Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UvrABC system protein A

Gene

uvrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Miscellaneous

Binds about 2 zinc atoms/molecule.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATP8
Zinc fingeri253 – 280C4-typeUniRule annotationAdd BLAST28
Nucleotide bindingi640 – 647ATP8
Zinc fingeri740 – 766C4-typeUniRule annotationAdd BLAST27

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-UniRule
  • DNA binding Source: EcoCyc
  • excinuclease ABC activity Source: UniProtKB-UniRule
  • identical protein binding Source: IntAct
  • zinc ion binding Source: UniProtKB-UniRule

GO - Biological processi

  • DNA repair Source: EcoCyc
  • nucleotide-excision repair Source: UniProtKB-UniRule
  • response to radiation Source: EcoCyc
  • SOS response Source: UniProtKB-UniRule

Keywordsi

Molecular functionDNA-binding, Excision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11061-MONOMER
MetaCyc:EG11061-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Synonyms:dinE
Ordered Locus Names:b4058, JW4019
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11061 uvrA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi253C → A, H or S: Reduced activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000930491 – 940UvrABC system protein AAdd BLAST940

Proteomic databases

EPDiP0A698
PaxDbiP0A698
PRIDEiP0A698

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions (By similarity). Interacts with TRCF (Mfd). UvrB and TRCF binding to UvrA could be mutually exclusive.UniRule annotation1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4262670, 52 interactors
852853, 1 interactor
ComplexPortaliCPX-2151 UvrAB complex
CPX-2155 TRCF-UvrA complex
DIPiDIP-35876N
IntActiP0A698, 17 interactors
STRINGi316407.85676810

Structurei

Secondary structure

1940
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A698
SMRiP0A698
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 587ABC transporter 1UniRule annotationAdd BLAST278
Domaini607 – 937ABC transporter 2UniRule annotationAdd BLAST331

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri253 – 280C4-typeUniRule annotationAdd BLAST28
Zinc fingeri740 – 766C4-typeUniRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG4105C5U Bacteria
COG0178 LUCA
HOGENOMiHOG000050448
InParanoidiP0A698
KOiK03701
PhylomeDBiP0A698

Family and domain databases

HAMAPiMF_00205 UvrA, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR004602 UvrA
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A698-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKIEVRGAR THNLKNINLV IPRDKLIVVT GLSGSGKSSL AFDTLYAEGQ
60 70 80 90 100
RRYVESLSAY ARQFLSLMEK PDVDHIEGLS PAISIEQKST SHNPRSTVGT
110 120 130 140 150
ITEIHDYLRL LFARVGEPRC PDHDVPLAAQ TVSQMVDNVL SQPEGKRLML
160 170 180 190 200
LAPIIKERKG EHTKTLENLA SQGYIRARID GEVCDLSDPP KLELQKKHTI
210 220 230 240 250
EVVVDRFKVR DDLTQRLAES FETALELSGG TAVVADMDDP KAEELLFSAN
260 270 280 290 300
FACPICGYSM RELEPRLFSF NNPAGACPTC DGLGVQQYFD PDRVIQNPEL
310 320 330 340 350
SLAGGAIRGW DRRNFYYFQM LKSLADHYKF DVEAPWGSLS ANVHKVVLYG
360 370 380 390 400
SGKENIEFKY MNDRGDTSIR RHPFEGVLHN MERRYKETES SAVREELAKF
410 420 430 440 450
ISNRPCASCE GTRLRREARH VYVENTPLPA ISDMSIGHAM EFFNNLKLAG
460 470 480 490 500
QRAKIAEKIL KEIGDRLKFL VNVGLNYLTL SRSAETLSGG EAQRIRLASQ
510 520 530 540 550
IGAGLVGVMY VLDEPSIGLH QRDNERLLGT LIHLRDLGNT VIVVEHDEDA
560 570 580 590 600
IRAADHVIDI GPGAGVHGGE VVAEGPLEAI MAVPESLTGQ YMSGKRKIEV
610 620 630 640 650
PKKRVPANPE KVLKLTGARG NNLKDVTLTL PVGLFTCITG VSGSGKSTLI
660 670 680 690 700
NDTLFPIAQR QLNGATIAEP APYRDIQGLE HFDKVIDIDQ SPIGRTPRSN
710 720 730 740 750
PATYTGVFTP VRELFAGVPE SRARGYTPGR FSFNVRGGRC EACQGDGVIK
760 770 780 790 800
VEMHFLPDIY VPCDQCKGKR YNRETLEIKY KGKTIHEVLD MTIEEAREFF
810 820 830 840 850
DAVPALARKL QTLMDVGLTY IRLGQSATTL SGGEAQRVKL ARELSKRGTG
860 870 880 890 900
QTLYILDEPT TGLHFADIQQ LLDVLHKLRD QGNTIVVIEH NLDVIKTADW
910 920 930 940
IVDLGPEGGS GGGEILVSGT PETVAECEAS HTARFLKPML
Length:940
Mass (Da):103,868
Last modified:April 1, 1988 - v1
Checksum:iD61AAEB6514B860C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13495 Genomic DNA Translation: AAA24754.1
U00006 Genomic DNA Translation: AAC43152.1
U00096 Genomic DNA Translation: AAC77028.1
AP009048 Genomic DNA Translation: BAE78060.1
X01621 Genomic DNA Translation: CAA25764.1
J01721 Genomic DNA Translation: AAA24753.1
PIRiA23869 BVECUA
RefSeqiNP_418482.1, NC_000913.3
WP_000357740.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77028; AAC77028; b4058
BAE78060; BAE78060; BAE78060
GeneIDi948559
KEGGiecj:JW4019
eco:b4058
PATRICifig|1411691.4.peg.2647

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13495 Genomic DNA Translation: AAA24754.1
U00006 Genomic DNA Translation: AAC43152.1
U00096 Genomic DNA Translation: AAC77028.1
AP009048 Genomic DNA Translation: BAE78060.1
X01621 Genomic DNA Translation: CAA25764.1
J01721 Genomic DNA Translation: AAA24753.1
PIRiA23869 BVECUA
RefSeqiNP_418482.1, NC_000913.3
WP_000357740.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DFCX-ray2.80B/D131-250[»]
ProteinModelPortaliP0A698
SMRiP0A698
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262670, 52 interactors
852853, 1 interactor
ComplexPortaliCPX-2151 UvrAB complex
CPX-2155 TRCF-UvrA complex
DIPiDIP-35876N
IntActiP0A698, 17 interactors
STRINGi316407.85676810

Proteomic databases

EPDiP0A698
PaxDbiP0A698
PRIDEiP0A698

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77028; AAC77028; b4058
BAE78060; BAE78060; BAE78060
GeneIDi948559
KEGGiecj:JW4019
eco:b4058
PATRICifig|1411691.4.peg.2647

Organism-specific databases

EchoBASEiEB1054
EcoGeneiEG11061 uvrA

Phylogenomic databases

eggNOGiENOG4105C5U Bacteria
COG0178 LUCA
HOGENOMiHOG000050448
InParanoidiP0A698
KOiK03701
PhylomeDBiP0A698

Enzyme and pathway databases

BioCyciEcoCyc:EG11061-MONOMER
MetaCyc:EG11061-MONOMER

Miscellaneous databases

PROiPR:P0A698

Family and domain databases

HAMAPiMF_00205 UvrA, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR004602 UvrA
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUVRA_ECOLI
AccessioniPrimary (citable) accession number: P0A698
Secondary accession number(s): P07671, P76788, Q2M6P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again