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Protein

Uridine phosphorylase

Gene

udp

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase (udp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-4007-MONOMER
BRENDAi2.4.2.3 5542
UniPathwayi
UPA00574;UER00633

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase (EC:2.4.2.3)
Short name:
UPase
Short name:
UrdPase
Gene namesi
Name:udp
Ordered Locus Names:STM3968
ORF Names:STMD1.21
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB04627 Cyclouridine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000631852 – 253Uridine phosphorylaseAdd BLAST252

Proteomic databases

PaxDbiP0A1F6
PRIDEiP0A1F6

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3968

Structurei

Secondary structure

1253
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A1F6
SMRiP0A1F6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A1F6

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiENOG4107SXA Bacteria
COG2820 LUCA
HOGENOMiHOG000274897
KOiK00757
OMAiMSDVFHL
PhylomeDBiP0A1F6

Family and domain databases

InterProiView protein in InterPro
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR010058 Uridine_phosphorylase
PANTHERiPTHR43691:SF7 PTHR43691:SF7, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01718 Uridine-psphlse, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSDVFHLG LTKNDLQGAQ LAIVPGDPER VEKIAALMDK PVKLASHREF
60 70 80 90 100
TSWRAELDGK AVIVCSTGIG GPSTSIAVEE LAQLGIRTFL RIGTTGAIQP
110 120 130 140 150
HINVGDVLVT TASVRLDGAS LHFAPMEFPA VADFACTTAL VEAAKSIGAT
160 170 180 190 200
THVGVTASSD TFYPGQERYD TYSGRVVRRF KGSMEEWQAM GVMNYEMESA
210 220 230 240 250
TLLTMCASQG LRAGMVAGVI VNRTQQEIPN AETMKQTESH AVKIVVEAAR

RLL
Length:253
Mass (Da):27,139
Last modified:January 23, 2007 - v2
Checksum:i63F26AFB8427BED2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200A → R in CAA73795 (PubMed:9661793).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14282 Genomic DNA Translation: CAA74658.2
Y13360 Genomic DNA Translation: CAA73795.1
AF233324 Genomic DNA Translation: AAF33424.1
AE006468 Genomic DNA Translation: AAL22812.1
RefSeqiNP_462853.1, NC_003197.2
WP_000045169.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22812; AAL22812; STM3968
GeneIDi1255494
KEGGistm:STM3968
PATRICifig|99287.12.peg.4187

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14282 Genomic DNA Translation: CAA74658.2
Y13360 Genomic DNA Translation: CAA73795.1
AF233324 Genomic DNA Translation: AAF33424.1
AE006468 Genomic DNA Translation: AAL22812.1
RefSeqiNP_462853.1, NC_003197.2
WP_000045169.1, NC_003197.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RYZX-ray2.90A/B/C/D/E/F1-253[»]
1SJ9X-ray2.50A/B/C/D/E/F1-253[»]
1Y1QX-ray2.35A/B/C/D/E/F1-253[»]
1Y1RX-ray2.11A/B/C/D/E/F1-253[»]
1Y1SX-ray2.55A/B/C/D/E/F1-253[»]
1Y1TX-ray1.77A/F1-253[»]
1ZL2X-ray1.85A/B/C/D/E/F1-253[»]
2HN9X-ray2.12A/B/C/D/E/F1-253[»]
2HRDX-ray1.70A/B/C/D/E/F1-253[»]
2HSWX-ray1.99A/B1-253[»]
2HWUX-ray2.91A/B/C/D/E/F1-253[»]
2I8AX-ray1.64A/B/C/D/E/F2-253[»]
2IQ5X-ray1.90A/B2-253[»]
2OECX-ray2.19A/B/C/D/E/F2-253[»]
2OXFX-ray1.76A/F4-253[»]
2PGAX-ray1.74A/B/C/D/E/F1-253[»]
2QDKX-ray1.62A/B/C/D/E/F2-253[»]
2RJ3X-ray2.51A/B/C/D/E/F2-253[»]
3C74X-ray2.38A/B/C/D/E/F2-253[»]
3DDOX-ray1.50A/B/C/D/E/F1-253[»]
3DPSX-ray1.80A/F1-253[»]
3FWPX-ray1.86A/B/C/D/E/F1-253[»]
4E1VX-ray2.15A/B/C/D/E/F/G/H/I1-253[»]
4OGKX-ray2.40A/B/C/D/E/F1-253[»]
ProteinModelPortaliP0A1F6
SMRiP0A1F6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3968

Chemistry databases

DrugBankiDB04627 Cyclouridine

Proteomic databases

PaxDbiP0A1F6
PRIDEiP0A1F6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22812; AAL22812; STM3968
GeneIDi1255494
KEGGistm:STM3968
PATRICifig|99287.12.peg.4187

Phylogenomic databases

eggNOGiENOG4107SXA Bacteria
COG2820 LUCA
HOGENOMiHOG000274897
KOiK00757
OMAiMSDVFHL
PhylomeDBiP0A1F6

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00633

BioCyciSENT99287:G1FZD-4007-MONOMER
BRENDAi2.4.2.3 5542

Miscellaneous databases

EvolutionaryTraceiP0A1F6

Family and domain databases

InterProiView protein in InterPro
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR010058 Uridine_phosphorylase
PANTHERiPTHR43691:SF7 PTHR43691:SF7, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01718 Uridine-psphlse, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUDP_SALTY
AccessioniPrimary (citable) accession number: P0A1F6
Secondary accession number(s): O08432, O33808, Q9L6M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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