UniProtKB - P0A3M6 (PBP2_STRR6)
Protein
Penicillin-binding protein 2B
Gene
penA
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 386 | Acyl-ester intermediateBy similarity | 1 |
GO - Molecular functioni
- penicillin binding Source: GO_Central
- peptidoglycan L,D-transpeptidase activity Source: GO_Central
GO - Biological processi
- cell wall organization Source: GO_Central
- peptidoglycan biosynthetic process Source: UniProtKB-KW
- regulation of cell shape Source: UniProtKB-KW
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Penicillin-binding protein 2B |
Gene namesi | Name:penA Synonyms:pbp2b Ordered Locus Names:spr1517 |
Organismi | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
Taxonomic identifieri | 171101 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
- Cell membrane By similarity; Single-pass membrane protein By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4296322 |
DrugBanki | DB01163, Amdinocillin DB00415, Ampicillin DB08795, Azidocillin DB01140, Cefadroxil DB00456, Cefalotin DB01066, Cefditoren DB00493, Cefotaxime DB01331, Cefoxitin DB01212, Ceftriaxone DB00567, Cephalexin DB03313, Cephalosporin C DB00485, Dicloxacillin DB00739, Hetacillin DB01603, Meticillin DB00607, Nafcillin DB00713, Oxacillin DB00319, Piperacillin |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195456 | 1 – 680 | Penicillin-binding protein 2BAdd BLAST | 680 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A3M6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A3M6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the transpeptidase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0768, Bacteria |
HOGENOMi | CLU_009289_7_0_9 |
Family and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR005311, PBP_dimer IPR036138, PBP_dimer_sf IPR001460, PCN-bd_Tpept |
Pfami | View protein in Pfam PF03717, PBP_dimer, 1 hit PF00905, Transpeptidase, 1 hit |
SUPFAMi | SSF56519, SSF56519, 1 hit SSF56601, SSF56601, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A3M6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS
60 70 80 90 100
QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL
110 120 130 140 150
LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES
160 170 180 190 200
ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS
210 220 230 240 250
QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE
260 270 280 290 300
AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE
310 320 330 340 350
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP
360 370 380 390 400
KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG
410 420 430 440 450
VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ
460 470 480 490 500
TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST
510 520 530 540 550
GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI
560 570 580 590 600
YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT
610 620 630 640 650
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV
660 670 680
FPHNTNLTNG VGPSIARDII NLYQKYHPMN
Sequence cautioni
The sequence AAL00321 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | L → F in CAA34154 (PubMed:2798106).Curated | 1 | |
Sequence conflicti | 115 – 117 | QLA → AG in CAA34154 (PubMed:2798106).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16022 Genomic DNA Translation: CAA34154.1 AE007317 Genomic DNA Translation: AAL00321.1 Different initiation. X13137 Genomic DNA Translation: CAA31527.1 |
PIRi | D98061 S06000 |
RefSeqi | NP_359110.1, NC_003098.1 WP_001224867.1, NC_003098.1 |
Genome annotation databases
EnsemblBacteriai | AAL00321; AAL00321; spr1517 |
KEGGi | spr:spr1517 |
PATRICi | fig|171101.6.peg.1637 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16022 Genomic DNA Translation: CAA34154.1 AE007317 Genomic DNA Translation: AAL00321.1 Different initiation. X13137 Genomic DNA Translation: CAA31527.1 |
PIRi | D98061 S06000 |
RefSeqi | NP_359110.1, NC_003098.1 WP_001224867.1, NC_003098.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WAD | X-ray | 2.18 | A/B/C | 1-680 | [»] | |
2WAE | X-ray | 2.26 | A | 1-680 | [»] | |
2WAF | X-ray | 3.29 | A | 1-680 | [»] | |
SMRi | P0A3M6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 171101.spr1517 |
Chemistry databases
ChEMBLi | CHEMBL4296322 |
DrugBanki | DB01163, Amdinocillin DB00415, Ampicillin DB08795, Azidocillin DB01140, Cefadroxil DB00456, Cefalotin DB01066, Cefditoren DB00493, Cefotaxime DB01331, Cefoxitin DB01212, Ceftriaxone DB00567, Cephalexin DB03313, Cephalosporin C DB00485, Dicloxacillin DB00739, Hetacillin DB01603, Meticillin DB00607, Nafcillin DB00713, Oxacillin DB00319, Piperacillin |
Genome annotation databases
EnsemblBacteriai | AAL00321; AAL00321; spr1517 |
KEGGi | spr:spr1517 |
PATRICi | fig|171101.6.peg.1637 |
Phylogenomic databases
eggNOGi | COG0768, Bacteria |
HOGENOMi | CLU_009289_7_0_9 |
Miscellaneous databases
EvolutionaryTracei | P0A3M6 |
Family and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR005311, PBP_dimer IPR036138, PBP_dimer_sf IPR001460, PCN-bd_Tpept |
Pfami | View protein in Pfam PF03717, PBP_dimer, 1 hit PF00905, Transpeptidase, 1 hit |
SUPFAMi | SSF56519, SSF56519, 1 hit SSF56601, SSF56601, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PBP2_STRR6 | |
Accessioni | P0A3M6Primary (citable) accession number: P0A3M6 Secondary accession number(s): P10524 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families