UniProtKB - P0A6K6 (DEOB_ECOLI)
Protein
Phosphopentomutase
Gene
deoB
Organism
Escherichia coli (strain K12)
Status
Functioni
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
Catalytic activityi
Cofactori
Mn2+CuratedNote: Binds 1 or 2 manganese ions.Curated
: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Phosphopentomutase (deoB), Phosphopentomutase (deoB)
- no protein annotated in this organism
- Ribose 1,5-bisphosphate phosphokinase PhnN (phnN), Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 10 | ManganeseBy similarity | 1 | |
Metal bindingi | 311 | ManganeseBy similarity | 1 | |
Metal bindingi | 347 | ManganeseBy similarity | 1 | |
Metal bindingi | 348 | ManganeseBy similarity | 1 | |
Metal bindingi | 359 | ManganeseBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- manganese ion binding Source: UniProtKB-UniRule
- phosphopentomutase activity Source: EcoCyc
GO - Biological processi
- 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
- cellular metabolic compound salvage Source: InterPro
- cellular response to DNA damage stimulus Source: EcoliWiki
- deoxyribonucleotide catabolic process Source: EcoCyc
Keywordsi
Molecular function | Isomerase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:PPENTOMUT-MONOMER MetaCyc:PPENTOMUT-MONOMER |
BRENDAi | 5.4.2.7, 2026 |
UniPathwayi | UPA00087;UER00173 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:deoB Synonyms:drm, thyR Ordered Locus Names:b4383, JW4346 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytosol Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199819 | 1 – 407 | PhosphopentomutaseAdd BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 287 | N6-acetyllysine1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P0A6K6 |
PaxDbi | P0A6K6 |
PRIDEi | P0A6K6 |
PTM databases
iPTMneti | P0A6K6 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263160, 14 interactors 853187, 1 interactor |
DIPi | DIP-48057N |
IntActi | P0A6K6, 6 interactors |
STRINGi | 511145.b4383 |
Family & Domainsi
Sequence similaritiesi
Belongs to the phosphopentomutase family.Curated
Phylogenomic databases
eggNOGi | COG1015, Bacteria |
HOGENOMi | CLU_053861_0_0_6 |
InParanoidi | P0A6K6 |
PhylomeDBi | P0A6K6 |
Family and domain databases
CDDi | cd16009, PPM, 1 hit |
Gene3Di | 3.30.70.1250, 1 hit 3.40.720.10, 1 hit |
HAMAPi | MF_00740, Phosphopentomut, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR010045, DeoB IPR006124, Metalloenzyme IPR024052, Phosphopentomutase_DeoB_cap_sf |
PANTHERi | PTHR21110, PTHR21110, 1 hit |
Pfami | View protein in Pfam PF01676, Metalloenzyme, 1 hit |
PIRSFi | PIRSF001491, Ppentomutase, 1 hit |
SUPFAMi | SSF143856, SSF143856, 1 hit SSF53649, SSF53649, 1 hit |
TIGRFAMsi | TIGR01696, deoB, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6K6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRAFIMVLD SFGIGATEDA ERFGDVGADT LGHIAEACAK GEADNGRKGP
60 70 80 90 100
LNLPNLTRLG LAKAHEGSTG FIPAGMDGNA EVIGAYAWAH EMSSGKDTPS
110 120 130 140 150
GHWEIAGVPV LFEWGYFSDH ENSFPQELLD KLVERANLPG YLGNCHSSGT
160 170 180 190 200
VILDQLGEEH MKTGKPIFYT SADSVFQIAC HEETFGLDKL YELCEIAREE
210 220 230 240 250
LTNGGYNIGR VIARPFIGDK AGNFQRTGNR HDLAVEPPAP TVLQKLVDEK
260 270 280 290 300
HGQVVSVGKI ADIYANCGIT KKVKATGLDA LFDATIKEMK EAGDNTIVFT
310 320 330 340 350
NFVDFDSSWG HRRDVAGYAA GLELFDRRLP ELMSLLRDDD ILILTADHGC
360 370 380 390 400
DPTWTGTDHT REHIPVLVYG PKVKPGSLGH RETFADIGQT LAKYFGTSDM
EYGKAMF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97279.1 U00096 Genomic DNA Translation: AAC77336.1 AP009048 Genomic DNA Translation: BAE78372.1 X00742 Genomic DNA Translation: CAA25325.1 |
PIRi | S56607 |
RefSeqi | NP_418800.1, NC_000913.3 WP_000816471.1, NZ_STEB01000033.1 |
Genome annotation databases
EnsemblBacteriai | AAC77336; AAC77336; b4383 BAE78372; BAE78372; BAE78372 |
GeneIDi | 52075306 948910 |
KEGGi | ecj:JW4346 eco:b4383 |
PATRICi | fig|1411691.4.peg.2302 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97279.1 U00096 Genomic DNA Translation: AAC77336.1 AP009048 Genomic DNA Translation: BAE78372.1 X00742 Genomic DNA Translation: CAA25325.1 |
PIRi | S56607 |
RefSeqi | NP_418800.1, NC_000913.3 WP_000816471.1, NZ_STEB01000033.1 |
3D structure databases
SMRi | P0A6K6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263160, 14 interactors 853187, 1 interactor |
DIPi | DIP-48057N |
IntActi | P0A6K6, 6 interactors |
STRINGi | 511145.b4383 |
PTM databases
iPTMneti | P0A6K6 |
Proteomic databases
jPOSTi | P0A6K6 |
PaxDbi | P0A6K6 |
PRIDEi | P0A6K6 |
Genome annotation databases
EnsemblBacteriai | AAC77336; AAC77336; b4383 BAE78372; BAE78372; BAE78372 |
GeneIDi | 52075306 948910 |
KEGGi | ecj:JW4346 eco:b4383 |
PATRICi | fig|1411691.4.peg.2302 |
Organism-specific databases
EchoBASEi | EB0216 |
Phylogenomic databases
eggNOGi | COG1015, Bacteria |
HOGENOMi | CLU_053861_0_0_6 |
InParanoidi | P0A6K6 |
PhylomeDBi | P0A6K6 |
Enzyme and pathway databases
UniPathwayi | UPA00087;UER00173 |
BioCyci | EcoCyc:PPENTOMUT-MONOMER MetaCyc:PPENTOMUT-MONOMER |
BRENDAi | 5.4.2.7, 2026 |
Miscellaneous databases
PROi | PR:P0A6K6 |
Family and domain databases
CDDi | cd16009, PPM, 1 hit |
Gene3Di | 3.30.70.1250, 1 hit 3.40.720.10, 1 hit |
HAMAPi | MF_00740, Phosphopentomut, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR010045, DeoB IPR006124, Metalloenzyme IPR024052, Phosphopentomutase_DeoB_cap_sf |
PANTHERi | PTHR21110, PTHR21110, 1 hit |
Pfami | View protein in Pfam PF01676, Metalloenzyme, 1 hit |
PIRSFi | PIRSF001491, Ppentomutase, 1 hit |
SUPFAMi | SSF143856, SSF143856, 1 hit SSF53649, SSF53649, 1 hit |
TIGRFAMsi | TIGR01696, deoB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DEOB_ECOLI | |
Accessioni | P0A6K6Primary (citable) accession number: P0A6K6 Secondary accession number(s): P07651, Q2M5T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | March 29, 2005 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families