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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity).UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Acyl-thioester intermediateUniRule annotation1
Active sitei343Proton acceptorUniRule annotation1
Active sitei373Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-4021-MONOMER
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:STM3982
ORF Names:STMD1.7
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063911 – 3873-ketoacyl-CoA thiolaseAdd BLAST387

Proteomic databases

PaxDbiP0A2H7
PRIDEiP0A2H7

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3982

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Turni17 – 19Combined sources3
Turni21 – 24Combined sources4
Helixi27 – 41Combined sources15
Helixi47 – 49Combined sources3
Beta strandi52 – 56Combined sources5
Turni63 – 67Combined sources5
Helixi68 – 75Combined sources8
Beta strandi85 – 88Combined sources4
Helixi90 – 92Combined sources3
Helixi93 – 106Combined sources14
Beta strandi111 – 119Combined sources9
Turni121 – 123Combined sources3
Turni126 – 129Combined sources4
Helixi148 – 157Combined sources10
Helixi162 – 182Combined sources21
Turni183 – 188Combined sources6
Beta strandi192 – 195Combined sources4
Beta strandi201 – 204Combined sources4
Helixi216 – 219Combined sources4
Turni228 – 230Combined sources3
Helixi235 – 237Combined sources3
Beta strandi242 – 252Combined sources11
Helixi253 – 258Combined sources6
Beta strandi265 – 274Combined sources10
Helixi284 – 295Combined sources12
Helixi299 – 301Combined sources3
Beta strandi303 – 307Combined sources5
Helixi312 – 321Combined sources10
Helixi325 – 327Combined sources3
Helixi328 – 331Combined sources4
Helixi338 – 341Combined sources4
Helixi345 – 362Combined sources18
Beta strandi366 – 374Combined sources9
Turni375 – 377Combined sources3
Beta strandi378 – 385Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GOAX-ray1.70A/B1-387[»]
ProteinModelPortaliP0A2H7
SMRiP0A2H7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A2H7

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012239
KOiK00632
OMAiCGGTESM
PhylomeDBiP0A2H7

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
HAMAPiMF_01620 FadA, 1 hit
InterProiView protein in InterPro
IPR012805 FadA
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02445 fadA, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P0A2H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVVIVDAI RTPMGRSKGG AFRNVRAEDL SAHLMRSLLA RNPSLTAATL
60 70 80 90 100
DDIYWGCVQQ TLEQGFNIAR NAALLAEIPH SVPAVTVNRL CGSSMQALHD
110 120 130 140 150
AARMIMTGDA QVCLVGGVEH MGHVPMSHGV DFHPGLSRNV AKAAGMMGLT
160 170 180 190 200
AEMLSRLHGI SREMQDQFAA RSHARAWAAT QSGAFKTEII PTGGHDADGV
210 220 230 240 250
LKQFNYDEVI RPETTVEALS TLRPAFDPVS GTVTAGTSSA LSDGAAAMLV
260 270 280 290 300
MSESRARELG LKPRARIRSM AVVGCDPSIM GYGPVPASKL ALKKAGLSAS
310 320 330 340 350
DIDVFEMNEA FAAQILPCIK DLGLMEQIDE KINLNGGAIA LGHPLGCSGA
360 370 380
RISTTLINLM ERKDAQFGLA TMCIGLGQGI ATVFERV
Length:387
Mass (Da):41,004
Last modified:March 15, 2005 - v1
Checksum:i39E24805360ABD8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233324 Genomic DNA Translation: AAF33416.1
AE006468 Genomic DNA Translation: AAL22826.1
RefSeqiNP_462867.1, NC_003197.2
WP_000438778.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22826; AAL22826; STM3982
GeneIDi1255508
KEGGistm:STM3982
PATRICifig|99287.12.peg.4201

Similar proteinsi

Entry informationi

Entry nameiFADA_SALTY
AccessioniPrimary (citable) accession number: P0A2H7
Secondary accession number(s): Q9L6L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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