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Protein

ESAT-6-like protein EsxB

Gene

esxB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

A secreted protein. Acts as a strong host T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA.By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processVirulence

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-4099-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ESAT-6-like protein EsxB
Alternative name(s):
10 kDa culture filtrate antigen CFP-10
Secreted antigenic protein MTSA-10
Gene namesi
Name:esxB
Synonyms:cfp10, lhp, mtsA10
Ordered Locus Names:BQ2027_MB3904
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001677942 – 100ESAT-6-like protein EsxBAdd BLAST99

Interactioni

Subunit structurei

Forms a tight 1:1 complex with EsxA (ESAT-6).By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A567
SMRiP0A567
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A567

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 86Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the WXG100 family. CFP-10 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000073770
OMAiMVGQAGT

Family and domain databases

InterProiView protein in InterPro
IPR036689 ESAT-6-like_sf
IPR010310 T7SS_ESAT-6-like
PfamiView protein in Pfam
PF06013 WXG100, 1 hit
SUPFAMiSSF140453 SSF140453, 1 hit
TIGRFAMsiTIGR03930 WXG100_ESAT6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A567-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEMKTDAAT LAQEAGNFER ISGDLKTQID QVESTAGSLQ GQWRGAAGTA
60 70 80 90 100
AQAAVVRFQE AANKQKQELD EISTNIRQAG VQYSRADEEQ QQALSSQMGF
Length:100
Mass (Da):10,794
Last modified:January 23, 2007 - v2
Checksum:i285F4FC96F55D194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU02536.1
RefSeqiNP_857541.1, NC_002945.3
WP_003399940.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO45176; CDO45176; Mb3904
PATRICifig|233413.5.peg.4277

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU02536.1
RefSeqiNP_857541.1, NC_002945.3
WP_003399940.1, NC_002945.4

3D structure databases

ProteinModelPortaliP0A567
SMRiP0A567
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO45176; CDO45176; Mb3904
PATRICifig|233413.5.peg.4277

Phylogenomic databases

HOGENOMiHOG000073770
OMAiMVGQAGT

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-4099-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A567

Family and domain databases

InterProiView protein in InterPro
IPR036689 ESAT-6-like_sf
IPR010310 T7SS_ESAT-6-like
PfamiView protein in Pfam
PF06013 WXG100, 1 hit
SUPFAMiSSF140453 SSF140453, 1 hit
TIGRFAMsiTIGR03930 WXG100_ESAT6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESXB_MYCBO
AccessioniPrimary (citable) accession number: P0A567
Secondary accession number(s): A0A1R3Y5R0, O69739, X2BQ42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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