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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.2 Publications

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:FABZ-MONOMER
MetaCyc:FABZ-MONOMER

Chemistry databases

SwissLipidsiSLP:000001787

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC:4.2.1.59)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name:
(3R)-hydroxymyristoyl-ACP dehydrase
17 kDa actomyosin component
Beta-hydroxyacyl-ACP dehydratase
Gene namesi
Name:fabZ
Synonyms:sefA, yaeA
Ordered Locus Names:b0180, JW0175
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11284 fabZ

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85L → P in sfhC21; suppresses an ftsH deletion mutant as well as an ftsH temperature-sensitive mutation. Probably stabilizes the enzyme. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000916731 – 1513-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST151

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiP0A6Q6
PaxDbiP0A6Q6
PRIDEiP0A6Q6

Interactioni

Subunit structurei

Oligomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4263243, 437 interactors
DIPiDIP-31868N
IntActiP0A6Q6, 34 interactors
STRINGi316385.ECDH10B_0160

Structurei

3D structure databases

ProteinModelPortaliP0A6Q6
SMRiP0A6Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108YXN Bacteria
COG0764 LUCA
HOGENOMiHOG000277829
InParanoidiP0A6Q6
KOiK02372
OMAiFPGRPLM
PhylomeDBiP0A6Q6

Family and domain databases

HAMAPiMF_00406 FabZ, 1 hit
InterProiView protein in InterPro
IPR013114 FabA_FabZ
IPR010084 FabZ
IPR029069 HotDog_dom_sf
PfamiView protein in Pfam
PF07977 FabA, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR01750 fabZ, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF
60 70 80 90 100
FQGHFPGKPI FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR
110 120 130 140 150
FKRPVVPGDQ MIMEVTFEKT RRGLTRFKGV ALVDGKVVCE ATMMCARSRE

A
Length:151
Mass (Da):17,033
Last modified:May 10, 2005 - v1
Checksum:i91F514A7319C2FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19334 Genomic DNA Translation: AAC36917.1
U00096 Genomic DNA Translation: AAC73291.1
AP009048 Genomic DNA Translation: BAA77855.1
U70214 Genomic DNA Translation: AAB08609.1
PIRiD64742
RefSeqiNP_414722.1, NC_000913.3
WP_000210739.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73291; AAC73291; b0180
BAA77855; BAA77855; BAA77855
GeneIDi944888
KEGGiecj:JW0175
eco:b0180
PATRICifig|1411691.4.peg.2099

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19334 Genomic DNA Translation: AAC36917.1
U00096 Genomic DNA Translation: AAC73291.1
AP009048 Genomic DNA Translation: BAA77855.1
U70214 Genomic DNA Translation: AAB08609.1
PIRiD64742
RefSeqiNP_414722.1, NC_000913.3
WP_000210739.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0A6Q6
SMRiP0A6Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263243, 437 interactors
DIPiDIP-31868N
IntActiP0A6Q6, 34 interactors
STRINGi316385.ECDH10B_0160

Chemistry databases

SwissLipidsiSLP:000001787

Proteomic databases

EPDiP0A6Q6
PaxDbiP0A6Q6
PRIDEiP0A6Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73291; AAC73291; b0180
BAA77855; BAA77855; BAA77855
GeneIDi944888
KEGGiecj:JW0175
eco:b0180
PATRICifig|1411691.4.peg.2099

Organism-specific databases

EchoBASEiEB1261
EcoGeneiEG11284 fabZ

Phylogenomic databases

eggNOGiENOG4108YXN Bacteria
COG0764 LUCA
HOGENOMiHOG000277829
InParanoidiP0A6Q6
KOiK02372
OMAiFPGRPLM
PhylomeDBiP0A6Q6

Enzyme and pathway databases

BioCyciEcoCyc:FABZ-MONOMER
MetaCyc:FABZ-MONOMER

Miscellaneous databases

PROiPR:P0A6Q6

Family and domain databases

HAMAPiMF_00406 FabZ, 1 hit
InterProiView protein in InterPro
IPR013114 FabA_FabZ
IPR010084 FabZ
IPR029069 HotDog_dom_sf
PfamiView protein in Pfam
PF07977 FabA, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR01750 fabZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABZ_ECOLI
AccessioniPrimary (citable) accession number: P0A6Q6
Secondary accession number(s): P21774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 10, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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