fabZ

Functionⁱ

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.2 Publications

Catalytic activityⁱ

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H₂O.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	54	By similarity		1

GO - Molecular functionⁱ

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 8910376
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 8910376
identical protein binding
Source: EcoCyc
Inferred from direct assayⁱ
- 7806516

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid biosynthetic process
Source: EcoCyc
Inferred from direct assayⁱ
- 8910376
lipid A biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCycⁱ	EcoCyc:FABZ-MONOMER MetaCyc:FABZ-MONOMER

BioCycⁱ

EcoCyc:FABZ-MONOMER
MetaCyc:FABZ-MONOMER

Chemistry databases

SwissLipidsⁱ	SLP:000001787

SwissLipidsⁱ

SLP:000001787

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC:4.2.1.59) Alternative name(s): (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase Short name: (3R)-hydroxymyristoyl-ACP dehydrase 17 kDa actomyosin component Beta-hydroxyacyl-ACP dehydratase
Gene namesⁱ	Name:fabZ Synonyms:sefA, yaeA Ordered Locus Names:b0180, JW0175
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11284 fabZ

EcoGeneⁱ

EG11284 fabZ

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	85	L → P in sfhC21; suppresses an ftsH deletion mutant as well as an ftsH temperature-sensitive mutation. Probably stabilizes the enzyme. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091673	1 – 151	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST		151

Post-translational modificationⁱ

The N-terminus is blocked.

Proteomic databases

EPDⁱ	P0A6Q6
PaxDbⁱ	P0A6Q6
PRIDEⁱ	P0A6Q6

Interactionⁱ

Subunit structureⁱ

Oligomer.

GO - Molecular functionⁱ

identical protein binding
Source: EcoCyc
Inferred from direct assayⁱ
- 7806516

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	4263243, 437 interactors
Database of interacting proteins More...DIPⁱ	DIP-31868N
IntActⁱ	P0A6Q6, 34 interactors
STRINGⁱ	316385.ECDH10B_0160

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0A6Q6
SMRⁱ	P0A6Q6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thioester dehydratase family. FabZ subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4108YXN Bacteria COG0764 LUCA
HOGENOMⁱ	HOG000277829
InParanoidⁱ	P0A6Q6
KEGG Orthology (KO) More...KOⁱ	K02372
OMAⁱ	FPGRPLM
PhylomeDBⁱ	P0A6Q6

Family and domain databases

HAMAPⁱ	MF_00406 FabZ, 1 hit
InterProⁱ	View protein in InterPro IPR013114 FabA_FabZ IPR010084 FabZ IPR029069 HotDog_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07977 FabA, 1 hit
SUPFAMⁱ	SSF54637 SSF54637, 1 hit
TIGRFAMsⁱ	TIGR01750 fabZ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0A6Q6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF 
        60         70         80         90        100
FQGHFPGKPI FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR 
       110        120        130        140        150
FKRPVVPGDQ MIMEVTFEKT RRGLTRFKGV ALVDGKVVCE ATMMCARSRE 

A

Length:151

Mass (Da):17,033

Last modified:May 10, 2005 - v1

Checksum:ⁱ91F514A7319C2FB1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19334 Genomic DNA Translation: AAC36917.1 U00096 Genomic DNA Translation: AAC73291.1 AP009048 Genomic DNA Translation: BAA77855.1 U70214 Genomic DNA Translation: AAB08609.1
PIRⁱ	D64742
NCBI Reference Sequences More...RefSeqⁱ	NP_414722.1, NC_000913.3 WP_000210739.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73291; AAC73291; b0180 BAA77855; BAA77855; BAA77855
GeneIDⁱ	944888
KEGGⁱ	ecj:JW0175 eco:b0180
PATRICⁱ	fig\|1411691.4.peg.2099

Protein	Similar proteins		Species	Score	Length
P0A6Q6	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		ECO24		151
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		ECO27		151
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		ECO45		151
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		ECO55		151
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		ECO57		151
+635

Protein	Similar proteins		Species	Score	Length
P0A6Q6	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		ECOHS		151
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		SERP5		176
UPI0008FBE9C8		Serratia		162
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ		Serratia sp. MYb239		175
UPI000BFF6FB2		SERRU		162
+974

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19334 Genomic DNA Translation: AAC36917.1 U00096 Genomic DNA Translation: AAC73291.1 AP009048 Genomic DNA Translation: BAA77855.1 U70214 Genomic DNA Translation: AAB08609.1
PIRⁱ	D64742
NCBI Reference Sequences More...RefSeqⁱ	NP_414722.1, NC_000913.3 WP_000210739.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0A6Q6
SMRⁱ	P0A6Q6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4263243, 437 interactors
Database of interacting proteins More...DIPⁱ	DIP-31868N
IntActⁱ	P0A6Q6, 34 interactors
STRINGⁱ	316385.ECDH10B_0160

Chemistry databases

SwissLipidsⁱ	SLP:000001787

SwissLipidsⁱ

SLP:000001787

Proteomic databases

EPDⁱ	P0A6Q6
PaxDbⁱ	P0A6Q6
PRIDEⁱ	P0A6Q6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73291; AAC73291; b0180 BAA77855; BAA77855; BAA77855
GeneIDⁱ	944888
KEGGⁱ	ecj:JW0175 eco:b0180
PATRICⁱ	fig\|1411691.4.peg.2099

Organism-specific databases

EchoBASEⁱ	EB1261
EcoGeneⁱ	EG11284 fabZ

Phylogenomic databases

eggNOGⁱ	ENOG4108YXN Bacteria COG0764 LUCA
HOGENOMⁱ	HOG000277829
InParanoidⁱ	P0A6Q6
KEGG Orthology (KO) More...KOⁱ	K02372
OMAⁱ	FPGRPLM
PhylomeDBⁱ	P0A6Q6

Enzyme and pathway databases

BioCycⁱ	EcoCyc:FABZ-MONOMER MetaCyc:FABZ-MONOMER

BioCycⁱ

EcoCyc:FABZ-MONOMER
MetaCyc:FABZ-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0A6Q6

PROⁱ

PR:P0A6Q6

Family and domain databases

HAMAPⁱ	MF_00406 FabZ, 1 hit
InterProⁱ	View protein in InterPro IPR013114 FabA_FabZ IPR010084 FabZ IPR029069 HotDog_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07977 FabA, 1 hit
SUPFAMⁱ	SSF54637 SSF54637, 1 hit
TIGRFAMsⁱ	TIGR01750 fabZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FABZ_ECOLI
Accessionⁱ	P0A6Q6Primary (citable) accession number: P0A6Q6 Secondary accession number(s): P21774
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	March 28, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A6Q6 (FABZ_ECOLI)

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3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ