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UniProtKB - P0A6I3 (COAA_ECOLI)

Entry version 126 (29 Sep 2021)
Sequence version 1 (29 Mar 2005)
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Protein

Pantothenate kinase

Gene

coaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Regulated by feedback inhibition by CoA and its thioesters.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate. This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi95 – 102ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • coenzyme A biosynthetic process Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PANTOTHENATE-KIN-MONOMER
MetaCyc:PANTOTHENATE-KIN-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.33, 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P0A6I3

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00241;UER00352

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pantothenate kinase (EC:2.7.1.33)
Alternative name(s):
Pantothenic acid kinase
Rts protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:coaA
Synonyms:panK, rts
Ordered Locus Names:b3974, JW3942
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5092

Drug and drug target database

More...DrugBanki		DB01992, Coenzyme A
DB01783, Pantothenic acid
DB04395, Phosphoaminophosphonic Acid-Adenylate Ester

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001944261 – 316Pantothenate kinaseAdd BLAST316

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0A6I3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0A6I3

PRoteomics IDEntifications database

More...PRIDEi		P0A6I3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P0A6I3, 2 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3974

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0A6I3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P0A6I3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1072, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053818_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0A6I3

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0A6I3

Family and domain databases

Conserved Domains Database

More...CDDi		cd02025, PanK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00215, Pantothen_kinase_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR004566, PanK
IPR006083, PRK/URK

The PANTHER Classification System

More...PANTHERi		PTHR10285:SF139, PTHR10285:SF139, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00485, PRK, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000545, Pantothenate_kin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00554, panK_bact, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A6I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIKEQTLMT PYLQFDRNQW AALRDSVPMT LSEDEIARLK GINEDLSLEE 
        60         70         80         90        100
VAEIYLPLSR LLNFYISSNL RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG 
       110        120        130        140        150
KSTTARVLQA LLSRWPEHRR VELITTDGFL HPNQVLKERG LMKKKGFPES 
       160        170        180        190        200
YDMHRLVKFV SDLKSGVPNV TAPVYSHLIY DVIPDGDKTV VQPDILILEG 
       210        220        230        240        250
LNVLQSGMDY PHDPHHVFVS DFVDFSIYVD APEDLLQTWY INRFLKFREG 
       260        270        280        290        300
AFTDPDSYFH NYAKLTKEEA IKTAMTLWKE INWLNLKQNI LPTRERASLI 
       310 
LTKSANHAVE EVRLRK
Length:316
Mass (Da):36,360
Last modified:March 29, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDDC1922C5C52A70
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA23591 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA76838 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M36321 Genomic DNA Translation: AAA76838.1 Different initiation.
M90071 Genomic DNA Translation: AAA23590.1
M90071 Genomic DNA Translation: AAA23591.1 Different initiation.
U00006 Genomic DNA Translation: AAC43076.1
U00096 Genomic DNA Translation: AAC76952.1
AP009048 Genomic DNA Translation: BAE77341.1

Protein sequence database of the Protein Information Resource

More...PIRi		A45727, BVECRS

NCBI Reference Sequences

More...RefSeqi		NP_418405.1, NC_000913.3
WP_000023081.1, NZ_STEB01000072.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76952; AAC76952; b3974
BAE77341; BAE77341; BAE77341

Database of genes from NCBI RefSeq genomes

More...GeneIDi		61755108
948479

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3942
eco:b3974

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.4091

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36321 Genomic DNA Translation: AAA76838.1 Different initiation.
M90071 Genomic DNA Translation: AAA23590.1
M90071 Genomic DNA Translation: AAA23591.1 Different initiation.
U00006 Genomic DNA Translation: AAC43076.1
U00096 Genomic DNA Translation: AAC76952.1
AP009048 Genomic DNA Translation: BAE77341.1
PIRiA45727, BVECRS
RefSeqiNP_418405.1, NC_000913.3
WP_000023081.1, NZ_STEB01000072.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ESMX-ray2.50A/B/C/D1-316[»]
1ESNX-ray2.60A/B/C/D1-316[»]
1SQ5X-ray2.20A/B/C/D9-316[»]
SMRiP0A6I3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP0A6I3, 2 interactors
STRINGi511145.b3974

Chemistry databases

ChEMBLiCHEMBL5092
DrugBankiDB01992, Coenzyme A
DB01783, Pantothenic acid
DB04395, Phosphoaminophosphonic Acid-Adenylate Ester

Proteomic databases

jPOSTiP0A6I3
PaxDbiP0A6I3
PRIDEiP0A6I3

Genome annotation databases

EnsemblBacteriaiAAC76952; AAC76952; b3974
BAE77341; BAE77341; BAE77341
GeneIDi61755108
948479
KEGGiecj:JW3942
eco:b3974
PATRICifig|511145.12.peg.4091

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0915

Phylogenomic databases

eggNOGiCOG1072, Bacteria
HOGENOMiCLU_053818_1_1_6
InParanoidiP0A6I3
PhylomeDBiP0A6I3

Enzyme and pathway databases

UniPathwayiUPA00241;UER00352
BioCyciEcoCyc:PANTOTHENATE-KIN-MONOMER
MetaCyc:PANTOTHENATE-KIN-MONOMER
BRENDAi2.7.1.33, 2026
SABIO-RKiP0A6I3

Miscellaneous databases

EvolutionaryTraceiP0A6I3

Protein Ontology

More...PROi		PR:P0A6I3

Family and domain databases

CDDicd02025, PanK, 1 hit
Gene3Di3.40.50.300, 1 hit
HAMAPiMF_00215, Pantothen_kinase_1, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR004566, PanK
IPR006083, PRK/URK
PANTHERiPTHR10285:SF139, PTHR10285:SF139, 1 hit
PfamiView protein in Pfam
PF00485, PRK, 1 hit
PIRSFiPIRSF000545, Pantothenate_kin, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00554, panK_bact, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOAA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A6I3
Secondary accession number(s): P15044, Q2M8R5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 29, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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