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Protein

Phosphopentomutase

Gene

deoB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.

Cofactori

Mn2+CuratedNote: Binds 1 or 2 manganese ions.Curated

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10ManganeseBy similarity1
Metal bindingi311ManganeseBy similarity1
Metal bindingi347ManganeseBy similarity1
Metal bindingi348ManganeseBy similarity1
Metal bindingi359ManganeseBy similarity1

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • phosphopentomutase activity Source: EcoCyc

GO - Biological processi

  • 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  • cellular metabolic compound salvage Source: InterPro
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • deoxyribonucleotide catabolic process Source: EcoCyc

Keywordsi

Molecular functionIsomerase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:PPENTOMUT-MONOMER
MetaCyc:PPENTOMUT-MONOMER
BRENDAi5.4.2.7 2026
UniPathwayiUPA00087; UER00173

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopentomutase (EC:5.4.2.7)
Alternative name(s):
Phosphodeoxyribomutase
Gene namesi
Name:deoB
Synonyms:drm, thyR
Ordered Locus Names:b4383, JW4346
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10220 deoB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998191 – 407PhosphopentomutaseAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0A6K6
PaxDbiP0A6K6
PRIDEiP0A6K6

PTM databases

iPTMnetiP0A6K6

Interactioni

Protein-protein interaction databases

BioGridi4263160, 14 interactors
DIPiDIP-48057N
IntActiP0A6K6, 6 interactors
STRINGi316385.ECDH10B_4541

Structurei

3D structure databases

ProteinModelPortaliP0A6K6
SMRiP0A6K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.Curated

Phylogenomic databases

eggNOGiENOG4105CZG Bacteria
COG1015 LUCA
HOGENOMiHOG000008159
InParanoidiP0A6K6
KOiK01839
OMAiCHASGTE
PhylomeDBiP0A6K6

Family and domain databases

CDDicd16009 PPM, 1 hit
Gene3Di3.30.70.1250, 1 hit
3.40.720.10, 2 hits
HAMAPiMF_00740 Phosphopentomut, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR010045 DeoB
IPR006124 Metalloenzyme
IPR024052 Phosphopentomutase_DeoB_cap_sf
PANTHERiPTHR21110 PTHR21110, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001491 Ppentomutase, 1 hit
SUPFAMiSSF143856 SSF143856, 1 hit
SSF53649 SSF53649, 2 hits
TIGRFAMsiTIGR01696 deoB, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAFIMVLD SFGIGATEDA ERFGDVGADT LGHIAEACAK GEADNGRKGP
60 70 80 90 100
LNLPNLTRLG LAKAHEGSTG FIPAGMDGNA EVIGAYAWAH EMSSGKDTPS
110 120 130 140 150
GHWEIAGVPV LFEWGYFSDH ENSFPQELLD KLVERANLPG YLGNCHSSGT
160 170 180 190 200
VILDQLGEEH MKTGKPIFYT SADSVFQIAC HEETFGLDKL YELCEIAREE
210 220 230 240 250
LTNGGYNIGR VIARPFIGDK AGNFQRTGNR HDLAVEPPAP TVLQKLVDEK
260 270 280 290 300
HGQVVSVGKI ADIYANCGIT KKVKATGLDA LFDATIKEMK EAGDNTIVFT
310 320 330 340 350
NFVDFDSSWG HRRDVAGYAA GLELFDRRLP ELMSLLRDDD ILILTADHGC
360 370 380 390 400
DPTWTGTDHT REHIPVLVYG PKVKPGSLGH RETFADIGQT LAKYFGTSDM

EYGKAMF
Length:407
Mass (Da):44,370
Last modified:March 29, 2005 - v1
Checksum:i516F3018DC77A077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97279.1
U00096 Genomic DNA Translation: AAC77336.1
AP009048 Genomic DNA Translation: BAE78372.1
X00742 Genomic DNA Translation: CAA25325.1
PIRiS56607
RefSeqiNP_418800.1, NC_000913.3
WP_000816471.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77336; AAC77336; b4383
BAE78372; BAE78372; BAE78372
GeneIDi948910
KEGGiecj:JW4346
eco:b4383
PATRICifig|1411691.4.peg.2302

Similar proteinsi

Entry informationi

Entry nameiDEOB_ECOLI
AccessioniPrimary (citable) accession number: P0A6K6
Secondary accession number(s): P07651, Q2M5T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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