Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The mutant strains shown below are all feedback-resistant (fbr) strains exhibiting enhanced arginine biosynthesis.1 Publication

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.1 Publication

Enzyme regulationi

Feedback inhibition by L-arginine.1 Publication

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.1 Publication
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • arginine biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:N-ACETYLTRANSFER-MONOMER
MetaCyc:N-ACETYLTRANSFER-MONOMER
BRENDAi2.3.1.1 2026
UniPathwayiUPA00068; UER00106

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferase (EC:2.3.1.1)
Alternative name(s):
N-acetylglutamate synthase
Short name:
AGS
Short name:
NAGS
Gene namesi
Name:argA
Ordered Locus Names:b2818, JW2786
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10063 argA

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15H → Y in EE17. 1 Publication1
Mutagenesisi19Y → C in EE51. 1 Publication1
Mutagenesisi54S → N in PT2M217. 1 Publication1
Mutagenesisi58R → H in EE11. 1 Publication1
Mutagenesisi287G → S in PT2M216. 1 Publication1
Mutagenesisi432Q → R in PT2M217. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001867901 – 443Amino-acid acetyltransferaseAdd BLAST443

Proteomic databases

PaxDbiP0A6C5
PRIDEiP0A6C5

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

BioGridi4262306, 14 interactors
DIPiDIP-48037N
IntActiP0A6C5, 3 interactors
STRINGi316385.ECDH10B_2988

Structurei

3D structure databases

ProteinModelPortaliP0A6C5
SMRiP0A6C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini296 – 443N-acetyltransferaseAdd BLAST148

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108EKC Bacteria
COG0548 LUCA
COG1246 LUCA
InParanoidiP0A6C5
KOiK14682
OMAiKRKYNWD
PhylomeDBiP0A6C5

Family and domain databases

CDDicd04237 AAK_NAGS-ABP, 1 hit
Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01105 N_acetyl_glu_synth, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR016181 Acyl_CoA_acyltransferase
IPR001048 Asp/Glu/Uridylate_kinase
IPR000182 GNAT_dom
IPR033719 NAGS_kin
IPR010167 NH2A_AcTrfase
PANTHERiPTHR30602 PTHR30602, 1 hit
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF00583 Acetyltransf_1, 1 hit
PIRSFiPIRSF000423 ArgA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01890 N-Ac-Glu-synth, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHE NFSSIVNDIG
60 70 80 90 100
LLHSLGIRLV VVYGARPQID ANLAAHHHEP LYHKNIRVTD AKTLELVKQA
110 120 130 140 150
AGTLQLDITA RLSMSLNNTP LQGAHINVVS GNFIIAQPLG VDDGVDYCHS
160 170 180 190 200
GRIRRIDEDA IHRQLDSGAI VLMGPVAVSV TGESFNLTSE EIATQLAIKL
210 220 230 240 250
KAEKMIGFCS SQGVTNDDGD IVSELFPNEA QARVEAQEEK GDYNSGTVRF
260 270 280 290 300
LRGAVKACRS GVRRCHLISY QEDGALLQEL FSRDGIGTQI VMESAEQIRR
310 320 330 340 350
ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNTTIACA
360 370 380 390 400
ALYPFPEEKI GEMACVAVHP DYRSSSRGEV LLERIAAQAK QSGLSKLFVL
410 420 430 440
TTRSIHWFQE RGFTPVDIDL LPESKKQLYN YQRKSKVLMA DLG
Length:443
Mass (Da):49,195
Last modified:August 1, 1988 - v1
Checksum:iAE0D84902456797A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00492 Genomic DNA Translation: CAA68547.1
AF008115 Genomic DNA Translation: AAC23443.1
AF008116 Genomic DNA Translation: AAC23444.1
AF008117 Genomic DNA Translation: AAC23445.1
AF008118 Genomic DNA Translation: AAC23446.1
AF008119 Genomic DNA Translation: AAC23447.1
U29581 Genomic DNA Translation: AAB40465.1
U00096 Genomic DNA Translation: AAC75857.1
AP009048 Genomic DNA Translation: BAE76887.1
PIRiA30372 XYECAA
RefSeqiNP_417295.1, NC_000913.3
WP_000237947.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75857; AAC75857; b2818
BAE76887; BAE76887; BAE76887
GeneIDi947289
KEGGiecj:JW2786
eco:b2818
PATRICifig|1411691.4.peg.3918

Similar proteinsi

Entry informationi

Entry nameiARGA_ECOLI
AccessioniPrimary (citable) accession number: P0A6C5
Secondary accession number(s): O68009
, O68010, O68011, O68012, O68013, P08205, Q2MA19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health