UniProtKB - P0A6S5 (FTSB_ECOLI)
Protein
Cell division protein FtsB
Gene
ftsB
Organism
Escherichia coli (strain K12)
Status
Functioni
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.UniRule annotation2 Publications
Miscellaneous
The C-terminal domain of FtsB is degraded in the absence of either FtsL or FtsQ.
GO - Molecular functioni
- identical protein binding Source: EcoCyc
GO - Biological processi
- cell division Source: EcoliWiki
- FtsZ-dependent cytokinesis Source: EcoCyc
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | EcoCyc:G7424-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsBUniRule annotation |
Gene namesi | Name:ftsBUniRule annotation Synonyms:ygbQ Ordered Locus Names:b2748, JW2718 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation2 Publications; Single-pass type II membrane protein UniRule annotation2 Publications Note: Localizes to the division septum. Localization requires FtsQ and FtsL, but not FtsW and FtsI. Localization of FtsB and FtsL is codependent.
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | CytoplasmicUniRule annotation | 3 | |
Transmembranei | 4 – 21 | HelicalUniRule annotationAdd BLAST | 18 | |
Topological domaini | 22 – 103 | PeriplasmicUniRule annotationAdd BLAST | 82 |
GO - Cellular componenti
- cell division site Source: GO_Central
- cell septum Source: EcoliWiki
- integral component of plasma membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutants form long filaments, but DNA segregation is not affected.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214441 | 1 – 103 | Cell division protein FtsBAdd BLAST | 103 |
Proteomic databases
PaxDbi | P0A6S5 |
PRIDEi | P0A6S5 |
Interactioni
Subunit structurei
Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ.
Interacts also with FtsI and FtsN.
UniRule annotation4 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4262281, 273 interactors 850394, 2 interactors |
ComplexPortali | CPX-3099, FtsQBL complex CPX-3299, FtsBL complex |
DIPi | DIP-12117N |
IntActi | P0A6S5, 8 interactors |
STRINGi | 511145.b2748 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6S5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 31 – 71 | UniRule annotationAdd BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 41 – 72 | Leucine zipper-likeAdd BLAST | 32 |
Domaini
The transmembrane segment and the membrane-proximal periplasmic region, which forms a coiled-coil structure, are required for interaction with FtsL and recruitment of downstream division proteins. The C-terminal region is required for interaction with FtsQ, but is not required for recruitment of the downstream division protein FtsI. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsL.2 Publications
Sequence similaritiesi
Belongs to the FtsB family.UniRule annotation
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2919, Bacteria |
HOGENOMi | CLU_134863_5_2_6 |
InParanoidi | P0A6S5 |
PhylomeDBi | P0A6S5 |
Family and domain databases
HAMAPi | MF_00599, FtsB, 1 hit |
InterProi | View protein in InterPro IPR023081, Cell_div_FtsB IPR007060, FtsL/DivIC |
PANTHERi | PTHR37485, PTHR37485, 1 hit |
Pfami | View protein in Pfam PF04977, DivIC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6S5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKLTLLLLA ILVWLQYSLW FGKNGIHDYT RVNDDVAAQQ ATNAKLKARN
60 70 80 90 100
DQLFAEIDDL NGGQEALEER ARNELSMTRP GETFYRLVPD ASKRAQSAGQ
NNR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29579 Genomic DNA Translation: AAA69258.1 U00096 Genomic DNA Translation: AAC75790.1 AP009048 Genomic DNA Translation: BAE76825.1 |
PIRi | H65055 |
RefSeqi | NP_417228.1, NC_000913.3 WP_000517476.1, NZ_STEB01000027.1 |
Genome annotation databases
EnsemblBacteriai | AAC75790; AAC75790; b2748 BAE76825; BAE76825; BAE76825 |
GeneIDi | 48726429 946033 |
KEGGi | ecj:JW2718 eco:b2748 |
PATRICi | fig|1411691.4.peg.3992 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29579 Genomic DNA Translation: AAA69258.1 U00096 Genomic DNA Translation: AAC75790.1 AP009048 Genomic DNA Translation: BAE76825.1 |
PIRi | H65055 |
RefSeqi | NP_417228.1, NC_000913.3 WP_000517476.1, NZ_STEB01000027.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4IFF | X-ray | 2.30 | A/B/C/D | 28-63 | [»] | |
5Z2W | X-ray | 3.00 | B | 61-95 | [»] | |
SMRi | P0A6S5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262281, 273 interactors 850394, 2 interactors |
ComplexPortali | CPX-3099, FtsQBL complex CPX-3299, FtsBL complex |
DIPi | DIP-12117N |
IntActi | P0A6S5, 8 interactors |
STRINGi | 511145.b2748 |
Proteomic databases
PaxDbi | P0A6S5 |
PRIDEi | P0A6S5 |
Genome annotation databases
EnsemblBacteriai | AAC75790; AAC75790; b2748 BAE76825; BAE76825; BAE76825 |
GeneIDi | 48726429 946033 |
KEGGi | ecj:JW2718 eco:b2748 |
PATRICi | fig|1411691.4.peg.3992 |
Organism-specific databases
EchoBASEi | EB2914 |
Phylogenomic databases
eggNOGi | COG2919, Bacteria |
HOGENOMi | CLU_134863_5_2_6 |
InParanoidi | P0A6S5 |
PhylomeDBi | P0A6S5 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7424-MONOMER |
Miscellaneous databases
PROi | PR:P0A6S5 |
Family and domain databases
HAMAPi | MF_00599, FtsB, 1 hit |
InterProi | View protein in InterPro IPR023081, Cell_div_FtsB IPR007060, FtsL/DivIC |
PANTHERi | PTHR37485, PTHR37485, 1 hit |
Pfami | View protein in Pfam PF04977, DivIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSB_ECOLI | |
Accessioni | P0A6S5Primary (citable) accession number: P0A6S5 Secondary accession number(s): Q2MA81, Q46894 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families