UniProtKB - P0A6L7 (UXAB_ECOLI)
Protein
Altronate oxidoreductase
Gene
uxaB
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:1.1.1.58
: pentose and glucuronate interconversion Pathwayi
This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 29 | NADBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- mannitol-1-phosphate 5-dehydrogenase activity Source: GO_Central
- tagaturonate reductase activity Source: EcoCyc
GO - Biological processi
- D-galacturonate catabolic process Source: EcoCyc
- mannitol catabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:ALTRO-OXIDOREDUCT-MONOMER MetaCyc:ALTRO-OXIDOREDUCT-MONOMER |
UniPathwayi | UPA00246 |
Names & Taxonomyi
Protein namesi | Recommended name: Altronate oxidoreductase (EC:1.1.1.58)Alternative name(s): Tagaturonate dehydrogenase Tagaturonate reductase |
Gene namesi | Name:uxaB Ordered Locus Names:b1521, JW1514 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000170742 | 1 – 483 | Altronate oxidoreductaseAdd BLAST | 483 |
Proteomic databases
jPOSTi | P0A6L7 |
PaxDbi | P0A6L7 |
PRIDEi | P0A6L7 |
Expressioni
Inductioni
By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose.
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260230, 7 interactors |
IntActi | P0A6L7, 7 interactors |
STRINGi | 511145.b1521 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0246, Bacteria |
HOGENOMi | CLU_027324_1_0_6 |
InParanoidi | P0A6L7 |
PhylomeDBi | P0A6L7 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
HAMAPi | MF_00670, Altron_oxidoreduct, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR023668, Altronate_OxRdtase IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6L7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV
60 70 80 90 100
VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS
110 120 130 140 150
EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL
160 170 180 190 200
FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW
210 220 230 240 250
LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT AEHFYLFVIQ
260 270 280 290 300
GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG
310 320 330 340 350
LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP
360 370 380 390 400
YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY
410 420 430 440 450
RGERNGETYP VQDDAHWLER YQQLWSQHRD RVIGTQELVA IVLAEKDHWE
460 470 480
QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13327 Genomic DNA Translation: BAA02586.1 U00096 Genomic DNA Translation: AAT48131.1 AP009048 Genomic DNA Translation: BAA15204.1 M15737 Genomic DNA Translation: AAA24757.1 |
PIRi | D64906 |
RefSeqi | WP_000854633.1, NZ_SSZK01000001.1 YP_025302.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48131; AAT48131; b1521 BAA15204; BAA15204; BAA15204 |
GeneIDi | 57730489 945542 |
KEGGi | ecj:JW1514 eco:b1521 |
PATRICi | fig|1411691.4.peg.746 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13327 Genomic DNA Translation: BAA02586.1 U00096 Genomic DNA Translation: AAT48131.1 AP009048 Genomic DNA Translation: BAA15204.1 M15737 Genomic DNA Translation: AAA24757.1 |
PIRi | D64906 |
RefSeqi | WP_000854633.1, NZ_SSZK01000001.1 YP_025302.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260230, 7 interactors |
IntActi | P0A6L7, 7 interactors |
STRINGi | 511145.b1521 |
Proteomic databases
jPOSTi | P0A6L7 |
PaxDbi | P0A6L7 |
PRIDEi | P0A6L7 |
Genome annotation databases
EnsemblBacteriai | AAT48131; AAT48131; b1521 BAA15204; BAA15204; BAA15204 |
GeneIDi | 57730489 945542 |
KEGGi | ecj:JW1514 eco:b1521 |
PATRICi | fig|1411691.4.peg.746 |
Organism-specific databases
EchoBASEi | EB1058 |
Phylogenomic databases
eggNOGi | COG0246, Bacteria |
HOGENOMi | CLU_027324_1_0_6 |
InParanoidi | P0A6L7 |
PhylomeDBi | P0A6L7 |
Enzyme and pathway databases
UniPathwayi | UPA00246 |
BioCyci | EcoCyc:ALTRO-OXIDOREDUCT-MONOMER MetaCyc:ALTRO-OXIDOREDUCT-MONOMER |
Miscellaneous databases
PROi | PR:P0A6L7 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
HAMAPi | MF_00670, Altron_oxidoreduct, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR023668, Altronate_OxRdtase IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UXAB_ECOLI | |
Accessioni | P0A6L7Primary (citable) accession number: P0A6L7 Secondary accession number(s): P24214, P78064 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families