UniProtKB - P0A6Z0 (DNAK_ECO57)
Protein
Chaperone protein DnaK
Gene
dnaK
Organism
Escherichia coli O157:H7
Status
Functioni
Acts as a chaperone.By similarity
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ECOO157:DNAK-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Chaperone protein DnaKAlternative name(s): HSP70 Heat shock 70 kDa protein Heat shock protein 70 |
Gene namesi | Name:dnaK Ordered Locus Names:Z0014, ECs0014 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000078460 | 2 – 638 | Chaperone protein DnaKAdd BLAST | 637 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 109 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 199 | Phosphothreonine; by autocatalysisBy similarity | 1 | |
Modified residuei | 245 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 304 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 421 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 556 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PRIDEi | P0A6Z0 |
Expressioni
Inductioni
By stress conditions e.g. heat shock (By similarity).By similarity
Interactioni
GO - Molecular functioni
- unfolded protein binding Source: InterPro
Protein-protein interaction databases
STRINGi | 155864.Z0014 |
Structurei
3D structure databases
ProteinModelPortali | P0A6Z0 |
SMRi | P0A6Z0 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | ENOG4105CFG Bacteria COG0443 LUCA |
HOGENOMi | HOG000228136 |
KOi | K04043 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
HAMAPi | MF_00332 DnaK, 1 hit |
InterProi | View protein in InterPro IPR012725 Chaperone_DnaK IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam |
PANTHERi | PTHR19375 PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012 HSP70, 1 hit |
PRINTSi | PR00301 HEATSHOCK70 |
SUPFAMi | SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit |
TIGRFAMsi | TIGR02350 prok_dnaK, 1 hit |
PROSITEi | View protein in PROSITE PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A6Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKIIGIDLG TTNSCVAIMD GTTPRVLENA EGDRTTPSII AYTQDGETLV
60 70 80 90 100
GQPAKRQAVT NPQNTLFAIK RLIGRRFQDE EVQRDVSIMP FKIIAADNGD
110 120 130 140 150
AWVEVKGQKM APPQISAEVL KKMKKTAEDY LGEPVTEAVI TVPAYFNDAQ
160 170 180 190 200
RQATKDAGRI AGLEVKRIIN EPTAAALAYG LDKGTGNRTI AVYDLGGGTF
210 220 230 240 250
DISIIEIDEV DGEKTFEVLA TNGDTHLGGE DFDSRLINYL VEEFKKDQGI
260 270 280 290 300
DLRNDPLAMQ RLKEAAEKAK IELSSAQQTD VNLPYITADA TGPKHMNIKV
310 320 330 340 350
TRAKLESLVE DLVNRSIEPL KVALQDAGLS VSDIDDVILV GGQTRMPMVQ
360 370 380 390 400
KKVAEFFGKE PRKDVNPDEA VAIGAAVQGG VLTGDVKDVL LLDVTPLSLG
410 420 430 440 450
IETMGGVMTT LIAKNTTIPT KHSQVFSTAE DNQSAVTIHV LQGERKRAAD
460 470 480 490 500
NKSLGQFNLD GINPAPRGMP QIEVTFDIDA DGILHVSAKD KNSGKEQKIT
510 520 530 540 550
IKASSGLNED EIQKMVRDAE ANAEADRKFE ELVQTRNQGD HLLHSTRKQV
560 570 580 590 600
EEAGDKLPAD DKTAIESALT ALETALKGED KAAIEAKMQE LAQVSQKLME
610 620 630
IAQQQHAQQQ TAGADASANN AKDDDVVDAE FEEVKDKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG54314.1 BA000007 Genomic DNA Translation: BAB33437.1 |
PIRi | F85481 F90630 |
RefSeqi | NP_308041.1, NC_002695.1 WP_000516135.1, NZ_NOKN01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAG54314; AAG54314; Z0014 BAB33437; BAB33437; BAB33437 |
GeneIDi | 913406 |
KEGGi | ece:Z0014 ecs:ECs0014 |
PATRICi | fig|386585.9.peg.110 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG54314.1 BA000007 Genomic DNA Translation: BAB33437.1 |
PIRi | F85481 F90630 |
RefSeqi | NP_308041.1, NC_002695.1 WP_000516135.1, NZ_NOKN01000002.1 |
3D structure databases
ProteinModelPortali | P0A6Z0 |
SMRi | P0A6Z0 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 155864.Z0014 |
Proteomic databases
PRIDEi | P0A6Z0 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | AAG54314; AAG54314; Z0014 BAB33437; BAB33437; BAB33437 |
GeneIDi | 913406 |
KEGGi | ece:Z0014 ecs:ECs0014 |
PATRICi | fig|386585.9.peg.110 |
Phylogenomic databases
eggNOGi | ENOG4105CFG Bacteria COG0443 LUCA |
HOGENOMi | HOG000228136 |
KOi | K04043 |
Enzyme and pathway databases
BioCyci | ECOO157:DNAK-MONOMER |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
HAMAPi | MF_00332 DnaK, 1 hit |
InterProi | View protein in InterPro IPR012725 Chaperone_DnaK IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam |
PANTHERi | PTHR19375 PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012 HSP70, 1 hit |
PRINTSi | PR00301 HEATSHOCK70 |
SUPFAMi | SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit |
TIGRFAMsi | TIGR02350 prok_dnaK, 1 hit |
PROSITEi | View protein in PROSITE PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | DNAK_ECO57 | |
Accessioni | P0A6Z0Primary (citable) accession number: P0A6Z0 Secondary accession number(s): P04475 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 13, 2019 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families