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Entry version 134 (07 Oct 2020)
Sequence version 1 (07 Jun 2005)
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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the essential components for the initiation of protein synthesis. May protect N-formylmethionyl-tRNA(fMet) from spontaneous hydrolysis. Promotes N-formylmethionyl-tRNA(fMet) binding to the 30S pre-initiation complex (PIC) (PubMed:1764105, PubMed:20224578). Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Upon addition of the 50S ribosomal subunit, IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.4 Publications

Miscellaneous

When overexpressed partially suppresses the slow growth and decreased 70S ribosome phenotype of an rsgA knockout; RsgA may be involved in 30S ribosomal subunit biogenesis.1 Publication
Silent mutations of codon 158, which no longer function as alternative start codons, decrease beta isoform expression to 31 to 50%, the strongest mutation is GUG to GUC.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi398 – 405GTPBy similarity8
Nucleotide bindingi444 – 448GTPBy similarity5
Nucleotide bindingi498 – 501GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10505-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translation initiation factor IF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:infB
Synonyms:gicD, ssyG
Ordered Locus Names:b3168, JW3137
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Essential, it cannot be deleted. The C-terminal region (residues 165-890) is sufficient for growth at 42 degrees Celsius, although it grows more slowly at 37 degrees and is cold-sensitive at 30 degrees Celsius (PubMed:1374802).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi158V → A: Produces 35% of isoform beta (i.e. only beta2). 1 Publication1
Mutagenesisi158V → E: Produces 70% of isoform beta (i.e. only beta2). 1 Publication1
Mutagenesisi158V → G: Produces 66% of isoform beta (i.e. only beta2). 1 Publication1
Mutagenesisi165M → I or T: Produces reduces amount of isoform beta (i.e. only beta1). Reduced growth at 37 degrees Celsius, greatly reduced growth at 30 degrees Celsius. Growth is more impaired; when associated with silent V-158 GUG to GUC. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002387851 – 890Translation initiation factor IF-2Add BLAST890

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei808N6-acetyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A proteolyzed form, called IF2 gamma (begins with residue 290), can be detected during purification which has all the activities expected for this protein, although it is slightly less efficient than full-length protein. It is not clear if it exists in vivo.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0A705

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A705

PRoteomics IDEntifications database

More...
PRIDEi
P0A705

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0A705

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Part of the metY operon that extends to pnp (PubMed:2849753).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4262436, 45 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2244, Translation initiation factor complex

Database of interacting proteins

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DIPi
DIP-36182N

Protein interaction database and analysis system

More...
IntActi
P0A705, 51 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3168

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1890
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A705

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0A705

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini389 – 558tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1031Add BLAST103
Regioni104 – 2872Add BLAST184
Regioni288 – 3913Add BLAST104
Regioni398 – 405G1By similarity8
Regioni423 – 427G2By similarity5
Regioni444 – 447G3By similarity4
Regioni498 – 501G4By similarity4
Regioni534 – 536G5By similarity3
Regioni541 – 6685Add BLAST128
Regioni669 – 8906Add BLAST222

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi167 – 214Ala/Arg/Glu/Lys-richAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0532, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006301_6_3_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A705

KEGG Orthology (KO)

More...
KOi
K02519

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0A705

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10050, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00100_B, IF_2_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009061, DNA-bd_dom_put_sf
IPR013575, IF2_assoc_dom_bac
IPR006847, IF2_N
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR000795, TF_GTP-bd_dom
IPR000178, TF_IF2_bacterial-like
IPR015760, TIF_IF2
IPR023115, TIF_IF2_dom3
IPR036925, TIF_IF2_dom3_sf
IPR009000, Transl_B-barrel_sf

The PANTHER Classification System

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PANTHERi
PTHR43381, PTHR43381, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00009, GTP_EFTU, 1 hit
PF11987, IF-2, 1 hit
PF08364, IF2_assoc, 1 hit
PF04760, IF2_N, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955, SSF46955, 1 hit
SSF50447, SSF50447, 2 hits
SSF52156, SSF52156, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00487, IF-2, 1 hit
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51722, G_TR_2, 1 hit
PS01176, IF2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform Alpha1 Publication (identifier: P0A705-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDVTIKTLA AERQTSVERL VQQFADAGIR KSADDSVSAQ EKQTLIDHLN
60 70 80 90 100
QKNSGPDKLT LQRKTRSTLN IPGTGGKSKS VQIEVRKKRT FVKRDPQEAE
110 120 130 140 150
RLAAEEQAQR EAEEQARREA EESAKREAQQ KAEREAAEQA KREAAEQAKR
160 170 180 190 200
EAAEKDKVSN QQDDMTKNAQ AEKARREQEA AELKRKAEEE ARRKLEEEAR
210 220 230 240 250
RVAEEARRMA EENKWTDNAE PTEDSSDYHV TTSQHARQAE DESDREVEGG
260 270 280 290 300
RGRGRNAKAA RPKKGNKHAE SKADREEARA AVRGGKGGKR KGSSLQQGFQ
310 320 330 340 350
KPAQAVNRDV VIGETITVGE LANKMAVKGS QVIKAMMKLG AMATINQVID
360 370 380 390 400
QETAQLVAEE MGHKVILRRE NELEEAVMSD RDTGAAAEPR APVVTIMGHV
410 420 430 440 450
DHGKTSLLDY IRSTKVASGE AGGITQHIGA YHVETENGMI TFLDTPGHAA
460 470 480 490 500
FTSMRARGAQ ATDIVVLVVA ADDGVMPQTI EAIQHAKAAQ VPVVVAVNKI
510 520 530 540 550
DKPEADPDRV KNELSQYGIL PEEWGGESQF VHVSAKAGTG IDELLDAILL
560 570 580 590 600
QAEVLELKAV RKGMASGAVI ESFLDKGRGP VATVLVREGT LHKGDIVLCG
610 620 630 640 650
FEYGRVRAMR NELGQEVLEA GPSIPVEILG LSGVPAAGDE VTVVRDEKKA
660 670 680 690 700
REVALYRQGK FREVKLARQQ KSKLENMFAN MTEGEVHEVN IVLKADVQGS
710 720 730 740 750
VEAISDSLLK LSTDEVKVKI IGSGVGGITE TDATLAAASN AILVGFNVRA
760 770 780 790 800
DASARKVIEA ESLDLRYYSV IYNLIDEVKA AMSGMLSPEL KQQIIGLAEV
810 820 830 840 850
RDVFKSPKFG AIAGCMVTEG VVKRHNPIRV LRDNVVIYEG ELESLRRFKD
860 870 880 890
DVNEVRNGME CGIGVKNYND VRTGDVIEVF EIIEIQRTIA
Note: Isoform alpha is approximately 2-fold more abundant than the combined beta isoforms. Optimal growth requires both alpha and beta IF2.1 Publication
Length:890
Mass (Da):97,350
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86B9F9B2AE773DDE
GO
Isoform Beta3 Publications (identifier: P0A705-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     158-158: V → M

Note: Also called beta1.1 Publication
Show »
Length:733
Mass (Da):79,745
Checksum:iA85674E0145D5E66
GO
Isoform Beta'2 Publications (identifier: P0A705-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: Also called beta2.1 Publication
Show »
Length:726
Mass (Da):78,927
Checksum:i08C16925C01D0199
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti409D → E in strain: IQ489. 1
Natural varianti423G → GG in strain: IQ490. 1
Natural varianti432H → Q in strain: ECOAU9326. 1
Natural varianti490Q → G in strain: ECOAU9302, ECOAU9306, ECOAU9307 and ECOAU9309. 1
Natural varianti684G → A in strain: ECOAU9306. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187601 – 164Missing in isoform Beta'. Curated2 PublicationsAdd BLAST164
Alternative sequenceiVSP_0187581 – 157Missing in isoform Beta. Curated3 PublicationsAdd BLAST157
Alternative sequenceiVSP_018759158V → M in isoform Beta. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00513 Genomic DNA Translation: CAA25201.1
X00513 Genomic DNA Translation: CAA25202.1
U18997 Genomic DNA Translation: AAA57971.1
U00096 Genomic DNA Translation: AAC76202.1
AP009048 Genomic DNA Translation: BAE77214.1
AJ002537 Genomic DNA Translation: CAA05529.1
AJ002537 Genomic DNA Translation: CAA05530.1
AJ002537 Genomic DNA Translation: CAA05531.1
AJ002538 Genomic DNA Translation: CAA05532.1
AJ002538 Genomic DNA Translation: CAA05533.1
AJ002538 Genomic DNA Translation: CAA05534.1
AJ002539 Genomic DNA Translation: CAA05535.1
AJ002539 Genomic DNA Translation: CAA05536.1
AJ002539 Genomic DNA Translation: CAA05537.1
AJ002540 Genomic DNA Translation: CAA05538.1
AJ002540 Genomic DNA Translation: CAA05539.1
AJ002540 Genomic DNA Translation: CAA05540.1
AJ002541 Genomic DNA Translation: CAA05541.1
AJ002541 Genomic DNA Translation: CAA05542.1
AJ002541 Genomic DNA Translation: CAA05543.1
AJ002542 Genomic DNA Translation: CAA05544.1
AJ002542 Genomic DNA Translation: CAA05545.1
AJ002542 Genomic DNA Translation: CAA05546.1
AJ002402 Genomic DNA Translation: CAA05386.1
AJ002403 Genomic DNA Translation: CAA05387.1
AJ002404 Genomic DNA Translation: CAA05388.1
AJ002405 Genomic DNA Translation: CAA05389.1
AJ002406 Genomic DNA Translation: CAA05390.1
AJ002407 Genomic DNA Translation: CAA05391.1
AJ002408 Genomic DNA Translation: CAA05392.1
AJ002409 Genomic DNA Translation: CAA05393.1
AJ002410 Genomic DNA Translation: CAA05394.1
AJ002411 Genomic DNA Translation: CAA05395.1
AJ002412 Genomic DNA Translation: CAA05396.1
AJ002413 Genomic DNA Translation: CAA05397.1
AJ132861 Genomic DNA Translation: CAC20126.1
AJ132861 Genomic DNA Translation: CAC20127.1
AJ132861 Genomic DNA Translation: CAC20128.1
AJ132862 Genomic DNA Translation: CAC20130.1
AJ132862 Genomic DNA Translation: CAC20131.1
AJ132862 Genomic DNA Translation: CAC20132.1
X13775 Genomic DNA Translation: CAA32019.1

Protein sequence database of the Protein Information Resource

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PIRi
D65107, FIEC2

NCBI Reference Sequences

More...
RefSeqi
NP_417637.1, NC_000913.3
WP_000133044.1, NZ_STEB01000012.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
AAC76202; AAC76202; b3168
BAE77214; BAE77214; BAE77214

Database of genes from NCBI RefSeq genomes

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GeneIDi
947684

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ecj:JW3137
eco:b3168

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|511145.12.peg.3263

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00513 Genomic DNA Translation: CAA25201.1
X00513 Genomic DNA Translation: CAA25202.1
U18997 Genomic DNA Translation: AAA57971.1
U00096 Genomic DNA Translation: AAC76202.1
AP009048 Genomic DNA Translation: BAE77214.1
AJ002537 Genomic DNA Translation: CAA05529.1
AJ002537 Genomic DNA Translation: CAA05530.1
AJ002537 Genomic DNA Translation: CAA05531.1
AJ002538 Genomic DNA Translation: CAA05532.1
AJ002538 Genomic DNA Translation: CAA05533.1
AJ002538 Genomic DNA Translation: CAA05534.1
AJ002539 Genomic DNA Translation: CAA05535.1
AJ002539 Genomic DNA Translation: CAA05536.1
AJ002539 Genomic DNA Translation: CAA05537.1
AJ002540 Genomic DNA Translation: CAA05538.1
AJ002540 Genomic DNA Translation: CAA05539.1
AJ002540 Genomic DNA Translation: CAA05540.1
AJ002541 Genomic DNA Translation: CAA05541.1
AJ002541 Genomic DNA Translation: CAA05542.1
AJ002541 Genomic DNA Translation: CAA05543.1
AJ002542 Genomic DNA Translation: CAA05544.1
AJ002542 Genomic DNA Translation: CAA05545.1
AJ002542 Genomic DNA Translation: CAA05546.1
AJ002402 Genomic DNA Translation: CAA05386.1
AJ002403 Genomic DNA Translation: CAA05387.1
AJ002404 Genomic DNA Translation: CAA05388.1
AJ002405 Genomic DNA Translation: CAA05389.1
AJ002406 Genomic DNA Translation: CAA05390.1
AJ002407 Genomic DNA Translation: CAA05391.1
AJ002408 Genomic DNA Translation: CAA05392.1
AJ002409 Genomic DNA Translation: CAA05393.1
AJ002410 Genomic DNA Translation: CAA05394.1
AJ002411 Genomic DNA Translation: CAA05395.1
AJ002412 Genomic DNA Translation: CAA05396.1
AJ002413 Genomic DNA Translation: CAA05397.1
AJ132861 Genomic DNA Translation: CAC20126.1
AJ132861 Genomic DNA Translation: CAC20127.1
AJ132861 Genomic DNA Translation: CAC20128.1
AJ132862 Genomic DNA Translation: CAC20130.1
AJ132862 Genomic DNA Translation: CAC20131.1
AJ132862 Genomic DNA Translation: CAC20132.1
X13775 Genomic DNA Translation: CAA32019.1
PIRiD65107, FIEC2
RefSeqiNP_417637.1, NC_000913.3
WP_000133044.1, NZ_STEB01000012.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ND9NMR-A2-50[»]
1ZO1electron microscopy13.80I388-888[»]
3JCJelectron microscopy3.70f1-890[»]
3JCNelectron microscopy4.60b1-890[»]
5ME0electron microscopy13.50W1-890[»]
5ME1electron microscopy13.50W1-890[»]
6O9Kelectron microscopy4.00z382-890[»]
SMRiP0A705
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4262436, 45 interactors
ComplexPortaliCPX-2244, Translation initiation factor complex
DIPiDIP-36182N
IntActiP0A705, 51 interactors
STRINGi511145.b3168

PTM databases

iPTMnetiP0A705

Proteomic databases

jPOSTiP0A705
PaxDbiP0A705
PRIDEiP0A705

Genome annotation databases

EnsemblBacteriaiAAC76202; AAC76202; b3168
BAE77214; BAE77214; BAE77214
GeneIDi947684
KEGGiecj:JW3137
eco:b3168
PATRICifig|511145.12.peg.3263

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

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EchoBASEi
EB0500

Phylogenomic databases

eggNOGiCOG0532, Bacteria
HOGENOMiCLU_006301_6_3_6
InParanoidiP0A705
KOiK02519
PhylomeDBiP0A705

Enzyme and pathway databases

BioCyciEcoCyc:EG10505-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A705

Protein Ontology

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PROi
PR:P0A705

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B, IF_2_B, 1 hit
InterProiView protein in InterPro
IPR009061, DNA-bd_dom_put_sf
IPR013575, IF2_assoc_dom_bac
IPR006847, IF2_N
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR000795, TF_GTP-bd_dom
IPR000178, TF_IF2_bacterial-like
IPR015760, TIF_IF2
IPR023115, TIF_IF2_dom3
IPR036925, TIF_IF2_dom3_sf
IPR009000, Transl_B-barrel_sf
PANTHERiPTHR43381, PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009, GTP_EFTU, 1 hit
PF11987, IF-2, 1 hit
PF08364, IF2_assoc, 1 hit
PF04760, IF2_N, 2 hits
SUPFAMiSSF46955, SSF46955, 1 hit
SSF50447, SSF50447, 2 hits
SSF52156, SSF52156, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00487, IF-2, 1 hit
TIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722, G_TR_2, 1 hit
PS01176, IF2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF2_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A705
Secondary accession number(s): O32548
, O32549, O32550, O34379, O34415, O34603, P02995, Q2M942, Q9EUZ4, Q9EUZ5, Q9EUZ6, Q9EUZ8, Q9EUZ9, Q9EV00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 7, 2005
Last modified: October 7, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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