argA

Functionⁱ

Miscellaneous

The mutant strains shown below are all feedback-resistant (fbr) strains exhibiting enhanced arginine biosynthesis.1 Publication

Catalytic activityⁱ

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.1 Publication

Enzyme regulationⁱ

Feedback inhibition by L-arginine.1 Publication

Pathwayⁱ: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.1 Publication
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

Amino-acid acetyltransferase (argA)
Acetylglutamate kinase (argB)
N-acetyl-gamma-glutamyl-phosphate reductase (argC)
Acetylornithine/succinyldiaminopimelate aminotransferase (argD)

This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functionⁱ

acetyl-CoA:L-glutamate N-acetyltransferase activity Source: UniProtKB-EC
glutamate N-acetyltransferase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 16890
- 17651682
methione N-acyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arginine biosynthetic process
Source: EcoCyc
Inferred from direct assayⁱ
- 17651682

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCycⁱ	EcoCyc:N-ACETYLTRANSFER-MONOMER MetaCyc:N-ACETYLTRANSFER-MONOMER
BRENDAⁱ	2.3.1.1 2026
UniPathwayⁱ	UPA00068; UER00106

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amino-acid acetyltransferase (EC:2.3.1.1) Alternative name(s): N-acetylglutamate synthase Short name: AGS Short name: NAGS
Gene namesⁱ	Name:argA Ordered Locus Names:b2818, JW2786
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10063 argA

EcoGeneⁱ

EG10063 argA

Subcellular locationⁱ

Cytoplasm
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.5
  "N-acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties."
  Marvil D.K., Leisinger T.
  J. Biol. Chem. 252:3295-3303(1977) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION, PATHWAY, SUBUNIT, SUBCELLULAR LOCATION.

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	15	H → Y in EE17. 1 Publication	1
Mutagenesisⁱ	19	Y → C in EE51. 1 Publication	1
Mutagenesisⁱ	54	S → N in PT2M217. 1 Publication	1
Mutagenesisⁱ	58	R → H in EE11. 1 Publication	1
Mutagenesisⁱ	287	G → S in PT2M216. 1 Publication	1
Mutagenesisⁱ	432	Q → R in PT2M217. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186790	1 – 443	Amino-acid acetyltransferaseAdd BLAST		443

Proteomic databases

PaxDbⁱ	P0A6C5
PRIDEⁱ	P0A6C5

Interactionⁱ

Subunit structureⁱ

Homohexamer.1 Publication

Protein-protein interaction databases

BioGridⁱ	4262306, 14 interactors
Database of interacting proteins More...DIPⁱ	DIP-48037N
IntActⁱ	P0A6C5, 3 interactors
STRINGⁱ	316385.ECDH10B_2988

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0A6C5
SMRⁱ	P0A6C5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	296 – 443	N-acetyltransferaseAdd BLAST		148

Sequence similaritiesⁱ

Belongs to the acetyltransferase family. ArgA subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4108EKC Bacteria COG0548 LUCA COG1246 LUCA
InParanoidⁱ	P0A6C5
KEGG Orthology (KO) More...KOⁱ	K14682
OMAⁱ	KRKYNWD
PhylomeDBⁱ	P0A6C5

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04237 AAK_NAGS-ABP, 1 hit
Gene3Dⁱ	3.40.1160.10, 1 hit
HAMAPⁱ	MF_01105 N_acetyl_glu_synth, 1 hit
InterProⁱ	View protein in InterPro IPR036393 AceGlu_kinase-like_sf IPR016181 Acyl_CoA_acyltransferase IPR001048 Asp/Glu/Uridylate_kinase IPR000182 GNAT_dom IPR033719 NAGS_kin IPR010167 NH2A_AcTrfase
PANTHERⁱ	PTHR30602 PTHR30602, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00696 AA_kinase, 1 hit PF00583 Acetyltransf_1, 1 hit
PIRSFⁱ	PIRSF000423 ArgA, 1 hit
SUPFAMⁱ	SSF53633 SSF53633, 1 hit SSF55729 SSF55729, 1 hit
TIGRFAMsⁱ	TIGR01890 N-Ac-Glu-synth, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0A6C5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHE NFSSIVNDIG 
        60         70         80         90        100
LLHSLGIRLV VVYGARPQID ANLAAHHHEP LYHKNIRVTD AKTLELVKQA 
       110        120        130        140        150
AGTLQLDITA RLSMSLNNTP LQGAHINVVS GNFIIAQPLG VDDGVDYCHS 
       160        170        180        190        200
GRIRRIDEDA IHRQLDSGAI VLMGPVAVSV TGESFNLTSE EIATQLAIKL 
       210        220        230        240        250
KAEKMIGFCS SQGVTNDDGD IVSELFPNEA QARVEAQEEK GDYNSGTVRF 
       260        270        280        290        300
LRGAVKACRS GVRRCHLISY QEDGALLQEL FSRDGIGTQI VMESAEQIRR 
       310        320        330        340        350
ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNTTIACA 
       360        370        380        390        400
ALYPFPEEKI GEMACVAVHP DYRSSSRGEV LLERIAAQAK QSGLSKLFVL 
       410        420        430        440 
TTRSIHWFQE RGFTPVDIDL LPESKKQLYN YQRKSKVLMA DLG

Length:443

Mass (Da):49,195

Last modified:August 1, 1988 - v1

Checksum:ⁱAE0D84902456797A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00492 Genomic DNA Translation: CAA68547.1 AF008115 Genomic DNA Translation: AAC23443.1 AF008116 Genomic DNA Translation: AAC23444.1 AF008117 Genomic DNA Translation: AAC23445.1 AF008118 Genomic DNA Translation: AAC23446.1 AF008119 Genomic DNA Translation: AAC23447.1 U29581 Genomic DNA Translation: AAB40465.1 U00096 Genomic DNA Translation: AAC75857.1 AP009048 Genomic DNA Translation: BAE76887.1
PIRⁱ	A30372 XYECAA
NCBI Reference Sequences More...RefSeqⁱ	NP_417295.1, NC_000913.3 WP_000237947.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75857; AAC75857; b2818 BAE76887; BAE76887; BAE76887
GeneIDⁱ	947289
KEGGⁱ	ecj:JW2786 eco:b2818
PATRICⁱ	fig\|1411691.4.peg.3918

Protein	Similar proteins		Species	Score	Length
P0A6C5	Amino-acid acetyltransferase		ECO57		443
Amino-acid acetyltransferase		ECOL6		443
Amino-acid acetyltransferase		Escherichia coli NCCP15648		443
Amino-acid acetyltransferase		Klebsiella pneumoniae IS22		443
Amino-acid acetyltransferase		Escherichia coli D6-113.11		443
+116

Protein	Similar proteins		Species	Score	Length
P0A6C5	Amino-acid acetyltransferase		SHIFL		443
Amino-acid acetyltransferase		Shigella flexneri 1235-66		443
Amino-acid acetyltransferase		SHISO		443
Amino-acid acetyltransferase		SHIF2		443
Amino-acid acetyltransferase		Shigella flexneri 4c		443
+1001

Protein	Similar proteins		Species	Score	Length
P0A6C5	Amino-acid acetyltransferase		SHIFL		443
Amino-acid acetyltransferase		Shigella flexneri 1235-66		443
Amino-acid acetyltransferase		SHISO		443
Amino-acid acetyltransferase		SHIF2		443
Amino-acid acetyltransferase		Shigella flexneri 4c		443
+2085

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00492 Genomic DNA Translation: CAA68547.1 AF008115 Genomic DNA Translation: AAC23443.1 AF008116 Genomic DNA Translation: AAC23444.1 AF008117 Genomic DNA Translation: AAC23445.1 AF008118 Genomic DNA Translation: AAC23446.1 AF008119 Genomic DNA Translation: AAC23447.1 U29581 Genomic DNA Translation: AAB40465.1 U00096 Genomic DNA Translation: AAC75857.1 AP009048 Genomic DNA Translation: BAE76887.1
PIRⁱ	A30372 XYECAA
NCBI Reference Sequences More...RefSeqⁱ	NP_417295.1, NC_000913.3 WP_000237947.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0A6C5
SMRⁱ	P0A6C5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4262306, 14 interactors
Database of interacting proteins More...DIPⁱ	DIP-48037N
IntActⁱ	P0A6C5, 3 interactors
STRINGⁱ	316385.ECDH10B_2988

Proteomic databases

PaxDbⁱ	P0A6C5
PRIDEⁱ	P0A6C5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75857; AAC75857; b2818 BAE76887; BAE76887; BAE76887
GeneIDⁱ	947289
KEGGⁱ	ecj:JW2786 eco:b2818
PATRICⁱ	fig\|1411691.4.peg.3918

Organism-specific databases

EchoBASEⁱ	EB0061
EcoGeneⁱ	EG10063 argA

Phylogenomic databases

eggNOGⁱ	ENOG4108EKC Bacteria COG0548 LUCA COG1246 LUCA
InParanoidⁱ	P0A6C5
KEGG Orthology (KO) More...KOⁱ	K14682
OMAⁱ	KRKYNWD
PhylomeDBⁱ	P0A6C5

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00106
BioCycⁱ	EcoCyc:N-ACETYLTRANSFER-MONOMER MetaCyc:N-ACETYLTRANSFER-MONOMER
BRENDAⁱ	2.3.1.1 2026

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0A6C5

PROⁱ

PR:P0A6C5

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04237 AAK_NAGS-ABP, 1 hit
Gene3Dⁱ	3.40.1160.10, 1 hit
HAMAPⁱ	MF_01105 N_acetyl_glu_synth, 1 hit
InterProⁱ	View protein in InterPro IPR036393 AceGlu_kinase-like_sf IPR016181 Acyl_CoA_acyltransferase IPR001048 Asp/Glu/Uridylate_kinase IPR000182 GNAT_dom IPR033719 NAGS_kin IPR010167 NH2A_AcTrfase
PANTHERⁱ	PTHR30602 PTHR30602, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00696 AA_kinase, 1 hit PF00583 Acetyltransf_1, 1 hit
PIRSFⁱ	PIRSF000423 ArgA, 1 hit
SUPFAMⁱ	SSF53633 SSF53633, 1 hit SSF55729 SSF55729, 1 hit
TIGRFAMsⁱ	TIGR01890 N-Ac-Glu-synth, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARGA_ECOLI
Accessionⁱ	P0A6C5Primary (citable) accession number: P0A6C5 Secondary accession number(s): O68009 Q2MA19
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	March 28, 2018
	This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A6C5 (ARGA_ECOLI)

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Amino-acid acetyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Enzyme regulationⁱ

Pathwayⁱ: L-arginine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ