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Protein

Pertussis toxin subunit 4

Gene

ptxD

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Enzyme and pathway databases

BioCyciBPER257313:BP3785-MONOMER

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family
UniLectiniP0A3R5

Names & Taxonomyi

Protein namesi
Recommended name:
Pertussis toxin subunit 4
Short name:
PTX S4
Alternative name(s):
Islet-activating protein S4
Short name:
IAP S4
Gene namesi
Name:ptxD
Ordered Locus Names:BP3785
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

Pathology & Biotechi

Keywords - Diseasei

Whooping cough

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Add BLAST42
ChainiPRO_000001936243 – 152Pertussis toxin subunit 4Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 93
Disulfide bondi145 ↔ 151

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Pertussis toxin contains five different chains, S1-S5. They are organized into 2 functional subunits: A, composed of S1 (which is toxic) and B, containing S2, S3, S5, and two copies of S4 (B binds to the membrane receptors). Dimers of S2-S4 and S3-S4 are held together by S5.

Protein-protein interaction databases

STRINGi257313.BP3785

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A3R5
SMRiP0A3R5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A3R5

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000095590
KOiK11026
OMAiYEVNPTR

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR015355 Pertussis_toxin_subS4
PfamiView protein in Pfam
PF09275 Pertus-S4-tox, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A3R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRFPTRTT APGQGGARRS RVRALAWLLA SGAMTHLSPA LADVPYVLVK
60 70 80 90 100
TNMVVTSVAM KPYEVTPTRM LVCGIAAKLG AAASSPDAHV PFCFGKDLKR
110 120 130 140 150
PGSSPMEVML RAVFMQQRPL RMFLGPKQLT FEGKPALELI RMVECSGKQD

CP
Length:152
Mass (Da):16,544
Last modified:August 13, 1987 - v1
Checksum:i04F135C32DA5DDA1
GO

Sequence cautioni

The sequence AAA22983 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83982.1
M13223 Genomic DNA Translation: AAA22983.1 Different initiation.
BX640422 Genomic DNA Translation: CAE44040.1
PIRiD24394 WEBR41
RefSeqiNP_882284.1, NC_002929.2
WP_010929491.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE44040; CAE44040; BP3785
GeneIDi2665406
KEGGibpe:BP3785
PATRICifig|257313.5.peg.4089

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14378 Genomic DNA Translation: AAA83982.1
M13223 Genomic DNA Translation: AAA22983.1 Different initiation.
BX640422 Genomic DNA Translation: CAE44040.1
PIRiD24394 WEBR41
RefSeqiNP_882284.1, NC_002929.2
WP_010929491.1, NC_002929.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCPX-ray2.70D/E/J/K43-152[»]
1PRTX-ray2.90D/E/J/K43-152[»]
1PTOX-ray3.50D/E/J/K43-152[»]
ProteinModelPortaliP0A3R5
SMRiP0A3R5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP3785

Protein family/group databases

TCDBi1.C.72.1.1 the pertussis toxin (ptx) family
UniLectiniP0A3R5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE44040; CAE44040; BP3785
GeneIDi2665406
KEGGibpe:BP3785
PATRICifig|257313.5.peg.4089

Phylogenomic databases

HOGENOMiHOG000095590
KOiK11026
OMAiYEVNPTR

Enzyme and pathway databases

BioCyciBPER257313:BP3785-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A3R5

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR015355 Pertussis_toxin_subS4
PfamiView protein in Pfam
PF09275 Pertus-S4-tox, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX4_BORPE
AccessioniPrimary (citable) accession number: P0A3R5
Secondary accession number(s): P04980
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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