UniProtKB - P0A6E6 (ATPE_ECOLI)
Protein
ATP synthase epsilon chain
Gene
atpC
Organism
Escherichia coli (strain K12)
Status
Functioni
Produces ATP from ADP in the presence of a proton gradient across the membrane.
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- proton-transporting ATP synthase activity, rotational mechanism Source: EcoCyc
GO - Biological processi
- ATP synthesis coupled proton transport Source: GO_Central
Keywordsi
Biological process | ATP synthesis, Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:ATPC-MONOMER MetaCyc:ATPC-MONOMER |
Protein family/group databases
TCDBi | 3.A.2.1.1, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase epsilon chainAlternative name(s): ATP synthase F1 sector epsilon subunit F-ATPase epsilon subunit |
Gene namesi | Name:atpC Synonyms:papG, uncC Ordered Locus Names:b3731, JW3709 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 2 Publications; Peripheral membrane protein 2 Publications
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- proton-transporting ATP synthase complex, catalytic core F(1) Source: EcoliWiki
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, CF(1), MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000188132 | 2 – 139 | ATP synthase epsilon chainAdd BLAST | 138 |
Proteomic databases
jPOSTi | P0A6E6 |
PaxDbi | P0A6E6 |
PRIDEi | P0A6E6 |
2D gel databases
SWISS-2DPAGEi | P0A6E6 |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 4261177, 67 interactors 852547, 4 interactors |
ComplexPortali | CPX-4022, ATP synthase complex |
DIPi | DIP-47828N |
IntActi | P0A6E6, 7 interactors |
STRINGi | 511145.b3731 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A6E6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A6E6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATPase epsilon chain family.Curated
Phylogenomic databases
eggNOGi | COG0355, Bacteria |
HOGENOMi | CLU_084338_2_0_6 |
InParanoidi | P0A6E6 |
PhylomeDBi | P0A6E6 |
Family and domain databases
CDDi | cd12152, F1-ATPase_delta, 1 hit |
Gene3Di | 2.60.15.10, 1 hit |
HAMAPi | MF_00530, ATP_synth_epsil_bac, 1 hit |
InterProi | View protein in InterPro IPR036794, ATP_F1_dsu/esu_C_sf IPR001469, ATP_synth_F1_dsu/esu IPR020547, ATP_synth_F1_dsu/esu_C IPR020546, ATP_synth_F1_dsu/esu_N IPR036771, ATPsynth_dsu/esu_N |
PANTHERi | PTHR13822, PTHR13822, 1 hit |
Pfami | View protein in Pfam PF00401, ATP-synt_DE, 1 hit PF02823, ATP-synt_DE_N, 1 hit |
SUPFAMi | SSF46604, SSF46604, 1 hit SSF51344, SSF51344, 1 hit |
TIGRFAMsi | TIGR01216, ATP_synt_epsi, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A6E6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMTYHLDVV SAEQQMFSGL VEKIQVTGSE GELGIYPGHA PLLTAIKPGM
60 70 80 90 100
IRIVKQHGHE EFIYLSGGIL EVQPGNVTVL ADTAIRGQDL DEARAMEAKR
110 120 130
KAEEHISSSH GDVDYAQASA ELAKAIAQLR VIELTKKAM
Sequence cautioni
The sequence CAA23528 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | E → K AA sequence (PubMed:9868784).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01594 Genomic DNA Translation: AAA24738.1 X01631 Genomic DNA Translation: CAA25783.1 V00311 Genomic DNA Translation: CAA23595.1 M25464 Genomic DNA Translation: AAA83876.1 V00267 Genomic DNA Translation: CAA23528.1 Frameshift. L10328 Genomic DNA Translation: AAA62083.1 U00096 Genomic DNA Translation: AAC76754.1 AP009048 Genomic DNA Translation: BAE77557.1 |
PIRi | B90106, PWECE |
RefSeqi | NP_418187.1, NC_000913.3 WP_001251965.1, NZ_STEB01000015.1 |
Genome annotation databases
EnsemblBacteriai | AAC76754; AAC76754; b3731 BAE77557; BAE77557; BAE77557 |
GeneIDi | 58461064 948245 |
KEGGi | ecj:JW3709 eco:b3731 |
PATRICi | fig|1411691.4.peg.2969 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01594 Genomic DNA Translation: AAA24738.1 X01631 Genomic DNA Translation: CAA25783.1 V00311 Genomic DNA Translation: CAA23595.1 M25464 Genomic DNA Translation: AAA83876.1 V00267 Genomic DNA Translation: CAA23528.1 Frameshift. L10328 Genomic DNA Translation: AAA62083.1 U00096 Genomic DNA Translation: AAC76754.1 AP009048 Genomic DNA Translation: BAE77557.1 |
PIRi | B90106, PWECE |
RefSeqi | NP_418187.1, NC_000913.3 WP_001251965.1, NZ_STEB01000015.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AQT | X-ray | 2.30 | A | 4-139 | [»] | |
1BSH | NMR | - | A | 2-139 | [»] | |
1BSN | NMR | - | A | 2-139 | [»] | |
1FS0 | X-ray | 2.10 | E | 2-139 | [»] | |
1QO1 | X-ray | 3.90 | J | 4-139 | [»] | |
3OAA | X-ray | 3.26 | H/P/X/f | 2-139 | [»] | |
5T4O | electron microscopy | 6.90 | H | 1-139 | [»] | |
5T4P | electron microscopy | 7.77 | H | 1-139 | [»] | |
5T4Q | electron microscopy | 8.53 | H | 1-139 | [»] | |
6OQR | electron microscopy | 3.10 | H | 1-139 | [»] | |
6OQS | electron microscopy | 3.30 | H | 1-139 | [»] | |
6OQT | electron microscopy | 3.10 | H | 1-139 | [»] | |
6OQU | electron microscopy | 3.20 | H | 1-139 | [»] | |
6OQV | electron microscopy | 3.30 | H | 1-139 | [»] | |
6OQW | electron microscopy | 3.10 | H | 1-139 | [»] | |
6PQV | electron microscopy | 3.30 | H | 1-139 | [»] | |
6WNQ | electron microscopy | 3.40 | H | 1-139 | [»] | |
6WNR | electron microscopy | 3.30 | H | 1-139 | [»] | |
SMRi | P0A6E6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261177, 67 interactors 852547, 4 interactors |
ComplexPortali | CPX-4022, ATP synthase complex |
DIPi | DIP-47828N |
IntActi | P0A6E6, 7 interactors |
STRINGi | 511145.b3731 |
Protein family/group databases
TCDBi | 3.A.2.1.1, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
2D gel databases
SWISS-2DPAGEi | P0A6E6 |
Proteomic databases
jPOSTi | P0A6E6 |
PaxDbi | P0A6E6 |
PRIDEi | P0A6E6 |
Genome annotation databases
EnsemblBacteriai | AAC76754; AAC76754; b3731 BAE77557; BAE77557; BAE77557 |
GeneIDi | 58461064 948245 |
KEGGi | ecj:JW3709 eco:b3731 |
PATRICi | fig|1411691.4.peg.2969 |
Organism-specific databases
EchoBASEi | EB0098 |
Phylogenomic databases
eggNOGi | COG0355, Bacteria |
HOGENOMi | CLU_084338_2_0_6 |
InParanoidi | P0A6E6 |
PhylomeDBi | P0A6E6 |
Enzyme and pathway databases
BioCyci | EcoCyc:ATPC-MONOMER MetaCyc:ATPC-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0A6E6 |
PROi | PR:P0A6E6 |
Family and domain databases
CDDi | cd12152, F1-ATPase_delta, 1 hit |
Gene3Di | 2.60.15.10, 1 hit |
HAMAPi | MF_00530, ATP_synth_epsil_bac, 1 hit |
InterProi | View protein in InterPro IPR036794, ATP_F1_dsu/esu_C_sf IPR001469, ATP_synth_F1_dsu/esu IPR020547, ATP_synth_F1_dsu/esu_C IPR020546, ATP_synth_F1_dsu/esu_N IPR036771, ATPsynth_dsu/esu_N |
PANTHERi | PTHR13822, PTHR13822, 1 hit |
Pfami | View protein in Pfam PF00401, ATP-synt_DE, 1 hit PF02823, ATP-synt_DE_N, 1 hit |
SUPFAMi | SSF46604, SSF46604, 1 hit SSF51344, SSF51344, 1 hit |
TIGRFAMsi | TIGR01216, ATP_synt_epsi, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATPE_ECOLI | |
Accessioni | P0A6E6Primary (citable) accession number: P0A6E6 Secondary accession number(s): P00832, Q2M849 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families