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Protein

Chaperone protein HtpG

Gene

htpG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone. Has ATPase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATP1 Publication1
Binding sitei80ATP1 Publication1
Binding sitei127ATP; via amide nitrogen1 Publication1
Binding sitei174ATP1 Publication1
Binding sitei255ATP1 Publication1

GO - Molecular functioni

  • ATPase activity Source: CACAO
  • ATPase activity, coupled Source: EcoCyc
  • ATP binding Source: UniProtKB-UniRule
  • identical protein binding Source: IntAct
  • unfolded protein binding Source: UniProtKB-UniRule

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • protein folding Source: EcoCyc
  • response to heat Source: EcoliWiki

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10461-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HtpG
Alternative name(s):
Heat shock protein C62.5
Heat shock protein HtpG
High temperature protein G
Gene namesi
Name:htpG
Ordered Locus Names:b0473, JW0462
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10461 htpG

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629851 – 624Chaperone protein HtpGAdd BLAST624

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0A6Z3
PaxDbiP0A6Z3
PRIDEiP0A6Z3

2D gel databases

SWISS-2DPAGEiP0A6Z3

PTM databases

CarbonylDBiP0A6Z3

Interactioni

Subunit structurei

Homodimer. Oligomerizes at 65 degrees Celsius.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261971, 211 interactors
DIPiDIP-29797N
IntActiP0A6Z3, 62 interactors
STRINGi316385.ECDH10B_0429

Structurei

Secondary structure

1624
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A6Z3
SMRiP0A6Z3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6Z3

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 336A; substrate-bindingAdd BLAST336
Regioni337 – 552BAdd BLAST216
Regioni553 – 624CAdd BLAST72
Regioni585 – 624Mediates dimerizationAdd BLAST40

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiENOG4105CJX Bacteria
COG0326 LUCA
HOGENOMiHOG000031989
InParanoidiP0A6Z3
KOiK04079
OMAiSDHEIFL
PhylomeDBiP0A6Z3

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6Z3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGQETRGFQ SEVKQLLHLM IHSLYSNKEI FLRELISNAS DAADKLRFRA
60 70 80 90 100
LSNPDLYEGD GELRVRVSFD KDKRTLTISD NGVGMTRDEV IDHLGTIAKS
110 120 130 140 150
GTKSFLESLG SDQAKDSQLI GQFGVGFYSA FIVADKVTVR TRAAGEKPEN
160 170 180 190 200
GVFWESAGEG EYTVADITKE DRGTEITLHL REGEDEFLDD WRVRSIISKY
210 220 230 240 250
SDHIALPVEI EKREEKDGET VISWEKINKA QALWTRNKSE ITDEEYKEFY
260 270 280 290 300
KHIAHDFNDP LTWSHNRVEG KQEYTSLLYI PSQAPWDMWN RDHKHGLKLY
310 320 330 340 350
VQRVFIMDDA EQFMPNYLRF VRGLIDSSDL PLNVSREILQ DSTVTRNLRN
360 370 380 390 400
ALTKRVLQML EKLAKDDAEK YQTFWQQFGL VLKEGPAEDF ANQEAIAKLL
410 420 430 440 450
RFASTHTDSS AQTVSLEDYV SRMKEGQEKI YYITADSYAA AKSSPHLELL
460 470 480 490 500
RKKGIEVLLL SDRIDEWMMN YLTEFDGKPF QSVSKVDESL EKLADEVDES
510 520 530 540 550
AKEAEKALTP FIDRVKALLG ERVKDVRLTH RLTDTPAIVS TDADEMSTQM
560 570 580 590 600
AKLFAAAGQK VPEVKYIFEL NPDHVLVKRA ADTEDEAKFS EWVELLLDQA
610 620
LLAERGTLED PNLFIRRMNQ LLVS
Length:624
Mass (Da):71,423
Last modified:June 7, 2005 - v1
Checksum:i1410577B589ADBAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38777 Genomic DNA Translation: AAA23460.1
U82664 Genomic DNA Translation: AAB40227.1
U00096 Genomic DNA Translation: AAC73575.1
AP009048 Genomic DNA Translation: BAE76252.1
PIRiA28324 HHEC62
RefSeqiNP_415006.1, NC_000913.3
WP_000678201.1, NZ_CP014272.1

Genome annotation databases

EnsemblBacteriaiAAC73575; AAC73575; b0473
BAE76252; BAE76252; BAE76252
GeneIDi945099
KEGGiecj:JW0462
eco:b0473
PATRICifig|1411691.4.peg.1803

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38777 Genomic DNA Translation: AAA23460.1
U82664 Genomic DNA Translation: AAB40227.1
U00096 Genomic DNA Translation: AAC73575.1
AP009048 Genomic DNA Translation: BAE76252.1
PIRiA28324 HHEC62
RefSeqiNP_415006.1, NC_000913.3
WP_000678201.1, NZ_CP014272.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SF8X-ray2.60A/B/C/D/E/F/G/H511-624[»]
1Y4SX-ray2.90A/B1-559[»]
1Y4UX-ray2.90A/B1-559[»]
2GQ0X-ray1.90A/B230-495[»]
2IOPX-ray3.55A/B/C/D1-624[»]
2IOQX-ray3.50A/B1-624[»]
2IORX-ray1.65A1-215[»]
ProteinModelPortaliP0A6Z3
SMRiP0A6Z3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261971, 211 interactors
DIPiDIP-29797N
IntActiP0A6Z3, 62 interactors
STRINGi316385.ECDH10B_0429

PTM databases

CarbonylDBiP0A6Z3

2D gel databases

SWISS-2DPAGEiP0A6Z3

Proteomic databases

EPDiP0A6Z3
PaxDbiP0A6Z3
PRIDEiP0A6Z3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73575; AAC73575; b0473
BAE76252; BAE76252; BAE76252
GeneIDi945099
KEGGiecj:JW0462
eco:b0473
PATRICifig|1411691.4.peg.1803

Organism-specific databases

EchoBASEiEB0456
EcoGeneiEG10461 htpG

Phylogenomic databases

eggNOGiENOG4105CJX Bacteria
COG0326 LUCA
HOGENOMiHOG000031989
InParanoidiP0A6Z3
KOiK04079
OMAiSDHEIFL
PhylomeDBiP0A6Z3

Enzyme and pathway databases

BioCyciEcoCyc:EG10461-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A6Z3
PROiPR:P0A6Z3

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHTPG_ECOLI
AccessioniPrimary (citable) accession number: P0A6Z3
Secondary accession number(s): P10413, Q2MBV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 10, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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