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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 29NADBy similarityAdd BLAST12

GO - Molecular functioni

  • NAD binding Source: EcoCyc
  • tagaturonate reductase activity Source: UniProtKB-EC

GO - Biological processi

  • D-galacturonate catabolic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:ALTRO-OXIDOREDUCT-MONOMER
MetaCyc:ALTRO-OXIDOREDUCT-MONOMER
UniPathwayiUPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductase (EC:1.1.1.58)
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene namesi
Name:uxaB
Ordered Locus Names:b1521, JW1514
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11065 uxaB

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707421 – 483Altronate oxidoreductaseAdd BLAST483

Proteomic databases

PaxDbiP0A6L7
PRIDEiP0A6L7

Expressioni

Inductioni

By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose.

Interactioni

Protein-protein interaction databases

BioGridi4260230, 7 interactors
IntActiP0A6L7, 7 interactors
STRINGi316407.1742495

Structurei

3D structure databases

ProteinModelPortaliP0A6L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QZW Bacteria
COG0246 LUCA
HOGENOMiHOG000029586
InParanoidiP0A6L7
KOiK00041
OMAiVVIVRPI
PhylomeDBiP0A6L7

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00670 Altron_oxidoreduct, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR023668 Altronate_OxRdtase
IPR013118 Mannitol_DH_C
IPR013131 Mannitol_DH_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01232 Mannitol_dh, 1 hit
PF08125 Mannitol_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV
60 70 80 90 100
VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS
110 120 130 140 150
EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL
160 170 180 190 200
FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW
210 220 230 240 250
LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT AEHFYLFVIQ
260 270 280 290 300
GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG
310 320 330 340 350
LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP
360 370 380 390 400
YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY
410 420 430 440 450
RGERNGETYP VQDDAHWLER YQQLWSQHRD RVIGTQELVA IVLAEKDHWE
460 470 480
QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC
Length:483
Mass (Da):54,808
Last modified:May 10, 2005 - v1
Checksum:iAFA4677CF35BC2E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13327 Genomic DNA Translation: BAA02586.1
U00096 Genomic DNA Translation: AAT48131.1
AP009048 Genomic DNA Translation: BAA15204.1
M15737 Genomic DNA Translation: AAA24757.1
PIRiD64906
RefSeqiWP_000854633.1, NZ_LN832404.1
YP_025302.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48131; AAT48131; b1521
BAA15204; BAA15204; BAA15204
GeneIDi945542
KEGGiecj:JW1514
eco:b1521
PATRICifig|1411691.4.peg.746

Similar proteinsi

Entry informationi

Entry nameiUXAB_ECOLI
AccessioniPrimary (citable) accession number: P0A6L7
Secondary accession number(s): P24214, P78064
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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