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Protein

Acyl carrier protein

Gene

acpP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • acyl binding Source: EcoliWiki
  • acyl carrier activity Source: EcoliWiki
  • lipid binding Source: CAFA
  • phosphopantetheine binding Source: EcoliWiki

GO - Biological processi

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG50003-MONOMER
MetaCyc:EG50003-MONOMER
UniPathwayi
UPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Short name:
ACPUniRule annotation
Alternative name(s):
Cytosolic-activating factor
Short name:
CAF
Fatty acid synthase acyl carrier protein
Gene namesi
Name:acpPUniRule annotation
Ordered Locus Names:b1094, JW1080
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG50003 acpP

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi37S → A or T: Loss of phosphopantetheinylation, and inhibition of cell growth. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3309006
DrugBankiDB04450 Heptyl 1-Thiohexopyranoside

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001801342 – 78Acyl carrier proteinAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

EPDiP0A6A8
PaxDbiP0A6A8
PRIDEiP0A6A8

Interactioni

Subunit structurei

Interacts with MukB.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi4263360, 495 interactors
DIPiDIP-29374N
IntActiP0A6A8, 45 interactors
STRINGi316385.ECDH10B_1166

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A6A8
SMRiP0A6A8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6A8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77CarrierPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0236 LUCA
HOGENOMiHOG000178184
InParanoidiP0A6A8
KOiK02078
PhylomeDBiP0A6A8

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A6A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTIEERVKK IIGEQLGVKQ EEVTNNASFV EDLGADSLDT VELVMALEEE
60 70
FDTEIPDEEA EKITTVQAAI DYINGHQA
Length:78
Mass (Da):8,640
Last modified:January 23, 2007 - v2
Checksum:i41FCFC39D45BFEA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25N → D AA sequence (PubMed:4882207).Curated1
Sequence conflicti44V → I AA sequence (PubMed:3549687).Curated1
Sequence conflicti71D → V in AAB27925 (PubMed:8359454).Curated1
Sequence conflicti76H → N in AAB27925 (PubMed:8359454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84991 Genomic DNA Translation: AAA23740.1
S65033 Genomic DNA Translation: AAB27925.2
U00096 Genomic DNA Translation: AAC74178.1
AP009048 Genomic DNA Translation: BAA35902.1
Z34979 Genomic DNA No translation available.
PIRiC42147 AYEC
RefSeqiNP_415612.1, NC_000913.3
WP_000103754.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74178; AAC74178; b1094
BAA35902; BAA35902; BAA35902
GeneIDi35809147
944805
KEGGiecj:JW1080
eco:b1094
PATRICifig|1411691.4.peg.1174

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84991 Genomic DNA Translation: AAA23740.1
S65033 Genomic DNA Translation: AAB27925.2
U00096 Genomic DNA Translation: AAC74178.1
AP009048 Genomic DNA Translation: BAA35902.1
Z34979 Genomic DNA No translation available.
PIRiC42147 AYEC
RefSeqiNP_415612.1, NC_000913.3
WP_000103754.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ACPNMR-A2-78[»]
1L0HX-ray2.00A1-77[»]
1L0IX-ray1.20A1-78[»]
1T8KX-ray1.10A2-78[»]
2FACX-ray1.76A/B2-78[»]
2FADX-ray1.60A/B2-78[»]
2FAEX-ray1.55A/B2-78[»]
2FHSX-ray2.70C1-78[»]
2K92NMR-A2-78[»]
2K93NMR-A2-78[»]
2K94NMR-A2-78[»]
3EJBX-ray2.00A/C/E/G1-78[»]
3EJDX-ray2.10A/C/E/G1-78[»]
3EJEX-ray2.10A/C/E/G1-78[»]
3NY7X-ray1.92B1-78[»]
5KOFX-ray2.40C/D1-78[»]
5USRX-ray3.09I/J/K/L1-78[»]
5VCBX-ray4.10D/E/F/J/K/L/P/Q/R/V/W/X/d/e/f2-78[»]
5WGBX-ray2.75C2-78[»]
5WKPX-ray3.15C/G2-78[»]
ProteinModelPortaliP0A6A8
SMRiP0A6A8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263360, 495 interactors
DIPiDIP-29374N
IntActiP0A6A8, 45 interactors
STRINGi316385.ECDH10B_1166

Chemistry databases

ChEMBLiCHEMBL3309006
DrugBankiDB04450 Heptyl 1-Thiohexopyranoside

Proteomic databases

EPDiP0A6A8
PaxDbiP0A6A8
PRIDEiP0A6A8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74178; AAC74178; b1094
BAA35902; BAA35902; BAA35902
GeneIDi35809147
944805
KEGGiecj:JW1080
eco:b1094
PATRICifig|1411691.4.peg.1174

Organism-specific databases

EchoBASEiEB4297
EcoGeneiEG50003 acpP

Phylogenomic databases

eggNOGiCOG0236 LUCA
HOGENOMiHOG000178184
InParanoidiP0A6A8
KOiK02078
PhylomeDBiP0A6A8

Enzyme and pathway databases

UniPathwayi
UPA00094

BioCyciEcoCyc:EG50003-MONOMER
MetaCyc:EG50003-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A6A8
PROiPR:P0A6A8

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACP_ECOLI
AccessioniPrimary (citable) accession number: P0A6A8
Secondary accession number(s): P02901, Q53352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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