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UniProtKB - P0A3S0 (NCZS_STRML)
Protein
Neocarzinostatin
Gene
ncsA
Organism
Streptomyces malayensis
Status
Functioni
NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: NeocarzinostatinShort name: NCS Alternative name(s): Mitomalcin Short name: MMC |
Gene namesi | Name:ncsA |
Organismi | Streptomyces malayensis |
Taxonomic identifieri | 1918 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213118 | 1 – 113 | NeocarzinostatinAdd BLAST | 113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 47 | By similarity | ||
Disulfide bondi | 88 ↔ 93 | By similarity |
Keywords - PTMi
Disulfide bondStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P0A3S0 |
BMRBi | P0A3S0 |
SMRi | P0A3S0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the neocarzinostatin family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR027273, Neocarzinostatin-like IPR002186, Neocarzinostatin_fam |
Pfami | View protein in Pfam PF00960, Neocarzinostat, 1 hit |
PRINTSi | PR01885, MACROMOMYCIN |
SUPFAMi | SSF49319, SSF49319, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A3S0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AAPTATVTPS SGLSDGTVVK VAGAGLQAGT AYDVGQCAWV DTGVLACNPA
60 70 80 90 100
DFSSVTADAN GSASTSLTVR RSFEGFLFDG TRWGTVDCTT AACQVGLSDA
110
AGNGPEGVAI SFN
Sequence databases
PIRi | B40278 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | B40278 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JW3 | X-ray | 2.60 | A/B | 1-112 | [»] | |
AlphaFoldDBi | P0A3S0 | |||||
BMRBi | P0A3S0 | |||||
SMRi | P0A3S0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB04408, Ncs-Chromophore |
Family and domain databases
InterProi | View protein in InterPro IPR027273, Neocarzinostatin-like IPR002186, Neocarzinostatin_fam |
Pfami | View protein in Pfam PF00960, Neocarzinostat, 1 hit |
PRINTSi | PR01885, MACROMOMYCIN |
SUPFAMi | SSF49319, SSF49319, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NCZS_STRML | |
Accessioni | P0A3S0Primary (citable) accession number: P0A3S0 Secondary accession number(s): P01550 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | March 15, 2005 | |
Last modified: | May 25, 2022 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families