Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P0A6K6 (DEOB_ECOLI)

Protein

Phosphopentomutase

Gene

deoB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+CuratedNote: Binds 1 or 2 manganese ions.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi10ManganeseBy similarity1
Metal bindingi311ManganeseBy similarity1
Metal bindingi347ManganeseBy similarity1
Metal bindingi348ManganeseBy similarity1
Metal bindingi359ManganeseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • manganese ion binding Source: UniProtKB-UniRule
  • phosphopentomutase activity Source: EcoCyc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  • cellular metabolic compound salvage Source: InterPro
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • deoxyribonucleotide catabolic process Source: EcoCyc
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PPENTOMUT-MONOMER
MetaCyc:PPENTOMUT-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.4.2.7 2026

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00087;UER00173

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphopentomutase (EC:5.4.2.7)
Alternative name(s):
Phosphodeoxyribomutase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:deoB
Synonyms:drm, thyR
Ordered Locus Names:b4383, JW4346
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...EcoGenei		EG10220 deoB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001998191 – 407PhosphopentomutaseAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei287N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P0A6K6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0A6K6

PRoteomics IDEntifications database

More...PRIDEi		P0A6K6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0A6K6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4263160, 14 interactors

Database of interacting proteins

More...DIPi		DIP-48057N

Protein interaction database and analysis system

More...IntActi		P0A6K6, 6 interactors

STRING: functional protein association networks

More...STRINGi		316385.ECDH10B_4541

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P0A6K6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0A6K6

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphopentomutase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105CZG Bacteria
COG1015 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000008159

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0A6K6

KEGG Orthology (KO)

More...KOi		K01839

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0A6K6

Family and domain databases

Conserved Domains Database

More...CDDi		cd16009 PPM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.1250, 1 hit
3.40.720.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00740 Phosphopentomut, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR010045 DeoB
IPR006124 Metalloenzyme
IPR024052 Phosphopentomutase_DeoB_cap_sf

The PANTHER Classification System

More...PANTHERi		PTHR21110 PTHR21110, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01676 Metalloenzyme, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001491 Ppentomutase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143856 SSF143856, 1 hit
SSF53649 SSF53649, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01696 deoB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A6K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRAFIMVLD SFGIGATEDA ERFGDVGADT LGHIAEACAK GEADNGRKGP 
        60         70         80         90        100
LNLPNLTRLG LAKAHEGSTG FIPAGMDGNA EVIGAYAWAH EMSSGKDTPS 
       110        120        130        140        150
GHWEIAGVPV LFEWGYFSDH ENSFPQELLD KLVERANLPG YLGNCHSSGT 
       160        170        180        190        200
VILDQLGEEH MKTGKPIFYT SADSVFQIAC HEETFGLDKL YELCEIAREE 
       210        220        230        240        250
LTNGGYNIGR VIARPFIGDK AGNFQRTGNR HDLAVEPPAP TVLQKLVDEK 
       260        270        280        290        300
HGQVVSVGKI ADIYANCGIT KKVKATGLDA LFDATIKEMK EAGDNTIVFT 
       310        320        330        340        350
NFVDFDSSWG HRRDVAGYAA GLELFDRRLP ELMSLLRDDD ILILTADHGC 
       360        370        380        390        400
DPTWTGTDHT REHIPVLVYG PKVKPGSLGH RETFADIGQT LAKYFGTSDM 

EYGKAMF
Length:407
Mass (Da):44,370
Last modified:March 29, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i516F3018DC77A077
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97279.1
U00096 Genomic DNA Translation: AAC77336.1
AP009048 Genomic DNA Translation: BAE78372.1
X00742 Genomic DNA Translation: CAA25325.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56607

NCBI Reference Sequences

More...RefSeqi		NP_418800.1, NC_000913.3
WP_000816471.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77336; AAC77336; b4383
BAE78372; BAE78372; BAE78372

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4346
eco:b4383

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2302

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97279.1
U00096 Genomic DNA Translation: AAC77336.1
AP009048 Genomic DNA Translation: BAE78372.1
X00742 Genomic DNA Translation: CAA25325.1
PIRiS56607
RefSeqiNP_418800.1, NC_000913.3
WP_000816471.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0A6K6
SMRiP0A6K6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263160, 14 interactors
DIPiDIP-48057N
IntActiP0A6K6, 6 interactors
STRINGi316385.ECDH10B_4541

PTM databases

iPTMnetiP0A6K6

Proteomic databases

EPDiP0A6K6
PaxDbiP0A6K6
PRIDEiP0A6K6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77336; AAC77336; b4383
BAE78372; BAE78372; BAE78372
GeneIDi948910
KEGGiecj:JW4346
eco:b4383
PATRICifig|1411691.4.peg.2302

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0216
EcoGeneiEG10220 deoB

Phylogenomic databases

eggNOGiENOG4105CZG Bacteria
COG1015 LUCA
HOGENOMiHOG000008159
InParanoidiP0A6K6
KOiK01839
PhylomeDBiP0A6K6

Enzyme and pathway databases

UniPathwayi
UPA00087;UER00173

BioCyciEcoCyc:PPENTOMUT-MONOMER
MetaCyc:PPENTOMUT-MONOMER
BRENDAi5.4.2.7 2026

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0A6K6

Family and domain databases

CDDicd16009 PPM, 1 hit
Gene3Di3.30.70.1250, 1 hit
3.40.720.10, 1 hit
HAMAPiMF_00740 Phosphopentomut, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR010045 DeoB
IPR006124 Metalloenzyme
IPR024052 Phosphopentomutase_DeoB_cap_sf
PANTHERiPTHR21110 PTHR21110, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001491 Ppentomutase, 1 hit
SUPFAMiSSF143856 SSF143856, 1 hit
SSF53649 SSF53649, 1 hit
TIGRFAMsiTIGR01696 deoB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEOB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A6K6
Secondary accession number(s): P07651, Q2M5T4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: March 29, 2005
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again