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UniProtKB - P0A6E6 (ATPE_ECOLI)

Entry version 130 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

ATP synthase epsilon chain

Gene

atpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:ATPC-MONOMER
ECOL316407:JW3709-MONOMER
MetaCyc:ATPC-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.2.1.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase epsilon chain
Alternative name(s):
ATP synthase F1 sector epsilon subunit
F-ATPase epsilon subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atpC
Synonyms:papG, uncC
Ordered Locus Names:b3731, JW3709
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...EcoGenei		EG10100 atpC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001881322 – 139ATP synthase epsilon chainAdd BLAST138

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P0A6E6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0A6E6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0A6E6

PRoteomics IDEntifications database

More...PRIDEi		P0A6E6

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P0A6E6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4261177, 67 interactors
852547, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4022 ATP synthase complex

Database of interacting proteins

More...DIPi		DIP-47828N

Protein interaction database and analysis system

More...IntActi		P0A6E6, 7 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3731

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0A6E6

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P0A6E6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105KNM Bacteria
COG0355 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000216025

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0A6E6

KEGG Orthology (KO)

More...KOi		K02114

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0A6E6

Family and domain databases

Conserved Domains Database

More...CDDi		cd12152 F1-ATPase_delta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.15.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00530 ATP_synth_epsil_bac, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036794 ATP_F1_dsu/esu_C_sf
IPR001469 ATP_synth_F1_dsu/esu
IPR020547 ATP_synth_F1_dsu/esu_C
IPR020546 ATP_synth_F1_dsu/esu_N
IPR036771 ATPsynth_dsu/esu_N

The PANTHER Classification System

More...PANTHERi		PTHR13822 PTHR13822, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00401 ATP-synt_DE, 1 hit
PF02823 ATP-synt_DE_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46604 SSF46604, 1 hit
SSF51344 SSF51344, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01216 ATP_synt_epsi, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0A6E6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMTYHLDVV SAEQQMFSGL VEKIQVTGSE GELGIYPGHA PLLTAIKPGM 
        60         70         80         90        100
IRIVKQHGHE EFIYLSGGIL EVQPGNVTVL ADTAIRGQDL DEARAMEAKR 
       110        120        130 
KAEEHISSSH GDVDYAQASA ELAKAIAQLR VIELTKKAM
Length:139
Mass (Da):15,068
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EFF7DE911745A62
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA23528 differs from that shown. Reason: Frameshift at position 132.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13E → K AA sequence (PubMed:9868784).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J01594 Genomic DNA Translation: AAA24738.1
X01631 Genomic DNA Translation: CAA25783.1
V00311 Genomic DNA Translation: CAA23595.1
M25464 Genomic DNA Translation: AAA83876.1
V00267 Genomic DNA Translation: CAA23528.1 Frameshift.
L10328 Genomic DNA Translation: AAA62083.1
U00096 Genomic DNA Translation: AAC76754.1
AP009048 Genomic DNA Translation: BAE77557.1

Protein sequence database of the Protein Information Resource

More...PIRi		B90106 PWECE

NCBI Reference Sequences

More...RefSeqi		NP_418187.1, NC_000913.3
WP_001251965.1, NZ_STEB01000015.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76754; AAC76754; b3731
BAE77557; BAE77557; BAE77557

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948245

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3709
eco:b3731

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2969

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01594 Genomic DNA Translation: AAA24738.1
X01631 Genomic DNA Translation: CAA25783.1
V00311 Genomic DNA Translation: CAA23595.1
M25464 Genomic DNA Translation: AAA83876.1
V00267 Genomic DNA Translation: CAA23528.1 Frameshift.
L10328 Genomic DNA Translation: AAA62083.1
U00096 Genomic DNA Translation: AAC76754.1
AP009048 Genomic DNA Translation: BAE77557.1
PIRiB90106 PWECE
RefSeqiNP_418187.1, NC_000913.3
WP_001251965.1, NZ_STEB01000015.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQTX-ray2.30A4-139[»]
1BSHNMR-A2-139[»]
1BSNNMR-A2-139[»]
1FS0X-ray2.10E2-139[»]
1QO1X-ray3.90J4-139[»]
3OAAX-ray3.26H/P/X/f2-139[»]
5T4Oelectron microscopy6.90H1-139[»]
5T4Pelectron microscopy7.77H1-139[»]
5T4Qelectron microscopy8.53H1-139[»]
SMRiP0A6E6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4261177, 67 interactors
852547, 4 interactors
ComplexPortaliCPX-4022 ATP synthase complex
DIPiDIP-47828N
IntActiP0A6E6, 7 interactors
STRINGi511145.b3731

Protein family/group databases

TCDBi3.A.2.1.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

2D gel databases

SWISS-2DPAGEiP0A6E6

Proteomic databases

EPDiP0A6E6
jPOSTiP0A6E6
PaxDbiP0A6E6
PRIDEiP0A6E6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76754; AAC76754; b3731
BAE77557; BAE77557; BAE77557
GeneIDi948245
KEGGiecj:JW3709
eco:b3731
PATRICifig|1411691.4.peg.2969

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0098
EcoGeneiEG10100 atpC

Phylogenomic databases

eggNOGiENOG4105KNM Bacteria
COG0355 LUCA
HOGENOMiHOG000216025
InParanoidiP0A6E6
KOiK02114
PhylomeDBiP0A6E6

Enzyme and pathway databases

BioCyciEcoCyc:ATPC-MONOMER
ECOL316407:JW3709-MONOMER
MetaCyc:ATPC-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A6E6

Protein Ontology

More...PROi		PR:P0A6E6

Family and domain databases

CDDicd12152 F1-ATPase_delta, 1 hit
Gene3Di2.60.15.10, 1 hit
HAMAPiMF_00530 ATP_synth_epsil_bac, 1 hit
InterProiView protein in InterPro
IPR036794 ATP_F1_dsu/esu_C_sf
IPR001469 ATP_synth_F1_dsu/esu
IPR020547 ATP_synth_F1_dsu/esu_C
IPR020546 ATP_synth_F1_dsu/esu_N
IPR036771 ATPsynth_dsu/esu_N
PANTHERiPTHR13822 PTHR13822, 1 hit
PfamiView protein in Pfam
PF00401 ATP-synt_DE, 1 hit
PF02823 ATP-synt_DE_N, 1 hit
SUPFAMiSSF46604 SSF46604, 1 hit
SSF51344 SSF51344, 1 hit
TIGRFAMsiTIGR01216 ATP_synt_epsi, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATPE_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A6E6
Secondary accession number(s): P00832, Q2M849
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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