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Protein

Mercuric resistance operon regulatory protein

Gene

merR

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Mercury1
Metal bindingi117Mercury1
Metal bindingi126Mercury1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi10 – 29H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processMercuric resistance, Transcription, Transcription regulation
LigandMercury, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mercuric resistance operon regulatory protein
Gene namesi
Name:merR
Encoded oniPlasmid IncFII R100 (NR1)0 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981411 – 144Mercuric resistance operon regulatory proteinAdd BLAST144

Structurei

3D structure databases

ProteinModelPortaliP0A2Q9
SMRiP0A2Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 76HTH merR-typePROSITE-ProRule annotationAdd BLAST70

Family and domain databases

CDDicd04783 HTH_MerR1, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR011794 MerR
IPR000551 MerR-type_HTH_dom
IPR015358 Tscrpt_reg_MerR_DNA-bd
PfamiView protein in Pfam
PF00376 MerR, 1 hit
PF09278 MerR-DNA-bind, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02051 MerR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A2Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENNLENLTI GVFAKAAGVN VETIRFYQRK GLLREPDKPY GSIRRYGEAD
60 70 80 90 100
VVRVKFVKSA QRLGFSLDEI AELLRLDDGT HCEEASSLAE HKLKDVREKM
110 120 130 140
ADLARMETVL SELVCACHAR KGNVSCPLIA SLQGEAGLAR SAMP
Length:144
Mass (Da):15,905
Last modified:April 1, 1988 - v1
Checksum:i8BEEC928A7B83EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03089 Genomic DNA Translation: AAB59072.1
RefSeqiWP_000429836.1, NZ_NIYQ01000008.1

Genome annotation databases

GeneIDi4999093

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03089 Genomic DNA Translation: AAB59072.1
RefSeqiWP_000429836.1, NZ_NIYQ01000008.1

3D structure databases

ProteinModelPortaliP0A2Q9
SMRiP0A2Q9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4999093

Family and domain databases

CDDicd04783 HTH_MerR1, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR011794 MerR
IPR000551 MerR-type_HTH_dom
IPR015358 Tscrpt_reg_MerR_DNA-bd
PfamiView protein in Pfam
PF00376 MerR, 1 hit
PF09278 MerR-DNA-bind, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02051 MerR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMERR_SHIFL
AccessioniPrimary (citable) accession number: P0A2Q9
Secondary accession number(s): P07044
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid, Transposable element
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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