We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P0A6I3 (COAA_ECOLI)
Protein
Pantothenate kinase
Gene
coaA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:2.7.1.33
Activity regulationi
Regulated by feedback inhibition by CoA and its thioesters.
: coenzyme A biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate. This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 95 – 102 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- pantetheine kinase activity Source: EcoCyc
- pantothenate kinase activity Source: EcoCyc
GO - Biological processi
- coenzyme A biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Coenzyme A biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:PANTOTHENATE-KIN-MONOMER |
BRENDAi | 2.7.1.33, 2026 |
SABIO-RKi | P0A6I3 |
UniPathwayi | UPA00241;UER00352 |
Names & Taxonomyi
Protein namesi | Recommended name: Pantothenate kinase (EC:2.7.1.33)Alternative name(s): Pantothenic acid kinase Rts protein |
Gene namesi | Name:coaA Synonyms:panK, rts Ordered Locus Names:b3974, JW3942 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL5092 |
DrugBanki | DB01992, Coenzyme A DB01783, Pantothenic acid DB04395, Phosphoaminophosphonic Acid-Adenylate Ester |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194426 | 1 – 316 | Pantothenate kinaseAdd BLAST | 316 |
Proteomic databases
jPOSTi | P0A6I3 |
PaxDbi | P0A6I3 |
PRIDEi | P0A6I3 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6I3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A6I3 |
Family & Domainsi
Sequence similaritiesi
Belongs to the prokaryotic pantothenate kinase family.Curated
Phylogenomic databases
eggNOGi | COG1072, Bacteria |
HOGENOMi | CLU_053818_1_1_6 |
InParanoidi | P0A6I3 |
PhylomeDBi | P0A6I3 |
Family and domain databases
CDDi | cd02025, PanK, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00215, Pantothen_kinase_1, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR004566, PanK IPR006083, PRK/URK |
PANTHERi | PTHR10285:SF139, PTHR10285:SF139, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
PIRSFi | PIRSF000545, Pantothenate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00554, panK_bact, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6I3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIKEQTLMT PYLQFDRNQW AALRDSVPMT LSEDEIARLK GINEDLSLEE
60 70 80 90 100
VAEIYLPLSR LLNFYISSNL RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG
110 120 130 140 150
KSTTARVLQA LLSRWPEHRR VELITTDGFL HPNQVLKERG LMKKKGFPES
160 170 180 190 200
YDMHRLVKFV SDLKSGVPNV TAPVYSHLIY DVIPDGDKTV VQPDILILEG
210 220 230 240 250
LNVLQSGMDY PHDPHHVFVS DFVDFSIYVD APEDLLQTWY INRFLKFREG
260 270 280 290 300
AFTDPDSYFH NYAKLTKEEA IKTAMTLWKE INWLNLKQNI LPTRERASLI
310
LTKSANHAVE EVRLRK
Sequence cautioni
The sequence AAA23591 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA76838 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36321 Genomic DNA Translation: AAA76838.1 Different initiation. M90071 Genomic DNA Translation: AAA23590.1 M90071 Genomic DNA Translation: AAA23591.1 Different initiation. U00006 Genomic DNA Translation: AAC43076.1 U00096 Genomic DNA Translation: AAC76952.1 AP009048 Genomic DNA Translation: BAE77341.1 |
PIRi | A45727, BVECRS |
RefSeqi | NP_418405.1, NC_000913.3 WP_000023081.1, NZ_STEB01000072.1 |
Genome annotation databases
EnsemblBacteriai | AAC76952; AAC76952; b3974 BAE77341; BAE77341; BAE77341 |
GeneIDi | 66672114 948479 |
KEGGi | ecj:JW3942 eco:b3974 |
PATRICi | fig|511145.12.peg.4091 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36321 Genomic DNA Translation: AAA76838.1 Different initiation. M90071 Genomic DNA Translation: AAA23590.1 M90071 Genomic DNA Translation: AAA23591.1 Different initiation. U00006 Genomic DNA Translation: AAC43076.1 U00096 Genomic DNA Translation: AAC76952.1 AP009048 Genomic DNA Translation: BAE77341.1 |
PIRi | A45727, BVECRS |
RefSeqi | NP_418405.1, NC_000913.3 WP_000023081.1, NZ_STEB01000072.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ESM | X-ray | 2.50 | A/B/C/D | 1-316 | [»] | |
1ESN | X-ray | 2.60 | A/B/C/D | 1-316 | [»] | |
1SQ5 | X-ray | 2.20 | A/B/C/D | 9-316 | [»] | |
SMRi | P0A6I3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P0A6I3, 2 interactors |
STRINGi | 511145.b3974 |
Chemistry databases
ChEMBLi | CHEMBL5092 |
DrugBanki | DB01992, Coenzyme A DB01783, Pantothenic acid DB04395, Phosphoaminophosphonic Acid-Adenylate Ester |
Proteomic databases
jPOSTi | P0A6I3 |
PaxDbi | P0A6I3 |
PRIDEi | P0A6I3 |
Genome annotation databases
EnsemblBacteriai | AAC76952; AAC76952; b3974 BAE77341; BAE77341; BAE77341 |
GeneIDi | 66672114 948479 |
KEGGi | ecj:JW3942 eco:b3974 |
PATRICi | fig|511145.12.peg.4091 |
Organism-specific databases
EchoBASEi | EB0915 |
Phylogenomic databases
eggNOGi | COG1072, Bacteria |
HOGENOMi | CLU_053818_1_1_6 |
InParanoidi | P0A6I3 |
PhylomeDBi | P0A6I3 |
Enzyme and pathway databases
UniPathwayi | UPA00241;UER00352 |
BioCyci | EcoCyc:PANTOTHENATE-KIN-MONOMER |
BRENDAi | 2.7.1.33, 2026 |
SABIO-RKi | P0A6I3 |
Miscellaneous databases
EvolutionaryTracei | P0A6I3 |
PROi | PR:P0A6I3 |
Family and domain databases
CDDi | cd02025, PanK, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00215, Pantothen_kinase_1, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR004566, PanK IPR006083, PRK/URK |
PANTHERi | PTHR10285:SF139, PTHR10285:SF139, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
PIRSFi | PIRSF000545, Pantothenate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00554, panK_bact, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COAA_ECOLI | |
Accessioni | P0A6I3Primary (citable) accession number: P0A6I3 Secondary accession number(s): P15044, Q2M8R5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families