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UniProtKB - P0A367 (CR1AA_BACTA)
Protein
Pesticidal crystal protein Cry1Aa
Gene
cry1Aa
Organism
Bacillus thuringiensis subsp. aizawai
Status
Functioni
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae.
Miscellaneous
Toxic segment of the protein is located in the N-terminus.
GO - Molecular functioni
- signaling receptor binding Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- cytolysis by symbiont of host cells Source: InterPro
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Keywordsi
Molecular function | Toxin |
Biological process | Sporulation, Virulence |
Protein family/group databases
TCDBi | 1.C.2.1.1, the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Pesticidal crystal protein Cry1AaAlternative name(s): 133 kDa crystal protein Crystaline entomocidal protoxin Insecticidal delta-endotoxin CryIA(a) |
Gene namesi | Name:cry1Aa Synonyms:cry-1-1, cry1A(a), cryA, crybns3-1, cryIA(a), icp |
Organismi | Bacillus thuringiensis subsp. aizawai |
Taxonomic identifieri | 1433 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174017 | 1 – 1176 | Pesticidal crystal protein Cry1AaAdd BLAST | 1176 |
Expressioni
Developmental stagei
The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat.
Family & Domainsi
Sequence similaritiesi
Belongs to the delta endotoxin family.Curated
Family and domain databases
Gene3Di | 1.20.190.10, 1 hit 2.100.10.10, 1 hit |
InterProi | View protein in InterPro IPR041587, Cry_V IPR008979, Galactose-bd-like_sf IPR038979, Pest_crys IPR005638, Pest_crys_C IPR005639, Pest_crys_N IPR036716, Pest_crys_N_sf IPR001178, Pest_cryst_cen_dom IPR036399, Pest_cryst_cen_dom_sf |
PANTHERi | PTHR37003, PTHR37003, 1 hit |
Pfami | View protein in Pfam PF17997, Cry1Ac_D5, 1 hit PF03944, Endotoxin_C, 1 hit PF00555, Endotoxin_M, 1 hit PF03945, Endotoxin_N, 1 hit |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF51096, SSF51096, 1 hit SSF56849, SSF56849, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A367-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNNPNINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF
60 70 80 90 100
VPGAGFVLGL VDIIWGIFGP SQWDAFLVQI EQLINQRIEE FARNQAISRL
110 120 130 140 150
EGLSNLYQIY AESFREWEAD PTNPALREEM RIQFNDMNSA LTTAIPLFAV
160 170 180 190 200
QNYQVPLLSV YVQAANLHLS VLRDVSVFGQ RWGFDAATIN SRYNDLTRLI
210 220 230 240 250
GNYTDYAVRW YNTGLERVWG PDSRDWVRYN QFRRELTLTV LDIVALFSNY
260 270 280 290 300
DSRRYPIRTV SQLTREIYTN PVLENFDGSF RGMAQRIEQN IRQPHLMDIL
310 320 330 340 350
NSITIYTDVH RGFNYWSGHQ ITASPVGFSG PEFAFPLFGN AGNAAPPVLV
360 370 380 390 400
SLTGLGIFRT LSSPLYRRII LGSGPNNQEL FVLDGTEFSF ASLTTNLPST
410 420 430 440 450
IYRQRGTVDS LDVIPPQDNS VPPRAGFSHR LSHVTMLSQA AGAVYTLRAP
460 470 480 490 500
TFSWQHRSAE FNNIIPSSQI TQIPLTKSTN LGSGTSVVKG PGFTGGDILR
510 520 530 540 550
RTSPGQISTL RVNITAPLSQ RYRVRIRYAS TTNLQFHTSI DGRPINQGNF
560 570 580 590 600
SATMSSGSNL QSGSFRTVGF TTPFNFSNGS SVFTLSAHVF NSGNEVYIDR
610 620 630 640 650
IEFVPAEVTF EAEYDLERAQ KAVNELFTSS NQIGLKTDVT DYHIDQVSNL
660 670 680 690 700
VECLSDEFCL DEKQELSEKV KHAKRLSDER NLLQDPNFRG INRQLDRGWR
710 720 730 740 750
GSTDITIQGG DDVFKENYVT LLGTFDECYP TYLYQKIDES KLKAYTRYQL
760 770 780 790 800
RGYIEDSQDL EIYLIRYNAK HETVNVPGTG SLWPLSAQSP IGKCGEPNRC
810 820 830 840 850
APHLEWNPDL DCSCRDGEKC AHHSHHFSLD IDVGCTDLNE DLGVWVIFKI
860 870 880 890 900
KTQDGHARLG NLEFLEEKPL VGEALARVKR AEKKWRDKRE KLEWETNIVY
910 920 930 940 950
KEAKESVDAL FVNSQYDQLQ ADTNIAMIHA ADKRVHSIRE AYLPELSVIP
960 970 980 990 1000
GVNAAIFEEL EGRIFTAFSL YDARNVIKNG DFNNGLSCWN VKGHVDVEEQ
1010 1020 1030 1040 1050
NNQRSVLVVP EWEAEVSQEV RVCPGRGYIL RVTAYKEGYG EGCVTIHEIE
1060 1070 1080 1090 1100
NNTDELKFSN CVEEEIYPNN TVTCNDYTVN QEEYGGAYTS RNRGYNEAPS
1110 1120 1130 1140 1150
VPADYASVYE EKSYTDGRRE NPCEFNRGYR DYTPLPVGYV TKELEYFPET
1160 1170
DKVWIEIGET EGTFIVDSVE LLLMEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00348 Genomic DNA Translation: BAA00257.1 |
PIRi | JT0241 |
RefSeqi | WP_000369823.1, NZ_NFEU01000196.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00348 Genomic DNA Translation: BAA00257.1 |
PIRi | JT0241 |
RefSeqi | WP_000369823.1, NZ_NFEU01000196.1 |
3D structure databases
SMRi | P0A367 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 1.C.2.1.1, the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family |
Family and domain databases
Gene3Di | 1.20.190.10, 1 hit 2.100.10.10, 1 hit |
InterProi | View protein in InterPro IPR041587, Cry_V IPR008979, Galactose-bd-like_sf IPR038979, Pest_crys IPR005638, Pest_crys_C IPR005639, Pest_crys_N IPR036716, Pest_crys_N_sf IPR001178, Pest_cryst_cen_dom IPR036399, Pest_cryst_cen_dom_sf |
PANTHERi | PTHR37003, PTHR37003, 1 hit |
Pfami | View protein in Pfam PF17997, Cry1Ac_D5, 1 hit PF03944, Endotoxin_C, 1 hit PF00555, Endotoxin_M, 1 hit PF03945, Endotoxin_N, 1 hit |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF51096, SSF51096, 1 hit SSF56849, SSF56849, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CR1AA_BACTA | |
Accessioni | P0A367Primary (citable) accession number: P0A367 Secondary accession number(s): P02965 Q9RED5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | March 15, 2005 | |
Last modified: | September 29, 2021 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |