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Entry version 115 (13 Nov 2019)
Sequence version 1 (01 Aug 1988)
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Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The mutant strains shown below are all feedback-resistant (fbr) strains exhibiting enhanced arginine biosynthesis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Feedback inhibition by L-arginine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.1 Publication
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA), Amino-acid acetyltransferase (argA), Amino-acid acetyltransferase (argA), Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB), Acetylglutamate kinase (argB), Acetylglutamate kinase (argB), Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD), Acetylornithine/succinyldiaminopimelate aminotransferase (argD), Acetylornithine/succinyldiaminopimelate aminotransferase (argD), Acetylornithine/succinyldiaminopimelate aminotransferase (argD), Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:N-ACETYLTRANSFER-MONOMER
ECOL316407:JW2786-MONOMER
MetaCyc:N-ACETYLTRANSFER-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.1 2026

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00068;UER00106

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amino-acid acetyltransferase (EC:2.3.1.1)
Alternative name(s):
N-acetylglutamate synthase
Short name:
AGS
Short name:
NAGS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:argA
Ordered Locus Names:b2818, JW2786
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15H → Y in EE17. 1 Publication1
Mutagenesisi19Y → C in EE51. 1 Publication1
Mutagenesisi54S → N in PT2M217. 1 Publication1
Mutagenesisi58R → H in EE11. 1 Publication1
Mutagenesisi287G → S in PT2M216. 1 Publication1
Mutagenesisi432Q → R in PT2M217. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001867901 – 443Amino-acid acetyltransferaseAdd BLAST443

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0A6C5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A6C5

PRoteomics IDEntifications database

More...
PRIDEi
P0A6C5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4262306, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-48037N

Protein interaction database and analysis system

More...
IntActi
P0A6C5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2818

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A6C5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini296 – 443N-acetyltransferaseAdd BLAST148

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108EKC Bacteria
COG0548 LUCA
COG1246 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A6C5

KEGG Orthology (KO)

More...
KOi
K14682

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0A6C5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04237 AAK_NAGS-ABP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1160.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01105 N_acetyl_glu_synth, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR016181 Acyl_CoA_acyltransferase
IPR001048 Asp/Glu/Uridylate_kinase
IPR000182 GNAT_dom
IPR033719 NAGS_kin
IPR010167 NH2A_AcTrfase

The PANTHER Classification System

More...
PANTHERi
PTHR30602 PTHR30602, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00696 AA_kinase, 1 hit
PF00583 Acetyltransf_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000423 ArgA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53633 SSF53633, 1 hit
SSF55729 SSF55729, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01890 N-Ac-Glu-synth, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51186 GNAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A6C5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHE NFSSIVNDIG
60 70 80 90 100
LLHSLGIRLV VVYGARPQID ANLAAHHHEP LYHKNIRVTD AKTLELVKQA
110 120 130 140 150
AGTLQLDITA RLSMSLNNTP LQGAHINVVS GNFIIAQPLG VDDGVDYCHS
160 170 180 190 200
GRIRRIDEDA IHRQLDSGAI VLMGPVAVSV TGESFNLTSE EIATQLAIKL
210 220 230 240 250
KAEKMIGFCS SQGVTNDDGD IVSELFPNEA QARVEAQEEK GDYNSGTVRF
260 270 280 290 300
LRGAVKACRS GVRRCHLISY QEDGALLQEL FSRDGIGTQI VMESAEQIRR
310 320 330 340 350
ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNTTIACA
360 370 380 390 400
ALYPFPEEKI GEMACVAVHP DYRSSSRGEV LLERIAAQAK QSGLSKLFVL
410 420 430 440
TTRSIHWFQE RGFTPVDIDL LPESKKQLYN YQRKSKVLMA DLG
Length:443
Mass (Da):49,195
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE0D84902456797A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00492 Genomic DNA Translation: CAA68547.1
AF008115 Genomic DNA Translation: AAC23443.1
AF008116 Genomic DNA Translation: AAC23444.1
AF008117 Genomic DNA Translation: AAC23445.1
AF008118 Genomic DNA Translation: AAC23446.1
AF008119 Genomic DNA Translation: AAC23447.1
U29581 Genomic DNA Translation: AAB40465.1
U00096 Genomic DNA Translation: AAC75857.1
AP009048 Genomic DNA Translation: BAE76887.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A30372 XYECAA

NCBI Reference Sequences

More...
RefSeqi
NP_417295.1, NC_000913.3
WP_000237947.1, NZ_SSUV01000026.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75857; AAC75857; b2818
BAE76887; BAE76887; BAE76887

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2786
eco:b2818

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3918

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00492 Genomic DNA Translation: CAA68547.1
AF008115 Genomic DNA Translation: AAC23443.1
AF008116 Genomic DNA Translation: AAC23444.1
AF008117 Genomic DNA Translation: AAC23445.1
AF008118 Genomic DNA Translation: AAC23446.1
AF008119 Genomic DNA Translation: AAC23447.1
U29581 Genomic DNA Translation: AAB40465.1
U00096 Genomic DNA Translation: AAC75857.1
AP009048 Genomic DNA Translation: BAE76887.1
PIRiA30372 XYECAA
RefSeqiNP_417295.1, NC_000913.3
WP_000237947.1, NZ_SSUV01000026.1

3D structure databases

SMRiP0A6C5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4262306, 14 interactors
DIPiDIP-48037N
IntActiP0A6C5, 3 interactors
STRINGi511145.b2818

Proteomic databases

jPOSTiP0A6C5
PaxDbiP0A6C5
PRIDEiP0A6C5

Genome annotation databases

EnsemblBacteriaiAAC75857; AAC75857; b2818
BAE76887; BAE76887; BAE76887
GeneIDi947289
KEGGiecj:JW2786
eco:b2818
PATRICifig|1411691.4.peg.3918

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0061

Phylogenomic databases

eggNOGiENOG4108EKC Bacteria
COG0548 LUCA
COG1246 LUCA
InParanoidiP0A6C5
KOiK14682
PhylomeDBiP0A6C5

Enzyme and pathway databases

UniPathwayiUPA00068;UER00106
BioCyciEcoCyc:N-ACETYLTRANSFER-MONOMER
ECOL316407:JW2786-MONOMER
MetaCyc:N-ACETYLTRANSFER-MONOMER
BRENDAi2.3.1.1 2026

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0A6C5

Family and domain databases

CDDicd04237 AAK_NAGS-ABP, 1 hit
Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01105 N_acetyl_glu_synth, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR016181 Acyl_CoA_acyltransferase
IPR001048 Asp/Glu/Uridylate_kinase
IPR000182 GNAT_dom
IPR033719 NAGS_kin
IPR010167 NH2A_AcTrfase
PANTHERiPTHR30602 PTHR30602, 1 hit
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF00583 Acetyltransf_1, 1 hit
PIRSFiPIRSF000423 ArgA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01890 N-Ac-Glu-synth, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARGA_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A6C5
Secondary accession number(s): O68009
, O68010, O68011, O68012, O68013, P08205, Q2MA19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 13, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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