UniProtKB - P0A6U8 (GLGA_ECOLI)
Protein
Glycogen synthase
Gene
glgA
Organism
Escherichia coli (strain K12)
Status
Functioni
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
Catalytic activityi
- EC:2.4.1.21
: glycogen biosynthesis Pathwayi
This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 15 | ADP-glucose | 1 |
GO - Molecular functioni
- alpha-1,4-glucan synthase activity Source: UniProtKB-EC
- glycogen (starch) synthase activity Source: InterPro
- starch synthase activity Source: EcoCyc
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- glycogen biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Glycogen biosynthesis |
Enzyme and pathway databases
BioCyci | EcoCyc:GLYCOGENSYN-MONOMER MetaCyc:GLYCOGENSYN-MONOMER |
BRENDAi | 2.4.1.21, 2026 |
UniPathwayi | UPA00164 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycogen synthase (EC:2.4.1.21)Alternative name(s): Starch [bacterial glycogen] synthase |
Gene namesi | Name:glgA Ordered Locus Names:b3429, JW3392 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000188611 | 1 – 477 | Glycogen synthaseAdd BLAST | 477 |
Proteomic databases
jPOSTi | P0A6U8 |
PaxDbi | P0A6U8 |
PRIDEi | P0A6U8 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262501, 326 interactors |
IntActi | P0A6U8, 1 interactor |
STRINGi | 511145.b3429 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6U8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A6U8 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0297, Bacteria |
HOGENOMi | CLU_009583_18_2_6 |
InParanoidi | P0A6U8 |
PhylomeDBi | P0A6U8 |
Family and domain databases
HAMAPi | MF_00484, Glycogen_synth, 1 hit |
InterProi | View protein in InterPro IPR001296, Glyco_trans_1 IPR011835, GS/SS IPR013534, Starch_synth_cat_dom |
Pfami | View protein in Pfam PF08323, Glyco_transf_5, 1 hit PF00534, Glycos_transf_1, 1 hit |
TIGRFAMsi | TIGR02095, glgA, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6U8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVLHVCSEM FPLLKTGGLA DVIGALPAAQ IADGVDARVL LPAFPDIRRG
60 70 80 90 100
VTDAQVVSRR DTFAGHITLL FGHYNGVGIY LIDAPHLYDR PGSPYHDTNL
110 120 130 140 150
FAYTDNVLRF ALLGWVGAEM ASGLDPFWRP DVVHAHDWHA GLAPAYLAAR
160 170 180 190 200
GRPAKSVFTV HNLAYQGMFY AHHMNDIQLP WSFFNIHGLE FNGQISFLKA
210 220 230 240 250
GLYYADHITA VSPTYAREIT EPQFAYGMEG LLQQRHREGR LSGVLNGVDE
260 270 280 290 300
KIWSPETDLL LASRYTRDTL EDKAENKRQL QIAMGLKVDD KVPLFAVVSR
310 320 330 340 350
LTSQKGLDLV LEALPGLLEQ GGQLALLGAG DPVLQEGFLA AAAEYPGQVG
360 370 380 390 400
VQIGYHEAFS HRIMGGADVI LVPSRFEPCG LTQLYGLKYG TLPLVRRTGG
410 420 430 440 450
LADTVSDCSL ENLADGVASG FVFEDSNAWS LLRAIRRAFV LWSRPSLWRF
460 470
VQRQAMAMDF SWQVAAKSYR ELYYRLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | F → S in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 102 – 103 | AY → VH in AAA23870 (PubMed:3097003).Curated | 2 | |
Sequence conflicti | 245 | L → P in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 280 | L → S in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 286 | L → S in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 309 | L → S in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 314 | L → S in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 317 – 318 | LL → SS in AAA23870 (PubMed:3097003).Curated | 2 | |
Sequence conflicti | 387 | L → S in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 419 | S → N in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 422 | V → I in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 434 | A → T in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 444 | R → C (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 446 | S → P (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 461 | S → G in AAA23870 (PubMed:3097003).Curated | 1 | |
Sequence conflicti | 476 | L → S in AAA23870 (PubMed:3097003).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00281 Genomic DNA Translation: CAA23545.1 J02616 Genomic DNA Translation: AAA23870.1 U18997 Genomic DNA Translation: AAA58227.1 U00096 Genomic DNA Translation: AAC76454.1 AP009048 Genomic DNA Translation: BAE77863.1 J01616 Genomic DNA Translation: AAA98737.1 |
PIRi | H65138, SYECGL |
RefSeqi | NP_417887.1, NC_000913.3 WP_001197646.1, NZ_STEB01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC76454; AAC76454; b3429 BAE77863; BAE77863; BAE77863 |
GeneIDi | 49582609 947932 |
KEGGi | ecj:JW3392 eco:b3429 |
PATRICi | fig|1411691.4.peg.3299 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00281 Genomic DNA Translation: CAA23545.1 J02616 Genomic DNA Translation: AAA23870.1 U18997 Genomic DNA Translation: AAA58227.1 U00096 Genomic DNA Translation: AAC76454.1 AP009048 Genomic DNA Translation: BAE77863.1 J01616 Genomic DNA Translation: AAA98737.1 |
PIRi | H65138, SYECGL |
RefSeqi | NP_417887.1, NC_000913.3 WP_001197646.1, NZ_STEB01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QZS | X-ray | 2.20 | A | 1-477 | [»] | |
2R4T | X-ray | 2.26 | A | 1-477 | [»] | |
2R4U | X-ray | 2.37 | A | 1-477 | [»] | |
3COP | X-ray | 2.30 | A | 1-477 | [»] | |
3CX4 | X-ray | 2.29 | A | 1-477 | [»] | |
3D1J | X-ray | 3.00 | A | 1-477 | [»] | |
3GUH | X-ray | 2.79 | A | 1-477 | [»] | |
SMRi | P0A6U8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262501, 326 interactors |
IntActi | P0A6U8, 1 interactor |
STRINGi | 511145.b3429 |
Proteomic databases
jPOSTi | P0A6U8 |
PaxDbi | P0A6U8 |
PRIDEi | P0A6U8 |
Genome annotation databases
EnsemblBacteriai | AAC76454; AAC76454; b3429 BAE77863; BAE77863; BAE77863 |
GeneIDi | 49582609 947932 |
KEGGi | ecj:JW3392 eco:b3429 |
PATRICi | fig|1411691.4.peg.3299 |
Organism-specific databases
EchoBASEi | EB0372 |
Phylogenomic databases
eggNOGi | COG0297, Bacteria |
HOGENOMi | CLU_009583_18_2_6 |
InParanoidi | P0A6U8 |
PhylomeDBi | P0A6U8 |
Enzyme and pathway databases
UniPathwayi | UPA00164 |
BioCyci | EcoCyc:GLYCOGENSYN-MONOMER MetaCyc:GLYCOGENSYN-MONOMER |
BRENDAi | 2.4.1.21, 2026 |
Miscellaneous databases
EvolutionaryTracei | P0A6U8 |
PROi | PR:P0A6U8 |
Family and domain databases
HAMAPi | MF_00484, Glycogen_synth, 1 hit |
InterProi | View protein in InterPro IPR001296, Glyco_trans_1 IPR011835, GS/SS IPR013534, Starch_synth_cat_dom |
Pfami | View protein in Pfam PF08323, Glyco_transf_5, 1 hit PF00534, Glycos_transf_1, 1 hit |
TIGRFAMsi | TIGR02095, glgA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLGA_ECOLI | |
Accessioni | P0A6U8Primary (citable) accession number: P0A6U8 Secondary accession number(s): P08323, Q2M793 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | March 29, 2005 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families