UniProtKB - P0A6V8 (GLK_ECOLI)
Protein
Glucokinase
Gene
glk
Organism
Escherichia coli (strain K12)
Status
Functioni
Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.
Catalytic activityi
- EC:2.7.1.2
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 8 – 13 | ATPSequence analysis | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- glucokinase activity Source: EcoCyc
- glucose binding Source: InterPro
GO - Biological processi
- glycolytic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:GLUCOKIN-MONOMER MetaCyc:GLUCOKIN-MONOMER |
SABIO-RKi | P0A6V8 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:glk Ordered Locus Names:b2388, JW2385 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215124 | 1 – 321 | GlucokinaseAdd BLAST | 321 |
Proteomic databases
jPOSTi | P0A6V8 |
PaxDbi | P0A6V8 |
PRIDEi | P0A6V8 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260563, 10 interactors |
IntActi | P0A6V8, 5 interactors |
STRINGi | 511145.b2388 |
Family & Domainsi
Sequence similaritiesi
Belongs to the bacterial glucokinase family.Curated
Phylogenomic databases
eggNOGi | COG0837, Bacteria |
HOGENOMi | CLU_042582_1_0_6 |
InParanoidi | P0A6V8 |
PhylomeDBi | P0A6V8 |
Family and domain databases
HAMAPi | MF_00524, Glucokinase, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR003836, Glucokinase |
Pfami | View protein in Pfam PF02685, Glucokinase, 1 hit |
SUPFAMi | SSF53067, SSF53067, 1 hit |
TIGRFAMsi | TIGR00749, glk, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6V8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE
60 70 80 90 100
EHKVEVKDGC IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND
110 120 130 140 150
FTAVSMAIPM LKKEHLIQFG GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR
160 170 180 190 200
WVSLPGEGGH VDFAPNSEEE AIILEILRAE IGHVSAERVL SGPGLVNLYR
210 220 230 240 250
AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI MGRFGGNLAL
260 270 280 290 300
NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV
310 320
HDNPGLLGSG AHLRQTLGHI L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 108 | I → N in AAA64506 (PubMed:9023215).Curated | 1 | |
Sequence conflicti | 188 – 189 | RV → AC in AAA64506 (PubMed:9023215).Curated | 2 | |
Sequence conflicti | 274 | A → G in AAA64506 (PubMed:9023215).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U22490 Genomic DNA Translation: AAA64506.1 U00096 Genomic DNA Translation: AAC75447.1 AP009048 Genomic DNA Translation: BAA16258.1 |
PIRi | A65013 |
RefSeqi | NP_416889.1, NC_000913.3 WP_000170346.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75447; AAC75447; b2388 BAA16258; BAA16258; BAA16258 |
GeneIDi | 58350692 946858 |
KEGGi | ecj:JW2385 eco:b2388 |
PATRICi | fig|1411691.4.peg.4340 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U22490 Genomic DNA Translation: AAA64506.1 U00096 Genomic DNA Translation: AAC75447.1 AP009048 Genomic DNA Translation: BAA16258.1 |
PIRi | A65013 |
RefSeqi | NP_416889.1, NC_000913.3 WP_000170346.1, NZ_LN832404.1 |
3D structure databases
SMRi | P0A6V8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260563, 10 interactors |
IntActi | P0A6V8, 5 interactors |
STRINGi | 511145.b2388 |
Chemistry databases
DrugBanki | DB02379, Beta-D-Glucose |
Proteomic databases
jPOSTi | P0A6V8 |
PaxDbi | P0A6V8 |
PRIDEi | P0A6V8 |
Genome annotation databases
EnsemblBacteriai | AAC75447; AAC75447; b2388 BAA16258; BAA16258; BAA16258 |
GeneIDi | 58350692 946858 |
KEGGi | ecj:JW2385 eco:b2388 |
PATRICi | fig|1411691.4.peg.4340 |
Organism-specific databases
EchoBASEi | EB2791 |
Phylogenomic databases
eggNOGi | COG0837, Bacteria |
HOGENOMi | CLU_042582_1_0_6 |
InParanoidi | P0A6V8 |
PhylomeDBi | P0A6V8 |
Enzyme and pathway databases
BioCyci | EcoCyc:GLUCOKIN-MONOMER MetaCyc:GLUCOKIN-MONOMER |
SABIO-RKi | P0A6V8 |
Miscellaneous databases
PROi | PR:P0A6V8 |
Family and domain databases
HAMAPi | MF_00524, Glucokinase, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR003836, Glucokinase |
Pfami | View protein in Pfam PF02685, Glucokinase, 1 hit |
SUPFAMi | SSF53067, SSF53067, 1 hit |
TIGRFAMsi | TIGR00749, glk, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLK_ECOLI | |
Accessioni | P0A6V8Primary (citable) accession number: P0A6V8 Secondary accession number(s): P46880, P78276 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families