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Protein

Cadmium resistance transcriptional regulatory protein CadC

Gene

cadC

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Metal binding causes the repressor to dissociate from the DNA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Cadmium; shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi10Cadmium; shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi57Cadmium; shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi59Cadmium; shared with dimeric partnerPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 77H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCadmium resistance, Transcription, Transcription regulation
LigandCadmium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadmium resistance transcriptional regulatory protein CadC
Alternative name(s):
Cadmium efflux system accessory protein
Gene namesi
Name:cadC
Encoded oniPlasmid pND3021 Publication
Plasmid pAH821 Publication
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606171 – 119Cadmium resistance transcriptional regulatory protein CadCAdd BLAST119

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A4U3
SMRiP0A4U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 118HTH arsR-typePROSITE-ProRule annotationAdd BLAST96

Phylogenomic databases

HOGENOMiHOG000144506

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR018334 ArsR_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00846 HTH_ARSR_1, 1 hit
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A4U3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL
60 70 80 90 100
VHEDELCVCD IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN
110
IKILNLMELG VNFKEEVLA
Length:119
Mass (Da):13,382
Last modified:March 15, 2005 - v1
Checksum:iB34C01C21DC2C944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78967 Genomic DNA Translation: AAB37344.1
AF243383 Genomic DNA Translation: AAF98301.1
RefSeqiNP_862601.1, NC_004966.1
WP_003726380.1, NZ_OLME01000007.1
YP_001174713.1, NC_009435.1
YP_001966470.1, NC_010901.1
YP_004761536.1, NC_015863.1

Genome annotation databases

GeneIDi11013250
3125820
5077334
6385740

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78967 Genomic DNA Translation: AAB37344.1
AF243383 Genomic DNA Translation: AAF98301.1
RefSeqiNP_862601.1, NC_004966.1
WP_003726380.1, NZ_OLME01000007.1
YP_001174713.1, NC_009435.1
YP_001966470.1, NC_010901.1
YP_004761536.1, NC_015863.1

3D structure databases

ProteinModelPortaliP0A4U3
SMRiP0A4U3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11013250
3125820
5077334
6385740

Phylogenomic databases

HOGENOMiHOG000144506

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR018334 ArsR_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00846 HTH_ARSR_1, 1 hit
PS50987 HTH_ARSR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCADC_LACLL
AccessioniPrimary (citable) accession number: P0A4U3
Secondary accession number(s): P94887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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