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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Ordered Locus Names:gbs1231
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000823 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761451 – 217Uracil-DNA glycosylaseAdd BLAST217

Proteomic databases

PRIDEiP0A4P3

Structurei

3D structure databases

ProteinModelPortaliP0A4P3
SMRiP0A4P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A4P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHSSWHDLI KRELPNHYYN KINTFMDAVY ESGIVYPPRD KVFNAIQITP
60 70 80 90 100
LENVKVVIIG QDPYHGPQQA QGLSFSVPDN LPAPPSLQNI LKELAEDIGS
110 120 130 140 150
RSHHDLTSWA QQGVLLLNAC LTVPEHQANG HAGLIWEPFT DAVIKVVNQK
160 170 180 190 200
ETPVVFILWG GYARKKKSLI DNPIHHIIES PHPSPLSAYR GFFGSRPFSR
210
TNHFLEEEGI NEIDWLN
Length:217
Mass (Da):24,570
Last modified:March 15, 2005 - v1
Checksum:iEC6C29EF8732895B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766849 Genomic DNA Translation: CAD46890.1
RefSeqiWP_000682955.1, NC_004368.1

Genome annotation databases

EnsemblBacteriaiCAD46890; CAD46890; CAD46890
KEGGisan:ung

Similar proteinsi

Entry informationi

Entry nameiUNG_STRA3
AccessioniPrimary (citable) accession number: P0A4P3
Secondary accession number(s): Q9XDS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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