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Entry version 116 (18 Sep 2019)
Sequence version 1 (07 Jun 2005)
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Protein

Alanine racemase, biosynthetic

Gene

alr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.31 mM for D-alanine1 Publication
  2. KM=1.00 mM for L-alanine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: D-alanine biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.1 Publication
    Proteins known to be involved in this subpathway in this organism are:
    1. Alanine racemase (alr), Alanine racemase, biosynthetic (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr)
    This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

    Pathwayi: peptidoglycan biosynthesis

    This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.1 Publication
    View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei129Substrate1 Publication1
    Active sitei255Proton acceptor; specific for L-alanineUniRule annotation1
    Binding sitei303Substrate; via amide nitrogen1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase
    Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
    LigandPyridoxal phosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:ALARACEBIOSYN-MONOMER
    ECOL316407:JW4013-MONOMER
    MetaCyc:ALARACEBIOSYN-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    5.1.1.1 2026

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P0A6B4

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00042;UER00497
    UPA00219

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alanine racemase, biosynthetic1 Publication (EC:5.1.1.11 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:alr2 Publications
    Ordered Locus Names:b4053, JW4013
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    Escherichia coli strain K12 genome database

    More...
    EcoGenei
    EG10001 alr

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi164D → A: Slightly reduces affinity for D-Ala and L-Ala. 1 Publication1
    Mutagenesisi164D → K: Reduces catalytic activity. Slightly reduces affinity for D-Ala and L-Ala. 1 Publication1
    Mutagenesisi165E → A: Slightly reduces affinity for D-Ala and L-Ala. 1 Publication1
    Mutagenesisi165E → K: Reduces catalytic activity. Slightly reduces affinity for D-Ala and L-Ala. 1 Publication1
    Mutagenesisi219P → A: No effect on catalytic activity. No effect on affinity for D-Ala and L-Ala. 1 Publication1
    Mutagenesisi221E → A, K or P: Slightly increases catalytic activity. Slightly increases affinity for D-Ala and L-Ala. 1 Publication1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2833

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001145141 – 359Alanine racemase, biosyntheticAdd BLAST359

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34N6-(pyridoxal phosphate)lysine1 Publication1
    Modified residuei122N6-carboxylysine1 Publication1

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P0A6B4

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P0A6B4

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4260823, 598 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P0A6B4, 6 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4053

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P0A6B4

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1359
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P0A6B4

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P0A6B4

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CJ4 Bacteria
    COG0787 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000031446

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P0A6B4

    KEGG Orthology (KO)

    More...
    KOi
    K01775

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P0A6B4

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.37.10, 1 hit
    3.20.20.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01201 Ala_racemase, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000821 Ala_racemase
    IPR009006 Ala_racemase/Decarboxylase_C
    IPR011079 Ala_racemase_C
    IPR001608 Ala_racemase_N
    IPR020622 Ala_racemase_pyridoxalP-BS
    IPR029066 PLP-binding_barrel

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00842 Ala_racemase_C, 1 hit
    PF01168 Ala_racemase_N, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00992 ALARACEMASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01005 Ala_racemase_C, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50621 SSF50621, 1 hit
    SSF51419 SSF51419, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00492 alr, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00395 ALANINE_RACEMASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P0A6B4-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MQAATVVINR RALRHNLQRL RELAPASKMV AVVKANAYGH GLLETARTLP
    60 70 80 90 100
    DADAFGVARL EEALRLRAGG ITKPVLLLEG FFDARDLPTI SAQHFHTAVH
    110 120 130 140 150
    NEEQLAALEE ASLDEPVTVW MKLDTGMHRL GVRPEQAEAF YHRLTQCKNV
    160 170 180 190 200
    RQPVNIVSHF ARADEPKCGA TEKQLAIFNT FCEGKPGQRS IAASGGILLW
    210 220 230 240 250
    PQSHFDWVRP GIILYGVSPL EDRSTGADFG CQPVMSLTSS LIAVREHKAG
    260 270 280 290 300
    EPVGYGGTWV SERDTRLGVV AMGYGDGYPR AAPSGTPVLV NGREVPIVGR
    310 320 330 340 350
    VAMDMICVDL GPQAQDKAGD PVILWGEGLP VERIAEMTKV SAYELITRLT

    SRVAMKYVD
    Length:359
    Mass (Da):39,153
    Last modified:June 7, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDE9B438115342C2
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U00006 Genomic DNA Translation: AAC43147.1
    U00096 Genomic DNA Translation: AAC77023.1
    AP009048 Genomic DNA Translation: BAE78055.1
    K01174 Genomic DNA No translation available.
    M12047 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    D65213 PC1296

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418477.1, NC_000913.3
    WP_001147328.1, NZ_STEB01000022.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC77023; AAC77023; b4053
    BAE78055; BAE78055; BAE78055

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948564

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW4013
    eco:b4053

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2654

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U00006 Genomic DNA Translation: AAC43147.1
    U00096 Genomic DNA Translation: AAC77023.1
    AP009048 Genomic DNA Translation: BAE78055.1
    K01174 Genomic DNA No translation available.
    M12047 Genomic DNA No translation available.
    PIRiD65213 PC1296
    RefSeqiNP_418477.1, NC_000913.3
    WP_001147328.1, NZ_STEB01000022.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2RJGX-ray2.40A/B/C/D1-359[»]
    2RJHX-ray2.40A/B/C/D1-359[»]
    3B8TX-ray3.00A/B/C/D1-359[»]
    3B8UX-ray3.00A/B/C/D1-359[»]
    3B8VX-ray2.60A/B/C/D1-359[»]
    3B8WX-ray2.70A/B/C/D1-359[»]
    4WR3X-ray1.90A/B/C/D1-359[»]
    4XBJX-ray2.25A/B/C/D1-359[»]
    SMRiP0A6B4
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi4260823, 598 interactors
    IntActiP0A6B4, 6 interactors
    STRINGi511145.b4053

    Chemistry databases

    BindingDBiP0A6B4
    ChEMBLiCHEMBL2833

    Proteomic databases

    PaxDbiP0A6B4
    PRIDEiP0A6B4

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAC77023; AAC77023; b4053
    BAE78055; BAE78055; BAE78055
    GeneIDi948564
    KEGGiecj:JW4013
    eco:b4053
    PATRICifig|1411691.4.peg.2654

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0001
    EcoGeneiEG10001 alr

    Phylogenomic databases

    eggNOGiENOG4105CJ4 Bacteria
    COG0787 LUCA
    HOGENOMiHOG000031446
    InParanoidiP0A6B4
    KOiK01775
    PhylomeDBiP0A6B4

    Enzyme and pathway databases

    UniPathwayiUPA00042;UER00497
    UPA00219
    BioCyciEcoCyc:ALARACEBIOSYN-MONOMER
    ECOL316407:JW4013-MONOMER
    MetaCyc:ALARACEBIOSYN-MONOMER
    BRENDAi5.1.1.1 2026
    SABIO-RKiP0A6B4

    Miscellaneous databases

    EvolutionaryTraceiP0A6B4

    Protein Ontology

    More...
    PROi
    PR:P0A6B4

    Family and domain databases

    Gene3Di2.40.37.10, 1 hit
    3.20.20.10, 1 hit
    HAMAPiMF_01201 Ala_racemase, 1 hit
    InterProiView protein in InterPro
    IPR000821 Ala_racemase
    IPR009006 Ala_racemase/Decarboxylase_C
    IPR011079 Ala_racemase_C
    IPR001608 Ala_racemase_N
    IPR020622 Ala_racemase_pyridoxalP-BS
    IPR029066 PLP-binding_barrel
    PfamiView protein in Pfam
    PF00842 Ala_racemase_C, 1 hit
    PF01168 Ala_racemase_N, 1 hit
    PRINTSiPR00992 ALARACEMASE
    SMARTiView protein in SMART
    SM01005 Ala_racemase_C, 1 hit
    SUPFAMiSSF50621 SSF50621, 1 hit
    SSF51419 SSF51419, 1 hit
    TIGRFAMsiTIGR00492 alr, 1 hit
    PROSITEiView protein in PROSITE
    PS00395 ALANINE_RACEMASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALR1_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A6B4
    Secondary accession number(s): P29743, P78136, Q2M6Q1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: September 18, 2019
    This is version 116 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
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