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UniProtKB - P0A4K4 (PMRA_STRPN)
Protein
Multi-drug resistance efflux pump PmrA
Gene
pmrA
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Functioni
Efflux pump for various substrates.
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.1.2.34, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Multi-drug resistance efflux pump PmrA |
Gene namesi | Name:pmrA Ordered Locus Names:SP_0972 |
Organismi | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Taxonomic identifieri | 170187 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 34 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 49 – 71 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 84 – 106 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 140 – 162 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 167 – 186 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 217 – 239 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 248 – 270 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 306 – 328 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 340 – 362 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 366 – 388 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173377 | 1 – 399 | Multi-drug resistance efflux pump PmrAAdd BLAST | 399 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
OMAi | IVAPLWG |
PhylomeDBi | P0A4K4 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A4K4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEINWKDNL RIAWFGNFLT GASISLVVPF MPIFVENLGV GSQQVAFYAG
60 70 80 90 100
LAISVSAISA ALFSPIWGIL ADKYGRKPMM IRAGLAMTIT MGGLAFVPNI
110 120 130 140 150
YWLIFLRLLN GVFAGFVPNA TALIASQVPK EKSGSALGTL STGVVAGTLT
160 170 180 190 200
GPFIGGFIAE LFGIRTVFLL VGSFLFLAAI LTICFIKEDF QPVAKEKAIP
210 220 230 240 250
TKELFTSVKY PYLLLNLFLT SFVIQFSAQS IGPILALYVR DLGQTENLLF
260 270 280 290 300
VSGLIVSSMG FSSMMSAGVM GKLGDKVGNH RLLVVAQFYS VIIYLLCANA
310 320 330 340 350
SSPLQLGLYR FLFGLGTGAL IPGVNALLSK MTPKAGISRV FAFNQVFFYL
360 370 380 390
GGVVGPMAGS AVAGQFGYHA VFYATSLCVA FSCLFNLIQF RTLLKVKEI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ007367 Genomic DNA Translation: CAA07482.1 AE005672 Genomic DNA Translation: AAK75093.1 |
PIRi | D95112 |
RefSeqi | WP_000136147.1, NZ_AKVY01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAK75093; AAK75093; SP_0972 |
GeneIDi | 60234173 |
KEGGi | spn:SP_0972 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ007367 Genomic DNA Translation: CAA07482.1 AE005672 Genomic DNA Translation: AAK75093.1 |
PIRi | D95112 |
RefSeqi | WP_000136147.1, NZ_AKVY01000001.1 |
3D structure databases
SMRi | P0A4K4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 170187.SP_0972 |
Protein family/group databases
TCDBi | 2.A.1.2.34, the major facilitator superfamily (mfs) |
Genome annotation databases
EnsemblBacteriai | AAK75093; AAK75093; SP_0972 |
GeneIDi | 60234173 |
KEGGi | spn:SP_0972 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
OMAi | IVAPLWG |
PhylomeDBi | P0A4K4 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PMRA_STRPN | |
Accessioni | P0A4K4Primary (citable) accession number: P0A4K4 Secondary accession number(s): Q9ZEX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |