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Protein

Probable intracellular septation protein A

Gene

yciB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cell division; probably involved in intracellular septation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG11122-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable intracellular septation protein AUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yciBUniRule annotation
Synonyms:ispZ
Ordered Locus Names:b1254, JW1246
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG11122 yciB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21PeriplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Topological domaini43 – 49CytoplasmicSequence analysis7
Transmembranei50 – 70HelicalUniRule annotationAdd BLAST21
Topological domaini71 – 75PeriplasmicSequence analysis5
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Topological domaini97 – 120CytoplasmicSequence analysisAdd BLAST24
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Topological domaini142 – 148PeriplasmicSequence analysis7
Transmembranei149 – 169HelicalUniRule annotationAdd BLAST21
Topological domaini170 – 179CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065311 – 179Probable intracellular septation protein AAdd BLAST179

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A710

PRoteomics IDEntifications database

More...
PRIDEi
P0A710

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4262998, 140 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_1369

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0A710

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the YciB family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107835 Bacteria
COG2917 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000062588

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A710

KEGG Orthology (KO)

More...
KOi
K06190

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0A710

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00189 Intracell_septation_prot_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006008 Intracell_sepatation_prot_A

The PANTHER Classification System

More...
PANTHERi
PTHR36917 PTHR36917, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04279 IspA, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00997 ispZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A710-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQFLDFLPL VVFFAFYKIY DIYAATAALI VATAIVLIYS WVRFRKVEKM
60 70 80 90 100
ALITFVLVVV FGGLTLFFHN DEFIKWKVTV IYALFAGALL VSQWVMKKPL
110 120 130 140 150
IQRMLGKELT LPQPVWSKLN LAWAVFFILC GLANIYIAFW LPQNIWVNFK
160 170
VFGLTALTLI FTLLSGIYIY RHMPQEDKS
Length:179
Mass (Da):20,790
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A52B2D9CA996EEF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti99P → Q in strain: ECOR 31. 1
Natural varianti110T → M in strain: ECOR 28. 1
Natural varianti111L → V in strain: ECOR 60. 1
Natural varianti114P → S in strain: ECOR 52. 1
Natural varianti117S → L in strain: ECOR 28. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13583 Genomic DNA Translation: CAA31924.1
U24195 Genomic DNA Translation: AAB60067.1
U24196 Genomic DNA Translation: AAB60075.1
U24197 Genomic DNA Translation: AAB60083.1
U24198 Genomic DNA Translation: AAB60091.1
U24199 Genomic DNA Translation: AAB60099.1
U24200 Genomic DNA Translation: AAB60107.1
U24201 Genomic DNA Translation: AAB60115.1
U24202 Genomic DNA Translation: AAB60123.1
U24203 Genomic DNA Translation: AAB60131.1
U24204 Genomic DNA Translation: AAB60139.1
U24205 Genomic DNA Translation: AAB60147.1
U24206 Genomic DNA Translation: AAB60155.1
U00096 Genomic DNA Translation: AAC74336.1
AP009048 Genomic DNA Translation: BAA14786.1

Protein sequence database of the Protein Information Resource

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PIRi
S07799
T45503

NCBI Reference Sequences

More...
RefSeqi
NP_415770.1, NC_000913.3
WP_000808667.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74336; AAC74336; b1254
BAA14786; BAA14786; BAA14786

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1246
eco:b1254

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1029

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13583 Genomic DNA Translation: CAA31924.1
U24195 Genomic DNA Translation: AAB60067.1
U24196 Genomic DNA Translation: AAB60075.1
U24197 Genomic DNA Translation: AAB60083.1
U24198 Genomic DNA Translation: AAB60091.1
U24199 Genomic DNA Translation: AAB60099.1
U24200 Genomic DNA Translation: AAB60107.1
U24201 Genomic DNA Translation: AAB60115.1
U24202 Genomic DNA Translation: AAB60123.1
U24203 Genomic DNA Translation: AAB60131.1
U24204 Genomic DNA Translation: AAB60139.1
U24205 Genomic DNA Translation: AAB60147.1
U24206 Genomic DNA Translation: AAB60155.1
U00096 Genomic DNA Translation: AAC74336.1
AP009048 Genomic DNA Translation: BAA14786.1
PIRiS07799
T45503
RefSeqiNP_415770.1, NC_000913.3
WP_000808667.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0A710
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262998, 140 interactors
STRINGi316385.ECDH10B_1369

Proteomic databases

PaxDbiP0A710
PRIDEiP0A710

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74336; AAC74336; b1254
BAA14786; BAA14786; BAA14786
GeneIDi946228
KEGGiecj:JW1246
eco:b1254
PATRICifig|1411691.4.peg.1029

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1112
EcoGeneiEG11122 yciB

Phylogenomic databases

eggNOGiENOG4107835 Bacteria
COG2917 LUCA
HOGENOMiHOG000062588
InParanoidiP0A710
KOiK06190
PhylomeDBiP0A710

Enzyme and pathway databases

BioCyciEcoCyc:EG11122-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0A710

Family and domain databases

HAMAPiMF_00189 Intracell_septation_prot_A, 1 hit
InterProiView protein in InterPro
IPR006008 Intracell_sepatation_prot_A
PANTHERiPTHR36917 PTHR36917, 1 hit
PfamiView protein in Pfam
PF04279 IspA, 1 hit
TIGRFAMsiTIGR00997 ispZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYCIB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A710
Secondary accession number(s): P21366
, P94721, P94725, P94735, P94738
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: December 5, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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