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UniProtKB - P0A6A0 (UBIB_ECOLI)
Protein
Probable protein kinase UbiB
Gene
ubiB
Organism
Escherichia coli (strain K12)
Status
Functioni
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
UniRule annotation2 Publications: ubiquinone biosynthesis Pathwayi
This protein regulates the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 153 | ATPUniRule annotation | 1 | |
Active sitei | 288 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 130 – 138 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: GO_Central
GO - Biological processi
- regulation of ubiquinone biosynthetic process Source: UniProtKB-UniRule
- ubiquinone biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Ubiquinone biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:2-OCTAPRENYLPHENOL-HYDROX-MONOMER |
UniPathwayi | UPA00232 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable protein kinase UbiBUniRule annotation (EC:2.7.-.-UniRule annotation)Alternative name(s): Ubiquinone biosynthesis protein UbiBUniRule annotation |
Gene namesi | Name:ubiBUniRule annotation Synonyms:aarF, yigQ, yigR, yigS Ordered Locus Names:b3835, JW3812 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 501 – 521 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 522 – 542 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Cells lacking this gene fail to produce coenzyme Q8, and accumulate octaprenylphenol (OPP).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200703 | 1 – 546 | Probable protein kinase UbiBAdd BLAST | 546 |
Proteomic databases
jPOSTi | P0A6A0 |
PaxDbi | P0A6A0 |
PRIDEi | P0A6A0 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260948, 361 interactors |
DIPi | DIP-35858N |
IntActi | P0A6A0, 13 interactors |
STRINGi | 511145.b3835 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 502 | Protein kinaseUniRule annotationAdd BLAST | 379 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0661, Bacteria |
HOGENOMi | CLU_006533_0_0_6 |
InParanoidi | P0A6A0 |
PhylomeDBi | P0A6A0 |
Family and domain databases
CDDi | cd13972, UbiB, 1 hit |
HAMAPi | MF_00414, UbiB, 1 hit |
InterProi | View protein in InterPro IPR004147, ABC1_dom IPR011009, Kinase-like_dom_sf IPR010232, UbiB IPR045308, UbiB_bact |
Pfami | View protein in Pfam PF03109, ABC1, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
TIGRFAMsi | TIGR01982, UbiB, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A6A0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPGEVRRLY FIIRTFLSYG LDELIPKMRI TLPLRLWRYS LFWMPNRHKD
60 70 80 90 100
KLLGERLRLA LQELGPVWIK FGQMLSTRRD LFPPHIADQL ALLQDKVAPF
110 120 130 140 150
DGKLAKQQIE AAMGGLPVEA WFDDFEIKPL ASASIAQVHT ARLKSNGKEV
160 170 180 190 200
VIKVIRPDIL PVIKADLKLI YRLARWVPRL LPDGRRLRPT EVVREYEKTL
210 220 230 240 250
IDELNLLRES ANAIQLRRNF EDSPMLYIPE VYPDYCSEGM MVMERIYGIP
260 270 280 290 300
VSDVAALEKN GTNMKLLAER GVQVFFTQVF RDSFFHADMH PGNIFVSYEH
310 320 330 340 350
PENPKYIGID CGIVGSLNKE DKRYLAENFI AFFNRDYRKV AELHVDSGWV
360 370 380 390 400
PPDTNVEEFE FAIRTVCEPI FEKPLAEISF GHVLLNLFNT ARRFNMEVQP
410 420 430 440 450
QLVLLQKTLL YVEGVGRQLY PQLDLWKTAK PFLESWIKDQ VGIPALVRAF
460 470 480 490 500
KEKAPFWVEK MPELPELVYD SLRQGKYLQH SVDKIARELQ SNHVRQGQSR
510 520 530 540
YFLGIGATLV LSGTFLLVSR PEWGLMPGWL MAGGLIAWFV GWRKTR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 525 | L → V in X05967 (PubMed:3309887).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87049 Genomic DNA Translation: AAA67630.2 Frameshift. M87049 Genomic DNA Translation: AAA67631.1 Frameshift. M87049 Genomic DNA Translation: AAA67632.1 Frameshift. U00096 Genomic DNA Translation: AAC76838.1 AP009048 Genomic DNA Translation: BAE77466.1 X05967 Genomic DNA No translation available. |
PIRi | D65188 |
RefSeqi | NP_418279.1, NC_000913.3 WP_000187530.1, NZ_STEB01000021.1 |
Genome annotation databases
EnsemblBacteriai | AAC76838; AAC76838; b3835 BAE77466; BAE77466; BAE77466 |
GeneIDi | 66672257 948322 |
KEGGi | ecj:JW3812 eco:b3835 |
PATRICi | fig|1411691.4.peg.2873 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87049 Genomic DNA Translation: AAA67630.2 Frameshift. M87049 Genomic DNA Translation: AAA67631.1 Frameshift. M87049 Genomic DNA Translation: AAA67632.1 Frameshift. U00096 Genomic DNA Translation: AAC76838.1 AP009048 Genomic DNA Translation: BAE77466.1 X05967 Genomic DNA No translation available. |
PIRi | D65188 |
RefSeqi | NP_418279.1, NC_000913.3 WP_000187530.1, NZ_STEB01000021.1 |
3D structure databases
SMRi | P0A6A0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260948, 361 interactors |
DIPi | DIP-35858N |
IntActi | P0A6A0, 13 interactors |
STRINGi | 511145.b3835 |
Proteomic databases
jPOSTi | P0A6A0 |
PaxDbi | P0A6A0 |
PRIDEi | P0A6A0 |
Protocols and materials databases
DNASUi | 948322 |
Genome annotation databases
EnsemblBacteriai | AAC76838; AAC76838; b3835 BAE77466; BAE77466; BAE77466 |
GeneIDi | 66672257 948322 |
KEGGi | ecj:JW3812 eco:b3835 |
PATRICi | fig|1411691.4.peg.2873 |
Organism-specific databases
EchoBASEi | EB1443 |
Phylogenomic databases
eggNOGi | COG0661, Bacteria |
HOGENOMi | CLU_006533_0_0_6 |
InParanoidi | P0A6A0 |
PhylomeDBi | P0A6A0 |
Enzyme and pathway databases
UniPathwayi | UPA00232 |
BioCyci | EcoCyc:2-OCTAPRENYLPHENOL-HYDROX-MONOMER |
Miscellaneous databases
PROi | PR:P0A6A0 |
Family and domain databases
CDDi | cd13972, UbiB, 1 hit |
HAMAPi | MF_00414, UbiB, 1 hit |
InterProi | View protein in InterPro IPR004147, ABC1_dom IPR011009, Kinase-like_dom_sf IPR010232, UbiB IPR045308, UbiB_bact |
Pfami | View protein in Pfam PF03109, ABC1, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
TIGRFAMsi | TIGR01982, UbiB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIB_ECOLI | |
Accessioni | P0A6A0Primary (citable) accession number: P0A6A0 Secondary accession number(s): P27853 Q2M8E0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families