UniProtKB - P0A6Z3 (HTPG_ECOLI)
Protein
Chaperone protein HtpG
Gene
htpG
Organism
Escherichia coli (strain K12)
Status
Functioni
Molecular chaperone. Has ATPase activity.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | ATP1 Publication | 1 | |
Binding sitei | 80 | ATP1 Publication | 1 | |
Binding sitei | 127 | ATP; via amide nitrogen1 Publication | 1 | |
Binding sitei | 174 | ATP1 Publication | 1 | |
Binding sitei | 255 | ATP1 Publication | 1 |
GO - Molecular functioni
- ATPase activity Source: CACAO
- ATP binding Source: UniProtKB-UniRule
- chaperone binding Source: EcoCyc
- identical protein binding Source: IntAct
- protein folding chaperone Source: EcoCyc
- unfolded protein binding Source: GO_Central
GO - Biological processi
- ATP-dependent chaperone mediated protein folding Source: EcoCyc
- cellular response to DNA damage stimulus Source: EcoliWiki
- FtsZ-dependent cytokinesis Source: EcoCyc
- protein folding Source: EcoCyc
- response to heat Source: EcoliWiki
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10461-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Chaperone protein HtpGAlternative name(s): Heat shock protein C62.5 Heat shock protein HtpG High temperature protein G |
Gene namesi | Name:htpG Ordered Locus Names:b0473, JW0462 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: EcoCyc
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000062985 | 1 – 624 | Chaperone protein HtpGAdd BLAST | 624 |
Post-translational modificationi
Phosphorylated.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P0A6Z3 |
PaxDbi | P0A6Z3 |
PRIDEi | P0A6Z3 |
2D gel databases
SWISS-2DPAGEi | P0A6Z3 |
PTM databases
CarbonylDBi | P0A6Z3 |
Interactioni
Subunit structurei
Homodimer. Oligomerizes at 65 degrees Celsius.
3 PublicationsBinary interactionsi
Hide detailsP0A6Z3
With | #Exp. | IntAct |
---|---|---|
cdgI [P76236] | 3 | EBI-369221,EBI-552525 |
dnaK [P0A6Y8] | 3 | EBI-369221,EBI-542092 |
itself | 6 | EBI-369221,EBI-369221 |
rpoC [P0A8T7] | 3 | EBI-369221,EBI-543604 |
zapC [P75862] | 3 | EBI-369221,EBI-552519 |
GO - Molecular functioni
- chaperone binding Source: EcoCyc
- identical protein binding Source: IntAct
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 4261971, 211 interactors 849488, 3 interactors |
DIPi | DIP-29797N |
IntActi | P0A6Z3, 62 interactors |
STRINGi | 511145.b0473 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6Z3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A6Z3 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 336 | A; substrate-bindingAdd BLAST | 336 | |
Regioni | 337 – 552 | BAdd BLAST | 216 | |
Regioni | 553 – 624 | CAdd BLAST | 72 | |
Regioni | 585 – 624 | Mediates dimerizationAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the heat shock protein 90 family.Curated
Phylogenomic databases
eggNOGi | COG0326, Bacteria |
HOGENOMi | CLU_006684_3_0_6 |
InParanoidi | P0A6Z3 |
PhylomeDBi | P0A6Z3 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298, HSP90, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6Z3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKGQETRGFQ SEVKQLLHLM IHSLYSNKEI FLRELISNAS DAADKLRFRA
60 70 80 90 100
LSNPDLYEGD GELRVRVSFD KDKRTLTISD NGVGMTRDEV IDHLGTIAKS
110 120 130 140 150
GTKSFLESLG SDQAKDSQLI GQFGVGFYSA FIVADKVTVR TRAAGEKPEN
160 170 180 190 200
GVFWESAGEG EYTVADITKE DRGTEITLHL REGEDEFLDD WRVRSIISKY
210 220 230 240 250
SDHIALPVEI EKREEKDGET VISWEKINKA QALWTRNKSE ITDEEYKEFY
260 270 280 290 300
KHIAHDFNDP LTWSHNRVEG KQEYTSLLYI PSQAPWDMWN RDHKHGLKLY
310 320 330 340 350
VQRVFIMDDA EQFMPNYLRF VRGLIDSSDL PLNVSREILQ DSTVTRNLRN
360 370 380 390 400
ALTKRVLQML EKLAKDDAEK YQTFWQQFGL VLKEGPAEDF ANQEAIAKLL
410 420 430 440 450
RFASTHTDSS AQTVSLEDYV SRMKEGQEKI YYITADSYAA AKSSPHLELL
460 470 480 490 500
RKKGIEVLLL SDRIDEWMMN YLTEFDGKPF QSVSKVDESL EKLADEVDES
510 520 530 540 550
AKEAEKALTP FIDRVKALLG ERVKDVRLTH RLTDTPAIVS TDADEMSTQM
560 570 580 590 600
AKLFAAAGQK VPEVKYIFEL NPDHVLVKRA ADTEDEAKFS EWVELLLDQA
610 620
LLAERGTLED PNLFIRRMNQ LLVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38777 Genomic DNA Translation: AAA23460.1 U82664 Genomic DNA Translation: AAB40227.1 U00096 Genomic DNA Translation: AAC73575.1 AP009048 Genomic DNA Translation: BAE76252.1 |
PIRi | A28324, HHEC62 |
RefSeqi | NP_415006.1, NC_000913.3 WP_000678201.1, NZ_SSZK01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC73575; AAC73575; b0473 BAE76252; BAE76252; BAE76252 |
GeneIDi | 58348066 945099 |
KEGGi | ecj:JW0462 eco:b0473 |
PATRICi | fig|1411691.4.peg.1803 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38777 Genomic DNA Translation: AAA23460.1 U82664 Genomic DNA Translation: AAB40227.1 U00096 Genomic DNA Translation: AAC73575.1 AP009048 Genomic DNA Translation: BAE76252.1 |
PIRi | A28324, HHEC62 |
RefSeqi | NP_415006.1, NC_000913.3 WP_000678201.1, NZ_SSZK01000009.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SF8 | X-ray | 2.60 | A/B/C/D/E/F/G/H | 511-624 | [»] | |
1Y4S | X-ray | 2.90 | A/B | 1-559 | [»] | |
1Y4U | X-ray | 2.90 | A/B | 1-559 | [»] | |
2GQ0 | X-ray | 1.90 | A/B | 230-495 | [»] | |
2IOP | X-ray | 3.55 | A/B/C/D | 1-624 | [»] | |
2IOQ | X-ray | 3.50 | A/B | 1-624 | [»] | |
2IOR | X-ray | 1.65 | A | 1-215 | [»] | |
SMRi | P0A6Z3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261971, 211 interactors 849488, 3 interactors |
DIPi | DIP-29797N |
IntActi | P0A6Z3, 62 interactors |
STRINGi | 511145.b0473 |
PTM databases
CarbonylDBi | P0A6Z3 |
2D gel databases
SWISS-2DPAGEi | P0A6Z3 |
Proteomic databases
jPOSTi | P0A6Z3 |
PaxDbi | P0A6Z3 |
PRIDEi | P0A6Z3 |
Genome annotation databases
EnsemblBacteriai | AAC73575; AAC73575; b0473 BAE76252; BAE76252; BAE76252 |
GeneIDi | 58348066 945099 |
KEGGi | ecj:JW0462 eco:b0473 |
PATRICi | fig|1411691.4.peg.1803 |
Organism-specific databases
EchoBASEi | EB0456 |
Phylogenomic databases
eggNOGi | COG0326, Bacteria |
HOGENOMi | CLU_006684_3_0_6 |
InParanoidi | P0A6Z3 |
PhylomeDBi | P0A6Z3 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10461-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A6Z3 |
PHI-basei | PHI:6472 |
PROi | PR:P0A6Z3 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298, HSP90, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HTPG_ECOLI | |
Accessioni | P0A6Z3Primary (citable) accession number: P0A6Z3 Secondary accession number(s): P10413, Q2MBV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families