UniProtKB - P0A6P7 (ENGB_ECOLI)
Protein
Probable GTP-binding protein EngB
Gene
engB
Organism
Escherichia coli (strain K12)
Status
Functioni
Necessary for normal cell division and for the maintenance of normal septation. Depletion of this protein leads to a severe reduction in growth rate and to extensive filamentation, with a block beyond the stage of segregation. Essential for bacteria survival.UniRule annotation1 Publication
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 40 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 62 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 40 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 60 – 64 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 78 – 81 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 145 – 148 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 178 – 180 | GTPUniRule annotation | 3 |
GO - Molecular functioni
- GTP binding Source: EcoCyc
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- division septum assembly Source: UniProtKB-KW
Keywordsi
Biological process | Cell cycle, Cell division, Septation |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11203-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable GTP-binding protein EngBUniRule annotation |
Gene namesi | Name:engBUniRule annotation Synonyms:yihA Ordered Locus Names:b3865, JW5930 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157747 | 1 – 210 | Probable GTP-binding protein EngBAdd BLAST | 210 |
Proteomic databases
jPOSTi | P0A6P7 |
PaxDbi | P0A6P7 |
PRIDEi | P0A6P7 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262625, 413 interactors |
DIPi | DIP-48178N |
STRINGi | 511145.b3865 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6P7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A6P7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 199 | EngB-type GUniRule annotationAdd BLAST | 175 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0218, Bacteria |
HOGENOMi | CLU_033732_1_0_6 |
InParanoidi | P0A6P7 |
PhylomeDBi | P0A6P7 |
Family and domain databases
CDDi | cd01876, YihA_EngB, 1 hit |
HAMAPi | MF_00321, GTPase_EngB, 1 hit |
InterProi | View protein in InterPro IPR030393, G_ENGB_dom IPR019987, GTP-bd_ribosome_bio_YsxC IPR006073, GTP_binding_domain IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03598, GTPase_YsxC, 1 hit |
PROSITEi | View protein in PROSITE PS51706, G_ENGB, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6P7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNLNYQQTH FVMSAPDIRH LPSDTGIEVA FAGRSNAGKS SALNTLTNQK
60 70 80 90 100
SLARTSKTPG RTQLINLFEV ADGKRLVDLP GYGYAEVPEE MKRKWQRALG
110 120 130 140 150
EYLEKRQSLQ GLVVLMDIRH PLKDLDQQMI EWAVDSNIAV LVLLTKADKL
160 170 180 190 200
ASGARKAQLN MVREAVLAFN GDVQVETFSS LKKQGVDKLR QKLDTWFSEM
210
QPVEETQDGE
Sequence cautioni
The sequence AAA24403 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB02999 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE77444 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01663 Genomic DNA Translation: AAA24403.1 Different initiation. L19201 Genomic DNA Translation: AAB02999.1 Different initiation. U00096 Genomic DNA Translation: AAC76862.3 AP009048 Genomic DNA Translation: BAE77444.1 Different initiation. |
PIRi | S40810 |
RefSeqi | NP_418301.3, NC_000913.3 WP_000183349.1, NZ_STEB01000017.1 |
Genome annotation databases
EnsemblBacteriai | AAC76862; AAC76862; b3865 BAE77444; BAE77444; BAE77444 |
GeneIDi | 49586851 948358 |
KEGGi | ecj:JW5930 eco:b3865 |
PATRICi | fig|1411691.4.peg.2848 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01663 Genomic DNA Translation: AAA24403.1 Different initiation. L19201 Genomic DNA Translation: AAB02999.1 Different initiation. U00096 Genomic DNA Translation: AAC76862.3 AP009048 Genomic DNA Translation: BAE77444.1 Different initiation. |
PIRi | S40810 |
RefSeqi | NP_418301.3, NC_000913.3 WP_000183349.1, NZ_STEB01000017.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PUI | X-ray | 2.00 | A/B | 1-210 | [»] | |
SMRi | P0A6P7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262625, 413 interactors |
DIPi | DIP-48178N |
STRINGi | 511145.b3865 |
Proteomic databases
jPOSTi | P0A6P7 |
PaxDbi | P0A6P7 |
PRIDEi | P0A6P7 |
Genome annotation databases
EnsemblBacteriai | AAC76862; AAC76862; b3865 BAE77444; BAE77444; BAE77444 |
GeneIDi | 49586851 948358 |
KEGGi | ecj:JW5930 eco:b3865 |
PATRICi | fig|1411691.4.peg.2848 |
Organism-specific databases
EchoBASEi | EB1188 |
Phylogenomic databases
eggNOGi | COG0218, Bacteria |
HOGENOMi | CLU_033732_1_0_6 |
InParanoidi | P0A6P7 |
PhylomeDBi | P0A6P7 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11203-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A6P7 |
PROi | PR:P0A6P7 |
Family and domain databases
CDDi | cd01876, YihA_EngB, 1 hit |
HAMAPi | MF_00321, GTPase_EngB, 1 hit |
InterProi | View protein in InterPro IPR030393, G_ENGB_dom IPR019987, GTP-bd_ribosome_bio_YsxC IPR006073, GTP_binding_domain IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03598, GTPase_YsxC, 1 hit |
PROSITEi | View protein in PROSITE PS51706, G_ENGB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENGB_ECOLI | |
Accessioni | P0A6P7Primary (citable) accession number: P0A6P7 Secondary accession number(s): P24253, P76771, Q2M8G2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families