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Protein

Pesticidal crystal protein Cry1Ab

Gene

cry1Ab

Organism
Bacillus thuringiensis subsp. kurstaki
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae.

Miscellaneous

Toxic segment of the protein is located in the N-terminus.
In strain S93 this is encoded on plasmid pUCBtS39.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxin
Biological processSporulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.2.1.3 the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pesticidal crystal protein Cry1Ab
Alternative name(s):
130 kDa crystal protein
Crystaline entomocidal protoxin
Insecticidal delta-endotoxin CryIA(b)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cry1Ab
Synonyms:bt2, cry-1-2, cry1A(b), cryIA(b), cryIC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pUCBtS931 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus thuringiensis subsp. kurstaki
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29339 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Introduced by genetic manipulation and expressed in insect-resistant maize by Monsanto, Northrup King and Ciba Geigy.

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001740231 – 1155Pesticidal crystal protein Cry1AbAdd BLAST1155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0A370

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A370

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the delta endotoxin family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.190.10, 1 hit
2.100.10.10, 1 hit
2.60.120.260, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR038979 Pest_crys
IPR005638 Pest_crys_C
IPR005639 Pest_crys_N
IPR036716 Pest_crys_N_sf
IPR001178 Pest_cryst_cen_dom
IPR036399 Pest_cryst_cen_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR37003 PTHR37003, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03944 Endotoxin_C, 1 hit
PF00555 Endotoxin_M, 1 hit
PF03945 Endotoxin_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF51096 SSF51096, 1 hit
SSF56849 SSF56849, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNNPNINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF
60 70 80 90 100
VPGAGFVLGL VDIIWGIFGP SQWDAFLVQI EQLINQRIEE FARNQAISRL
110 120 130 140 150
EGLSNLYQIY AESFREWEAD PTNPALREEM RIQFNDMNSA LTTAIPLFAV
160 170 180 190 200
QNYQVPLLSV YVQAANLHLS VLRDVSVFGQ RWGFDAATIN SRYNDLTRLI
210 220 230 240 250
GNYTDHAVRW YNTGLERVWG PDSRDWIRYN QFRRELTLTV LDIVSLFPNY
260 270 280 290 300
DSRTYPIRTV SQLTREIYTN PVLENFDGSF RGSAQGIEGS IRSPHLMDIL
310 320 330 340 350
NSITIYTDAH RGEYYWSGHQ IMASPVGFSG PEFTFPLYGT MGNAAPQQRI
360 370 380 390 400
VAQLGQGVYR TLSSTLYRRP FNIGINNQQL SVLDGTEFAY GTSSNLPSAV
410 420 430 440 450
YRKSGTVDSL DEIPPQNNNV PPRQGFSHRL SHVSMFRSGF SNSSVSIIRA
460 470 480 490 500
PMFSWIHRSA EFNNIIPSSQ ITQIPLTKST NLGSGTSVVK GPGFTGGDIL
510 520 530 540 550
RRTSPGQIST LRVNITAPLS QRYRVRIRYA STTNLQFHTS IDGRPINQGN
560 570 580 590 600
FSATMSSGSN LQSGSFRTVG FTTPFNFSNG SSVFTLSAHV FNSGNEVYID
610 620 630 640 650
RIEFVPAEVT FEAEYDLERA QKAVNELFTS SNQIGLKTDV TDYHIDQVSN
660 670 680 690 700
LVECLSDEFC LDEKKELSEK VKHAKRLSDE RNLLQDPNFR GINRQLDRGW
710 720 730 740 750
RGSTDITIQG GDDVFKENYV TLLGTFDECY PTYLYQKIDE SKLKAYTRYQ
760 770 780 790 800
LRGYIEDSQD LEIYLIRYNA KHETVNVPGT GSLWPLSAPS PIGKCAHHSH
810 820 830 840 850
HFSLDIDVGC TDLNEDLGVW VIFKIKTQDG HARLGNLEFL EEKPLVGEAL
860 870 880 890 900
ARVKRAEKKW RDKREKLEWE TNIVYKEAKE SVDALFVNSQ YDRLQADTNI
910 920 930 940 950
AMIHAADKRV HSIREAYLPE LSVIPGVNAA IFEELEGRIF TAFSLYDARN
960 970 980 990 1000
VIKNGDFNNG LSCWNVKGHV DVEEQNNHRS VLVVPEWEAE VSQEVRVCPG
1010 1020 1030 1040 1050
RGYILRVTAY KEGYGEGCVT IHEIENNTDE LKFSNCVEEE VYPNNTVTCN
1060 1070 1080 1090 1100
DYTATQEEYE GTYTSRNRGY DGAYESNSSV PADYASAYEE KAYTDGRRDN
1110 1120 1130 1140 1150
PCESNRGYGD YTPLPAGYVT KELEYFPETD KVWIEIGETE GTFIVDSVEL

LLMEE
Length:1,155
Mass (Da):130,624
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43461A64C7AC7CAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207A → R in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti382 – 406VLDGT…RKSGT → GPDGGRICLWNLLKFGQPPY TEKAEP in AAA22613 (PubMed:3011746).CuratedAdd BLAST25
Sequence conflicti410L → P in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti430 – 432LSH → CLAY in AAA22613 (PubMed:3011746).Curated3
Sequence conflicti437R → Y in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti447I → V in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti452 – 458MFSWIHR → NDSSWTYC in AAA22613 (PubMed:3011746).Curated7
Sequence conflicti461E → N in AAA22420 (Ref. 5) Curated1
Sequence conflicti463 – 465NNI → GDV in AAA22613 (PubMed:3011746).Curated3
Sequence conflicti479 – 486STNLGSGT → LQSWLWN in AAA22613 (PubMed:3011746).Curated8
Sequence conflicti492P → L in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti501 – 505RRTSP → EELT in AAA22613 (PubMed:3011746).Curated5
Sequence conflicti542D → H in AAA22420 (Ref. 5) Curated1
Sequence conflicti568 – 569TV → HL in AAA22420 (Ref. 5) Curated2
Sequence conflicti665K → E in AAA22420 (Ref. 5) Curated1
Sequence conflicti675 – 676KR → NG in AAA22420 (Ref. 5) Curated2
Sequence conflicti703S → N in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti712D → H in AAA22613 (PubMed:3011746).Curated1
Sequence conflicti832A → E no nucleotide entry (Ref. 4) Curated1
Sequence conflicti836N → I in AAA22420 (Ref. 5) Curated1
Sequence conflicti842 – 843EK → GRA no nucleotide entry (Ref. 4) Curated2
Sequence conflicti1016E → T in AAA22420 (Ref. 5) Curated1
Sequence conflicti1060E → G in AAA22420 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15271 Genomic DNA Translation: AAA22561.1
M12661 Genomic DNA Translation: AAA22613.1
D00117 Genomic DNA Translation: BAA00071.1
M37263 Genomic DNA Translation: AAA22420.1
AF059670 Genomic DNA Translation: AAC64003.1
A03793 Unassigned DNA Translation: CAA00303.1
A09398 Unassigned DNA Translation: CAA00840.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A29125
A29838
A90025 JD0002
I39838

NCBI Reference Sequences

More...
RefSeqi
WP_000369819.1, NZ_PGEH01000375.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15271 Genomic DNA Translation: AAA22561.1
M12661 Genomic DNA Translation: AAA22613.1
D00117 Genomic DNA Translation: BAA00071.1
M37263 Genomic DNA Translation: AAA22420.1
AF059670 Genomic DNA Translation: AAC64003.1
A03793 Unassigned DNA Translation: CAA00303.1
A09398 Unassigned DNA Translation: CAA00840.1
PIRiA29125
A29838
A90025 JD0002
I39838
RefSeqiWP_000369819.1, NZ_PGEH01000375.1

3D structure databases

ProteinModelPortaliP0A370
SMRiP0A370
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.2.1.3 the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.190.10, 1 hit
2.100.10.10, 1 hit
2.60.120.260, 2 hits
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR038979 Pest_crys
IPR005638 Pest_crys_C
IPR005639 Pest_crys_N
IPR036716 Pest_crys_N_sf
IPR001178 Pest_cryst_cen_dom
IPR036399 Pest_cryst_cen_dom_sf
PANTHERiPTHR37003 PTHR37003, 1 hit
PfamiView protein in Pfam
PF03944 Endotoxin_C, 1 hit
PF00555 Endotoxin_M, 1 hit
PF03945 Endotoxin_N, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51096 SSF51096, 1 hit
SSF56849 SSF56849, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCR1AB_BACTK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A370
Secondary accession number(s): P06577
, P06578, P09663, P09666, P09667, P21257, Q45789
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 18, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Genetically modified food, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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