We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P0A6Q6 (FABZ_ECOLI)
Protein
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Gene
fabZ
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
3 PublicationsCatalytic activityi
- EC:4.2.1.593 PublicationsThis reaction proceeds in the forward3 Publications direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 54 | By similarity | 1 |
GO - Molecular functioni
- (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Source: EcoCyc
- 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: EcoCyc
- 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
- identical protein binding Source: EcoCyc
GO - Biological processi
- fatty acid biosynthetic process Source: EcoCyc
- lipid A biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Biological process | Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:FABZ-MONOMER |
Chemistry databases
SwissLipidsi | SLP:000001787 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC:4.2.1.593 Publications)Alternative name(s): (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase Short name: (3R)-hydroxymyristoyl-ACP dehydrase 17 kDa actomyosin component Beta-hydroxyacyl-ACP dehydratase |
Gene namesi | Name:fabZ Synonyms:sefA, yaeA Ordered Locus Names:b0180, JW0175 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 85 | L → P in sfhC21; suppresses an ftsH deletion mutant as well as an ftsH temperature-sensitive mutation. Probably stabilizes the enzyme. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091673 | 1 – 151 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST | 151 |
Post-translational modificationi
The N-terminus is blocked.
Proteomic databases
jPOSTi | P0A6Q6 |
PaxDbi | P0A6Q6 |
PRIDEi | P0A6Q6 |
Interactioni
Subunit structurei
Oligomer.
GO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4263243, 437 interactors |
DIPi | DIP-31868N |
IntActi | P0A6Q6, 34 interactors |
STRINGi | 511145.b0180 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6Q6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0764, Bacteria |
HOGENOMi | CLU_078912_1_0_6 |
InParanoidi | P0A6Q6 |
PhylomeDBi | P0A6Q6 |
Family and domain databases
HAMAPi | MF_00406, FabZ, 1 hit |
InterProi | View protein in InterPro IPR013114, FabA_FabZ IPR010084, FabZ IPR029069, HotDog_dom_sf |
PANTHERi | PTHR30272, PTHR30272, 1 hit |
Pfami | View protein in Pfam PF07977, FabA, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit |
TIGRFAMsi | TIGR01750, fabZ, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF
60 70 80 90 100
FQGHFPGKPI FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR
110 120 130 140 150
FKRPVVPGDQ MIMEVTFEKT RRGLTRFKGV ALVDGKVVCE ATMMCARSRE
A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19334 Genomic DNA Translation: AAC36917.1 U00096 Genomic DNA Translation: AAC73291.1 AP009048 Genomic DNA Translation: BAA77855.1 U70214 Genomic DNA Translation: AAB08609.1 |
PIRi | D64742 |
RefSeqi | NP_414722.1, NC_000913.3 WP_000210739.1, NZ_STEB01000032.1 |
Genome annotation databases
EnsemblBacteriai | AAC73291; AAC73291; b0180 BAA77855; BAA77855; BAA77855 |
GeneIDi | 67416256 944888 |
KEGGi | ecj:JW0175 eco:b0180 |
PATRICi | fig|1411691.4.peg.2099 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19334 Genomic DNA Translation: AAC36917.1 U00096 Genomic DNA Translation: AAC73291.1 AP009048 Genomic DNA Translation: BAA77855.1 U70214 Genomic DNA Translation: AAB08609.1 |
PIRi | D64742 |
RefSeqi | NP_414722.1, NC_000913.3 WP_000210739.1, NZ_STEB01000032.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6N3P | X-ray | 2.50 | A/B/C/D/E/F | 1-150 | [»] | |
SMRi | P0A6Q6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263243, 437 interactors |
DIPi | DIP-31868N |
IntActi | P0A6Q6, 34 interactors |
STRINGi | 511145.b0180 |
Chemistry databases
SwissLipidsi | SLP:000001787 |
Proteomic databases
jPOSTi | P0A6Q6 |
PaxDbi | P0A6Q6 |
PRIDEi | P0A6Q6 |
Genome annotation databases
EnsemblBacteriai | AAC73291; AAC73291; b0180 BAA77855; BAA77855; BAA77855 |
GeneIDi | 67416256 944888 |
KEGGi | ecj:JW0175 eco:b0180 |
PATRICi | fig|1411691.4.peg.2099 |
Organism-specific databases
EchoBASEi | EB1261 |
Phylogenomic databases
eggNOGi | COG0764, Bacteria |
HOGENOMi | CLU_078912_1_0_6 |
InParanoidi | P0A6Q6 |
PhylomeDBi | P0A6Q6 |
Enzyme and pathway databases
BioCyci | EcoCyc:FABZ-MONOMER |
Miscellaneous databases
PROi | PR:P0A6Q6 |
Family and domain databases
HAMAPi | MF_00406, FabZ, 1 hit |
InterProi | View protein in InterPro IPR013114, FabA_FabZ IPR010084, FabZ IPR029069, HotDog_dom_sf |
PANTHERi | PTHR30272, PTHR30272, 1 hit |
Pfami | View protein in Pfam PF07977, FabA, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit |
TIGRFAMsi | TIGR01750, fabZ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABZ_ECOLI | |
Accessioni | P0A6Q6Primary (citable) accession number: P0A6Q6 Secondary accession number(s): P21774 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families