9J | X-ray | 4.30 | C/D | 12-88 | [»] | |
SMRi | P0A734 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262867, 340 interactors 850107, 4 interactors |
DIPi | DIP-35912N |
IntActi | P0A734, 19 interactors |
STRINGi | 511145.b1174 |
Proteomic databases
jPOSTi | P0A734 |
PaxDbi | P0A734 |
PRIDEi | P0A734 |
Genome annotation databases
EnsemblBacteriai | AAC74258; AAC74258; b1174 BAA36008; BAA36008; BAA36008 |
GeneIDi | 58463908 945740 |
KEGGi | ecj:JW1163 eco:b1174 |
PATRICi | fig|1411691.4.peg.1114 |
Organism-specific databases
EchoBASEi | EB0593 |
Phylogenomic databases
eggNOGi | COG0851, Bacteria |
HOGENOMi | CLU_137929_2_2_6 |
InParanoidi | P0A734 |
PhylomeDBi | P0A734 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10598-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A734 |
PROi | PR:P0A734 |
Family and domain databases
Gene3Di | 3.30.1070.10, 1 hit |
HAMAPi | MF_00262, MinE, 1 hit |
InterProi | View protein in InterPro IPR005527, MinE IPR036707, MinE_sf |
Pfami | View protein in Pfam PF03776, MinE, 1 hit |
SUPFAMi | SSF55229, SSF55229, 1 hit |
TIGRFAMsi | TIGR01215, minE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MINE_ECOLI | |
Accessioni | P0A734Primary (citable) accession number: P0A734 Secondary accession number(s): P18198 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | February 10, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families